JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats.

abstract：:Hepatic expression of the proinflammatory cytokine tumor necrosis factor-alpha (TNFalpha) occurs in many acute and chronic liver diseases, as well as following exposure to hepatotoxic chemicals, and is believed to help influence both the damage and repair processes that occur following these insults by regulating addi...

journal_title：Toxicology and applied pharmacology

authors： Simeonova PP,Gallucci RM,Hulderman T,Wilson R,Kommineni C,Rao M,Luster MI

更新日期：2001-12-01 00:00:00

abstract：:There is concern that P-glycoprotein mediated efflux contributes to steroid resistance. Therefore, this study examined bidirectional corticosteroid transport and induction capabilities for P-glycoprotein (P-gp) to understand which of the systemic and inhaled corticosteroids interacted with P-gp to the greatest extent....

journal_title：Toxicology and applied pharmacology

authors： Crowe A,Tan AM

更新日期：2012-05-01 00:00:00

abstract：:An accumulation of hydrophobic bile acids is implicated in the pathogenesis of cholestatic liver diseases. In the present study, we determined if hydrophobic bile acid-induced cellular injury compromised hepatocyte glutathione (GSH) status, and if modulating intracellular GSH levels prevented or facilitated bile acid-...

journal_title：Toxicology and applied pharmacology

authors： Gumpricht E,Devereaux MW,Dahl RH,Sokol RJ

更新日期：2000-04-01 00:00:00

abstract：:1p4studied the effect of L-2-chloropropionic acid (L-CPA)-induced (250 mg/kg/po/day for 3 days) neurotoxicity, which results in an almost total destruction of cerebellar granule cells over 5 days, on forebrain and cerebellar neurochemistry. There was a reduction in cerebellar aspartate and glutamate concentrations of ...

journal_title：Toxicology and applied pharmacology

authors： Widdowson PS,Gyte A,Simpson MG,Wyatt I,Lock EA

更新日期：1996-01-01 00:00:00

abstract：:Glyphosate (GLY) usage for weed control is extensive. To investigate ovarian impacts of chronic GLY exposure, female C57BL6 mice were orally administered saline as vehicle control (CT) or GLY at 0.25 (G0.25), 0.5 (G0.5), 1.0 (G1.0), 1.5 (G1.5), or 2 (G2.0) mg/kg for five days per wk. for 20 wks. Feed intake increased ...

journal_title：Toxicology and applied pharmacology

authors： Ganesan S,Keating AF

更新日期：2020-09-01 00:00:00

abstract：:Dopamine (DA), a monoamine catecholamine neurotransmitter with antiangiogenic activity, stabilizes tumor vessels in colon, prostate and ovarian cancers, thus increases chemotherapeutic efficacy. Here, in the rat C6 glioma models, we investigated the vascular normalization effects of DA and its mechanisms of action. DA...

journal_title：Toxicology and applied pharmacology

authors： Qin T,Wang C,Chen X,Duan C,Zhang X,Zhang J,Chai H,Tang T,Chen H,Yue J,Li Y,Yang J

更新日期：2015-07-15 00:00:00

abstract：:In nonsmokers, ozone (O(3)) is removed primarily by the epithelial lining fluid (ELF) of the conducting airways. We hypothesized that cigarette smokers, whose ELF antioxidant capacity may be limited by smoking, would remove less O(3) from their conducting airways than nonsmokers. We recruited 29 nonsmokers (17M, 12F) ...

journal_title：Toxicology and applied pharmacology

authors： Bates ML,Brenza TM,Ben-Jebria A,Bascom R,Ultman JS

更新日期：2009-05-01 00:00:00

abstract：:Various drugs have been shown to stimulate surfactant phospholipid metabolism. Particularly beta-adrenergic agonists play an important role under physiologic conditions. For the first time we have studied whether nitrogen dioxide (NO2) inhalation alters beta-adrenergic regulation of surfactant phospholipid metabolism ...

journal_title：Toxicology and applied pharmacology

authors： Mengel RG,Bernhard W,Barth P,von Wichert P,Müller B

更新日期：1993-06-01 00:00:00

abstract：:Inorganic arsenicals are clearly toxicants and carcinogens in humans. In mammals, including humans, inorganic arsenic often undergoes methylation, forming compounds such as monomethylarsonic acid (MMAs(V)) and dimethylarsinic acid (DMAs(V)). However, much less information is available on the in vitro toxic potential o...

journal_title：Toxicology and applied pharmacology

authors： Sakurai T,Kojima C,Ochiai M,Ohta T,Sakurai MH,Waalkes MP,Fujiwara K

更新日期：2004-03-01 00:00:00

abstract：:Diethyl maleate (DEM) pretreatment has previously been shown to result in a transient depletion of lung glutathione and an associated decrease of the time to the onset of rat mortality resulting from exposures to 100% oxygen in vivo. The effects of oxygen exposure on mitochondrial energy metabolism were assessed by me...

