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Enzyme mediated superoxide radical formation initiated by exogenous molecules in rat brain preparations.

Abstract：

:The ability of brain tissue preparation to generate superoxide from xenobiotic interactions has been investigated. We showed that a significant superoxide production occurred with different molecules known to undergo a single electron reductive pathway of metabolism, both in a homogenate derived from neuronal and glial cells and in isolated cerebral microvessels which form the blood-brain barrier. Determination of the nucleotide cofactors requirement and data obtained with different subcellular fractions indicated that this production was largely associated with the microsomal fraction in a NADPH-dependent pathway and was probably mediated by NADPH-cytochrome P450 (c) reductase. A significant xenobiotic-mediated production of superoxide also occurred in mitochondria under in vitro conditions. Thus the evidence of reductive pathways of xenobiotic metabolism and the generation of oxygenated free radicals observed are of neurotoxicological significance.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Ghersi-Egea JF,Livertoux MH,Minn A,Perrin R,Siest G

doi

10.1016/0041-008x(91)90294-o

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

107-17

issue

1

eissn

0041-008X

issn

1096-0333

journal_volume

110

pub_type

杂志文章

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