Toxicity of indium arsenide, gallium arsenide, and aluminium gallium arsenide.


:Gallium arsenide (GaAs), indium arsenide (InAs), and aluminium gallium arsenide (AlGaAs) are semiconductor applications. Although the increased use of these materials has raised concerns about occupational exposure to them, there is little information regarding the adverse health effects to workers arising from exposure to these particles. However, available data indicate these semiconductor materials can be toxic in animals. Although acute and chronic toxicity of the lung, reproductive organs, and kidney are associated with exposure to these semiconductor materials, in particular, chronic toxicity should pay much attention owing to low solubility of these materials. Between InAs, GaAs, and AlGaAs, InAs was the most toxic material to the lung followed by GaAs and AlGaAs when given intratracheally. This was probably due to difference in the toxicity of the counter-element of arsenic in semiconductor materials, such as indium, gallium, or aluminium, and not arsenic itself. It appeared that indium, gallium, or aluminium was toxic when released from the particles, though the physical character of the particles also contributes to toxic effect. Although there is no evidence of the carcinogenicity of InAs or AlGaAs, GaAs and InP, which are semiconductor materials, showed the clear evidence of carcinogenic potential. It is necessary to pay much greater attention to the human exposure of semiconductor materials.


Toxicol Appl Pharmacol


Tanaka A




Has Abstract


2004-08-01 00:00:00














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    abstract::Nonmelanoma skin cancer is the most common cancer among humans and solar UV radiation, particularly its UVB component (290-320 nm), is its major cause. One way to reduce the occurrence of the cancer is via the use of substances (often antioxidants) termed "photochemopreventive agents". Resveratrol (trans-3,4',5-trihyd...

    journal_title:Toxicology and applied pharmacology

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    authors: Afaq F,Adhami VM,Ahmad N

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    authors: Ishii Y,Kuroda K,Matsushita K,Yokoo Y,Takasu S,Kijima A,Nohmi T,Ogawa K,Umemura T

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    abstract::Four triazole fungicides used in agricultural or pharmaceutical applications were examined for hepatotoxic effects in mouse liver. Besides organ weight, histopathology, and cytochrome P450 (CYP) enzyme induction, DNA microarrays were used to generate gene expression profiles and hypotheses on potential mechanisms of a...

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    authors: Goetz AK,Bao W,Ren H,Schmid JE,Tully DB,Wood C,Rockett JC,Narotsky MG,Sun G,Lambert GR,Thai SF,Wolf DC,Nesnow S,Dix DJ

    更新日期:2006-09-15 00:00:00

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    authors: Hartmann CB,McCoy KL

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    journal_title:Toxicology and applied pharmacology

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    authors: Peterson RL,Casciotti L,Block L,Goad ME,Tong Z,Meehan JT,Jordan RA,Vinlove MP,Markiewicz VR,Weed CA,Dorner AJ

    更新日期:2004-04-01 00:00:00

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    authors: Ranganathan S,Churchill PF,Hood RD

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    authors: Wei KL,Chen FY,Lin CY,Gao GL,Kao WY,Yeh CH,Chen CR,Huang HC,Tsai WR,Jong KJ,Li WJ,Su JG

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    authors: Giglio MJ,Brandan N,Leal TL,Bozzini CE

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  • Comparison of the effects of redox cycling and arylating quinones on hepatobiliary function and glutathione homeostasis in rat hepatocyte couplets.

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    authors: Stone V,Coleman R,Chipman JK

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    journal_title:Toxicology and applied pharmacology

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    authors: Sterling K,Raha A,Bresnick E

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    authors: Dykens JA,Jamieson J,Marroquin L,Nadanaciva S,Billis PA,Will Y

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    journal_title:Toxicology and applied pharmacology

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    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


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    authors: Viquez OM,Valentine HL,Amarnath K,Milatovic D,Valentine WM

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