Toluene exposure increases aminophylline-induced seizure susceptibility in mice.

abstract：:The anti-HIV drug 3'-azido-3'-deoxythymidine (AZT) is the drug of choice for preventing maternal-fetal HIV transmission during pregnancy. Our aim was to assess the cytotoxic effects of AZT on human placenta in vitro. The mechanisms of AZT-induced effects were investigated using JEG-3 choriocarcinoma cells and primary ...

journal_title：Toxicology and applied pharmacology

authors： Collier AC,Helliwell RJ,Keelan JA,Paxton JW,Mitchell MD,Tingle MD

更新日期：2003-10-15 00:00:00

abstract：:Changes in body weight, feed intake, hepatic cellularity, and intermediary metabolism were assessed in the mature male (450 g) rat following 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administration. All animals were schedule-fed (8-hr feeding period/24 hr) and treated with a single oral dose of either TCDD (75 microg...

journal_title：Toxicology and applied pharmacology

authors： Christian BJ,Menahan LA,Peterson RE

更新日期：1986-04-01 00:00:00

abstract：:Endothelial apoptosis is a driving force in atherosclerosis development. Oxidized low-density lipoprotein (oxLDL) promotes inflammatory and thrombotic processes and is highly atherogenic, as it stimulates macrophage cholesterol accumulation and foam cell formation. Previous studies have shown that the phosphatidylinos...

journal_title：Toxicology and applied pharmacology

authors： Ou HC,Lee WJ,Lee SD,Huang CY,Chiu TH,Tsai KL,Hsu WC,Sheu WH

更新日期：2010-10-15 00:00:00

abstract：:This study assessed the role of aryl hydrocarbon receptor (AHR) affinity, and cytochrome P4501A (CYP1A) protein and activity in polyaromatic hydrocarbon (PAH)-induced oxidative stress. In the 1-100nM concentration range benzo[a]pyrene (BaP) but not benzo[e]pyrene (BeP) competitively displaced 2nM [(3)H]2, 3, 7, 8-tetr...

journal_title：Toxicology and applied pharmacology

authors： Curtis LR,Garzon CB,Arkoosh M,Collier T,Myers MS,Buzitis J,Hahn ME

更新日期：2011-07-01 00:00:00

abstract：:The mechanism of action of Cd on Na,K-ATPase was investigated in two "classical" model systems, the shark rectal gland and rabbit kidney outer medulla. In lyophilized plasma membranes from dogfish rectal gland Cd inhibited Na,K-ATPase activity after 30 min of preincubation with an I50 of 1.3 x 10(-5) M. K-Dependent p-...

journal_title：Toxicology and applied pharmacology

authors： Kinne-Saffran E,Hülseweh M,Pfaff C,Kinne RK

更新日期：1993-07-01 00:00:00

abstract：:In the metabolism of isosorbide dinitrate (ISDN), fast denitration with the formation of nitrite ions and a mononitrate plays an important role. In contrast, the denitration of isosorbide-5-mononitrate (IS-5-MN) to isosorbide is very slow. Accordingly po administration of high doses of ISDN (92.5 and 236 mg/kg) in con...

journal_title：Toxicology and applied pharmacology

authors： Strein K,Bartsch W,Sponer G,Müller-Beckmann B,Lexa P

更新日期：1984-01-01 00:00:00

abstract：:A physiologically based model of lead absorption and disposition, previously developed and validated for adults, has been tested and calibrated for children. The model was modified to incorporate additional information on the age dependence of bone formation rate and to take into account increasing localization of bon...

journal_title：Toxicology and applied pharmacology

authors： O'Flaherty EJ

更新日期：1995-04-01 00:00:00

abstract：:As a part of the serotoninergic dysfunction implicated in neurobiology of depression, evidence has focused on serotonin (5-HT) receptors downstream signaling intermediates including glycogen synthase kinase-3β (GSK-3β), cAMP response element binding protein (CREB) and brain derived neurotrophic factor (BDNF). Our team...

journal_title：Toxicology and applied pharmacology

authors： Abuelezz SA,Hendawy N,Magdy Y

更新日期：2018-02-01 00:00:00

abstract：:The pharmacokinetics of methanol and formate were characterized in male Fischer-344 rats and rhesus monkeys exposed to methanol vapor concentrations between 50 and 2000 ppm for 6 hr. End-of-exposure blood methanol concentrations were not directly proportional to the atmospheric concentration. The methanol exposures di...

journal_title：Toxicology and applied pharmacology

authors： Horton VL,Higuchi MA,Rickert DE

更新日期：1992-11-01 00:00:00

abstract：:Arsenic is an environmental toxicant and carcinogen. Exposure to arsenic is associated with development of liver fibrosis and portal hypertension through ill defined mechanisms. We evaluated hepatic fibrogenesis after long term arsenic exposure in a murine model. BALB/c mice were exposed to arsenic by daily gavages of...