journal_title：Toxicology and applied pharmacology

authors： Bassett DJ,Reichenbaugh SS

更新日期：1992-08-01 00:00:00

abstract：:Hydrolytic metabolism of pyrethroid insecticides in humans is one of the major catabolic pathways that clear these compounds from the body. Rodent models are often used to determine the disposition and clearance rates of these esterified compounds. In this study the distribution and activities of esterases that cataly...

journal_title：Toxicology and applied pharmacology

authors： Crow JA,Borazjani A,Potter PM,Ross MK

更新日期：2007-05-15 00:00:00

abstract：:Acetaminophen (APAP) nephrotoxicity has been observed both in humans and research animals. Recent studies suggest a contributory role for glutathione (GSH)-derived conjugates of APAP in the development of nephrotoxicity. Inhibitors of either gamma-glutamyl transpeptidase (gamma-GT) or the probenecid-sensitive organic ...

journal_title：Toxicology and applied pharmacology

authors： Stern ST,Bruno MK,Hennig GE,Horton RA,Roberts JC,Cohen SD

更新日期：2005-01-15 00:00:00

abstract：:1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin is a chemical inducer of Parkinson's disease (PD) whereas N-methylated beta-carbolines and isoquinolines are naturally occurring analogues of MPTP involved in PD. This research has studied the oxidation of MPTP by human CYP2D6 (CYP2D6*1 and CYP2D6*10 allel...

journal_title：Toxicology and applied pharmacology

authors： Herraiz T,Guillén H,Arán VJ,Idle JR,Gonzalez FJ

更新日期：2006-11-01 00:00:00

abstract：:Neuropathy target esterase (NTE) is a membrane-bound protein with high esterase catalytic activity. The physiological function of the protein is not known and the catalytic activity is not essential to health of nerve axons. Nevertheless there is overwhelming evidence that modification of the structure of NTE by coval...

journal_title：Toxicology and applied pharmacology

authors： Johnson MK

更新日期：1990-03-01 00:00:00

abstract：:Inorganic arsenic (iAs) is a known toxicant and carcinogen. Worldwide arsenic exposure has become a threat to human health. The severity of arsenic toxicity is strongly correlated with the speed of arsenic metabolism (methylation) and clearance. Furthermore, oxidative stress is recognized as a major mechanism for arse...

journal_title：Toxicology and applied pharmacology

authors： Wang H,Zhu J,Li L,Li Y,Lv H,Xu Y,Sun G,Pi J

更新日期：2017-12-15 00:00:00

abstract：:The restoration of plasma acetylcholinesterase activity in mice following inhibition by organophosphorus pesticides and nerve agents has been attributed to synthesis of new enzyme. It is generally assumed that activity levels return to normal, are stable and do not exceed the normal level. We have observed over the pa...

journal_title：Toxicology and applied pharmacology

authors： Duysen EG,Lockridge O

更新日期：2011-09-01 00:00:00

abstract：:Human exposure to bisphenol A is controversially discussed. This review critically assesses methods for biomonitoring of bisphenol A exposures and reported concentrations of bisphenol A in blood and urine of non-occupationally ("environmentally") exposed humans. From the many methods published to assess bisphenol A co...

journal_title：Toxicology and applied pharmacology

authors： Dekant W,Völkel W

更新日期：2008-04-01 00:00:00

abstract：:Although the mechanisms responsible for chemically induced oxidative stress are under intense investigation, little is known about the effects of prooxidant chemicals on the expression of drug-metabolizing enzymes. We examined the effects of diquat (0.1 mmol/kg, ip) and ciprofibrate (0.025% w/w, diet), chemicals which...

journal_title：Toxicology and applied pharmacology

authors： Gallagher EP,Buetler TM,Stapleton PL,Wang C,Stahl DL,Eaton DL

更新日期：1995-09-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (SCC) is responsible for approximately one-sixth of all cancer-related mortality worldwide. This malignancy has a multifactorial etiology involving several environmental, dietary and genetic factors. Since esophageal cancer has often metastasized at the time of diagnosis, current tre...

journal_title：Toxicology and applied pharmacology

authors： Stoner GD,Wang LS,Chen T

更新日期：2007-11-01 00:00:00

abstract：:Cigarette smoking, arsenic and occupational exposures are well-known risk factors for the development of urothelial carcinoma (UC). Therefore, the aim of this study is to investigate whether the effect of cigarette smoking, alcohol consumption, arsenic and occupational exposures on risk of UC could be modified by gene...

journal_title：Toxicology and applied pharmacology

authors： Wang YH,Yeh SD,Shen KH,Shen CH,Juang GD,Hsu LI,Chiou HY,Chen CJ

更新日期：2009-11-15 00:00:00

abstract：:The biochemical and biological behavior of methylmercury (MeHg) was investigated by measurement of MeHg release rate from erythrocytes (RBC) of selected animal strains and species, by measurement of the intracellular distribution of MeHg in RBC, and by measurement of the binding affinity of hemoglobin (Hb) for MeHg. M...

journal_title：Toxicology and applied pharmacology

authors： Doi R,Tagawa M

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:The current COVID-19 pandemic is caused by SARS-CoV-2 which belongs to coronaviridae family. Despite the global prevalence, there are currently no vaccines or drugs. Dietary plant derived exosome-like vesicles are known as edible nanoparticles (ENPs). ENPs are filled with microRNAs (miRNAs), in bioavailable ...

journal_title：Toxicology and applied pharmacology

authors： Kalarikkal SP,Sundaram GM

更新日期：2021-01-28 00:00:00

abstract：OBJECTIVE:To provide insights into the mode of action for Ni3S2 lung carcinogenicity by examining gene expression changes in target cells after inhalation exposure. METHODS:Gene expression changes were determined in micro-dissected lung broncho-alveolar cells from Fischer 344 rats following inhalation of Ni3S2 at 0.0,...

journal_title：Toxicology and applied pharmacology

authors： Efremenko AY,Campbell JL Jr,Dodd DE,Oller AR,Clewell HJ 3rd

更新日期：2014-09-15 00:00:00

abstract：:It has been suggested that airway irritation, by acting as an adjuvant, as well as producing damage, may be an important factor related to asthma. The present study examined the window of time following acute upper and lower airway irritant exposure to determine the period of increased risk of immunological sensitizat...

journal_title：Toxicology and applied pharmacology

authors： Siegel PD,Al-Humadi NH,Nelson ER,Lewis DM,Hubbs AF

更新日期：1997-06-01 00:00:00

abstract：:Calcium uptake in cells occurs through specific membrane channels. Since cadmium and mercury inhibit calcium uptake, this study examined whether the calcium channels may also be involved in the uptake of these metals. Primary cultures of rat hepatocytes were incubated with 3 microM CdCl2 or HgCl2 in the absence or pre...

journal_title：Toxicology and applied pharmacology

authors： Blazka ME,Shaikh ZA

更新日期：1991-09-01 00:00:00

abstract：:Trimethyltin (TMT) is a neurotoxicant known to alter auditory function. The present study was designed to compare TMT-induced auditory dysfunction using behavioral, electrophysiological, and anatomical techniques. Adult male Long-Evans hooded rats (n = 9-12/group) were acutely exposed to saline, 3, 5, or 7 mg/kg TMT. ...

journal_title：Toxicology and applied pharmacology

authors： Crofton KM,Dean KF,Ménache MG,Janssen R

更新日期：1990-08-01 00:00:00

abstract：:One proposed mechanism for the development of silica-induced fibrosis is prolonged pulmonary inflammation and lung damage resulting from the secretion of reactive mediators from alveolar macrophages. Metalloporphyrins have antioxidative and antiinflammatory activities. However, the molecular basis for the antiinflamma...

journal_title：Toxicology and applied pharmacology

authors： Kang JL,Pack IS,Hong SM,Lee HS,Hah JS,Nam W,Leonard S,Castranova V

更新日期：2001-04-15 00:00:00

abstract：:The farnesoid X receptor (FXR) is a bile acid-activated transcription factor belonging to the nuclear receptor superfamily. FXR deficiency in mice results in cholestasis, metabolic disorders, and tumorigenesis in liver and intestine. FXR is known to contribute to pathogenesis by regulating gene transcription; however,...

journal_title：Toxicology and applied pharmacology

authors： Zhu Y,Li G,Dong Y,Zhou HH,Kong B,Aleksunes LM,Richardson JR,Li F,Guo GL

更新日期：2013-01-15 00:00:00

abstract：:A major obstacle in defining the mechanism of chemical-induced toxicity has been the inability to distinguish between events that cause cell death and those that result from cell death. This problem results from measuring biochemical parameters in tissues or cell pellets containing both viable and nonviable cells. In ...

journal_title：Toxicology and applied pharmacology

authors： Fariss MW,Brown MK,Schmitz JA,Reed DJ

更新日期：1985-06-30 00:00:00

abstract：:The effects of the cytochrome P450 inducer beta-naphthoflavone (BNF) on NO2 toxicity were studied in two strains of mice. In one strain (C57B1/6J), cytochrome P450 could be induced by the aromatic hydrocarbon, while in the other strain (DBA/2J) cytochrome P450 was not inducible by this compound. Mice were treated with...

journal_title：Toxicology and applied pharmacology

authors： Azoulay-Dupuis E,Mansour H,Moreau J,Lachia L

更新日期：1988-04-01 00:00:00