journal_title：Toxicology and applied pharmacology

authors： Ghatak S,Biswas A,Dhali GK,Chowdhury A,Boyer JL,Santra A

更新日期：2011-02-15 00:00:00

abstract：:Acute oral toxicity of Cd (as cadmium chloride) was enhanced in rats fasted 24 hr, as shown by a markedly decreased LD50. To examine the relationship among Cd toxicity, hepatic glutathione (GSH), and metallothionein (MT) during fasting, rats were administered 75 mg Cd/kg orally 24 hr after fasting and euthanized after...

journal_title：Toxicology and applied pharmacology

authors： Shimizu M,Morita S

更新日期：1990-03-15 00:00:00

abstract：:In vitro studies showed that 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) increases P-glycoprotein (P-gp) expression and activity in Caco-2 cells, preventing xenobiotic toxicity. The present study aimed at investigating TX5 effects on P-gp expression/activity using Wistar Han rats: a) in vivo, evaluating ...

journal_title：Toxicology and applied pharmacology

authors： Rocha-Pereira C,Ghanem CI,Silva R,Casanova AG,Duarte-Araújo M,Gonçalves-Monteiro S,Sousa E,Bastos ML,Remião F

更新日期：2020-01-01 00:00:00

abstract：:A pressing need exists to develop and validate molecular biomarkers to assess the early effects of chemical agents, both individually and in mixtures. This is particularly true for new and chemically intensive industries such as the semiconductor industry. Previous studies from this laboratory and others have demonstr...

journal_title：Toxicology and applied pharmacology

authors： Fowler BA,Conner EA,Yamauchi H

更新日期：2005-08-07 00:00:00

abstract：:Mycotoxin citrinin (CTN) is commonly found in foods and feeds that are contaminated/inoculated with Penicillium, Aspergillus and Monascus species. The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein ki...

journal_title：Toxicology and applied pharmacology

authors： Chang CH,Yu FY,Wang LT,Lin YS,Liu BH

更新日期：2009-06-15 00:00:00

abstract：:Toxicological and biochemical effects of muconaldehyde, a six-carbon diene dialdehyde, were evaluated in 6- to 9-week-old CD-1 male mice. The LD50 of trans,trans-muconaldehyde was 6.7 and 7.1 mg/kg body wt when calculated by two different methods. Administration of trans,trans-muconaldehyde (2 mg/kg, ip) daily for 10 ...

journal_title：Toxicology and applied pharmacology

authors： Witz G,Rao GS,Goldstein BD

更新日期：1985-09-30 00:00:00

abstract：:The Zrt/Irt-related protein 8 (ZIP8) encoded by slc39a8 is now emerging as an important zinc transporter involved in cellular cadmium incorporation. We have previously shown that mRNA and protein levels of ZIP8 were decreased in cadmium-resistant metallothionein-null (A7) cells, leading to a decrease in cadmium accumu...

journal_title：Toxicology and applied pharmacology

authors： Fujishiro H,Okugaki S,Yasumitsu S,Enomoto S,Himeno S

更新日期：2009-12-01 00:00:00

abstract：:A great number of people are suffering from allergic inflammatory disease such as asthma, atopic dermatitis, and sinusitis. Therefore discovery of drugs for the treatment of these diseases is an important subject in human health. Putranjivain A (PJA), member of ellagitannin, is known to possess beneficial effects incl...

journal_title：Toxicology and applied pharmacology

authors： Kim HH,Park SB,Lee S,Kwon TK,Shin TY,Park PH,Lee SH,Kim SH

更新日期：2014-02-01 00:00:00

abstract：:Chemotherapy is one of the major strategies for cancer treatment. Several antineoplastic drugs including vinorelbine (VRB) are commonly intravenously infused and liable to cause serious phlebitis. The therapeutic drugs for preventing this complication are limited. In this study, the mechanism of baicalein (BCN) was in...

journal_title：Toxicology and applied pharmacology

authors： Ge GF,Shi WW,Yu CH,Jin XY,Zhang HH,Zhang WY,Wang LC,Yu B

更新日期：2017-03-01 00:00:00

abstract：:High- and low- Se diets received by dams during gestation and lactation are related to insulin resistance in their pups. High-Se diet leads to an increase in serum insulin levels, which does not function properly, and an anabolic process. Low-Se diet is related to very low insulin values and an extreme catabolic energ...

journal_title：Toxicology and applied pharmacology

authors： Ojeda ML,Carreras O,Díaz-Castro J,Murillo ML,Nogales F

更新日期：2019-11-01 00:00:00

abstract：:It has been known for many years that administration of androgens or estrogens at critical periods of development in mammals causes severe long-term effects on the endocrine/genital systems. The environmental pollutant p-tert-octylphenol (OP) possesses a weak but clear estrogen agonist activity in in vitro and in vivo...

journal_title：Toxicology and applied pharmacology

authors： Katsuda S,Yoshida M,Watanabe G,Taya K,Maekawa A

更新日期：2000-06-15 00:00:00

abstract：:Inhibition of intercellular communication, as measured by metabolic cooperation between 6-thioguanine-sensitive and 6-thioguanine-resistant Chinese hamster V79 cells, has been previously shown to be correlated with a large variety of known tumor promoters, including some of the organochlorine pesticides. Since further...

journal_title：Toxicology and applied pharmacology

authors： Lin ZX,Kavanagh T,Trosko JE,Chang CC

更新日期：1986-03-30 00:00:00

abstract：:Studies were conducted which examined urinary excretion and papillary production of cyclic-AMP in the rat following vasopressin (ADH) stimulation in the presence or absence of inorganic fluoride ion (F). In one set of experiments, six anesthetized Fischer 344 rats were administered 5 munits arginine vasopressin during...

journal_title：Toxicology and applied pharmacology

authors： Maxwell JA,Caffrey JL,Yorio T,Sinclair RJ

更新日期：1983-06-15 00:00:00

abstract：:The goodness of fit of three PBPK models to data for inhalation uptake of 1,3-butadiene by mice from closed chambers were compared. These models included a classical flow-limited model with blood consolidated into arterial and venous compartments, a flow-limited model with implicit blood and alveolar compartments, and...

journal_title：Toxicology and applied pharmacology

authors： Kohn MC

更新日期：1997-12-01 00:00:00

abstract：:Cholestatic liver injury is caused by hepatocellular apoptosis induced by toxic bile salts. We have studied the effects of a traditional Chinese herbal medicine, Salvia miltiorrhiza, on apoptotic cell death in bile duct-ligated (BDL) rats. We also attempted to clarify the molecular mechanisms of the hepatoprotective e...

journal_title：Toxicology and applied pharmacology

authors： Oh SH,Nan JX,Sohn D-,Kim YC,Lee BH

更新日期：2002-07-01 00:00:00

abstract：:6-Hydroxy-trans,trans-2,4-hexadienal (CHO-M-OH) is a metabolite of trans,trans-muconaldehyde (muconaldehyde or MUC), a microsomal hematotoxic ring-opened metabolite of benzene. In the present study, the toxicity of CHO-M-OH was examined. In order to assess potential toxic effects of CHO-M-OH on the maturation of eryth...

journal_title：Toxicology and applied pharmacology

authors： Zhang Z,Schafer F,Schoenfeld H,Cooper K,Snyder R,Goldstein BD,Witz G

更新日期：1995-06-01 00:00:00

abstract：:2,5-Hexanedione (HD) produces a neurofilamentous axonpathy in humans and experimental animals. The present study was carried out to determine the time course of the effects of HD on muscle spindle position sensitivity to permit comparisons with similar effects of other toxicants which produce a neurofilamentous axonop...

journal_title：Toxicology and applied pharmacology

authors： de Rojas TC,Goldstein BD

更新日期：1990-04-01 00:00:00

abstract：:Human exposure to bisphenol A is controversially discussed. This review critically assesses methods for biomonitoring of bisphenol A exposures and reported concentrations of bisphenol A in blood and urine of non-occupationally ("environmentally") exposed humans. From the many methods published to assess bisphenol A co...

journal_title：Toxicology and applied pharmacology

authors： Dekant W,Völkel W

更新日期：2008-04-01 00:00:00

abstract：:Arsenate (AsV) is a structural analogue of phosphate (P(i)), yet its toxic effect is likely due to its reduction to the more toxic arsenite (AsIII), the mechanism of which is still unclear. Since mitochondria take up AsV as they do P(i), they may reduce AsV to AsIII. To test this hypothesis isolated rat liver mitochon...

journal_title：Toxicology and applied pharmacology

authors： Németi B,Gregus Z

更新日期：2002-08-01 00:00:00

abstract：:Air pollution, especially fine particulate matter (PM2.5, particles <2.5 μm in size), induces adverse health effects on the respiratory system. Uncontrolled proliferation of bronchial epithelial cells, resulting from deregulated cell cycle progression, contributes to pulmonary homeostatic imbalance. Although dysregula...

journal_title：Toxicology and applied pharmacology

authors： Xiao T,Ling M,Xu H,Luo F,Xue J,Chen C,Bai J,Zhang Q,Wang Y,Bian Q,Liu Q

更新日期：2019-08-15 00:00:00

abstract：:This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally...

journal_title：Toxicology and applied pharmacology

authors： Lhuguenot JC,Mitchell AM,Milner G,Lock EA,Elcombe CR

更新日期：1985-08-01 00:00:00