当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Induction of endoplasmic reticulum stress might be responsible for defective autophagy in cadmium-induced prostate carcinogenesis.

Induction of endoplasmic reticulum stress might be responsible for defective autophagy in cadmium-induced prostate carcinogenesis.

Abstract：

:Earlier, we reported that chronic cadmium (Cd)-exposure to prostate epithelial (RWPE-1) cells causes defective autophagy, which leads to the transformation of a malignant phenotype in both in vitro and in vivo models. However, the upstream events responsible for defective autophagy are yet to be delineated. The present study suggests that chronic Cd exposure induces endoplasmic reticulum (ER) stress that triggers the phosphorylation of stress transducers [protein kinase R-like ER Kinase- (PERK), eukaryotic translation initiation factor 2-alpha- (eIF2-α) and Activating Transcription Factor 4 -(ATF-4)], resulting in defective autophagy that protects Cd-exposed RWPE-1 cells. On the other hand, inhibition of the ATF4 stress inducer by siRNA blocked the Cd-induced defective autophagy in transforming cells. While dissecting the upstream activators of ER stress, we found that increased expression of reactive oxygen species (ROS) is responsible for ER stress in Cd-exposed RWPE-1 cells. Overexpression of antioxidants (SOD1/SOD2) mitigates Cd-induced ROS that results in inhibition of ER stress and autophagy in prostate epithelial cells. These results suggest that the induction of ROS and subsequent ER stress are responsible for defective autophagy in Cd-induced transformation in prostate epithelial cells.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Kolluru V,Tyagi A,Chandrasekaran B,Ankem M,Damodaran C

doi

10.1016/j.taap.2019.04.012

subject

Has Abstract

pub_date

2019-06-15 00:00:00

pages

62-68

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(19)30138-3

journal_volume

373

pub_type

杂志文章

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Effects of nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NONO-NSAIDs) on melanoma cell adhesion.

    abstract：:A new class of nitric oxide (NO•)-releasing nonsteroidal anti-inflammatory drugs (NONO-NSAIDs) were developed in recent years and have shown promising potential as NSAID substitutes due to their gentle nature on cardiovascular and gastrointestinal systems. Since nitric oxide plays a role in regulation of cell adhesion...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.07.029

    authors： Cheng H,Mollica MY,Lee SH,Wang L,Velázquez-Martínez CA,Wu S

    更新日期：2012-10-15 00:00:00

  • HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling.

    abstract：:Anoikis is defined as apoptosis, which is induced by inappropriate cell-matrix interactions. Cancer cells with anoikis resistance tend to undergo metastasis, and this phenomenon has been reported to be associated with integrin and FAK activity. HPW-RX40 is a derivative of 3,4-methylenedioxy-β-nitrostyrene, which is kn...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.09.011

    authors： Chen IH,Shih HC,Hsieh PW,Chang FR,Wu YC,Wu CC

    更新日期：2015-12-01 00:00:00

  • The NADPH oxidase inhibitor apocynin (acetovanillone) induces oxidative stress.

    abstract：:Apocynin (acetovanillone) is often used as a specific inhibitor of NADPH oxidase. In N11 glial cells, apocynin induced, in a dose-dependent way, a significant increase of both malonyldialdehyde level (index of lipid peroxidation) and lactate dehydrogenase release (index of a cytotoxic effect). Apocynin evoked also, in...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2005.07.011

    authors： Riganti C,Costamagna C,Bosia A,Ghigo D

    更新日期：2006-05-01 00:00:00

  • Persistence of calcium elevation in the HPB-ALL human T cell line correlates with immunosuppressive properties of polycyclic aromatic hydrocarbons.

    abstract：:The immunosuppressive synthetic methylated polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA), has been shown to cause both an immediate and a sustained elevation of free intracellular calcium (Ca2+) in human T cells. In the present studies, a series of anthracene- and pyrene-based PAHs were ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1994.1161

    authors： Krieger JA,Born JL,Burchiel SW

    更新日期：1994-08-01 00:00:00

  • Stress does not enable pyridostigmine to inhibit brain cholinesterase after parenteral administration.

    abstract：:The peripherally acting cholinesterase inhibitor pyridostigmine was widely used during the Gulf War as a pretreatment against possible chemical warfare attack. Following consistent reports on long-term illness among Gulf War veterans, pyridostigmine was examined for its possible long-term effects. These effects were s...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.2000.8906

    authors： Grauer E,Alkalai D,Kapon J,Cohen G,Raveh L

    更新日期：2000-05-01 00:00:00

  • A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors.

    abstract：:Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.01.017

    authors： Kumar R,Verma V,Sharma V,Jain A,Singh V,Sarswat A,Maikhuri JP,Sharma VL,Gupta G

    更新日期：2015-03-15 00:00:00

  • Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats.

    abstract：:Phenobarbital (PB) is an effective growth stimulator of hepatic hyperplastic nodules developed with diethylnitrosamine and 2-acetylaminofluorene plus partial hepatectomy (the Solt-Farber model), but it does not apparently stimulate the growth of preneoplastic lesions produced with aflatoxin B1 (AFB). Some studies have...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(91)90142-2

    authors： Chen ZY,Eaton DL

    更新日期：1991-10-01 00:00:00

  • The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth.

    abstract：:Several large epidemiological and animal studies demonstrate a direct correlation between dietary heme iron intake and/or systemic iron levels and cancer risk in several cancers including colorectal cancer (CRC). However, the precise mechanisms for how heme iron contributes to CRC and how cancer cells respond to heme ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.04.025

    authors： Kim H,Yin K,Falcon DM,Xue X

    更新日期：2019-07-01 00:00:00

  • Species differences in vacuolation of the choroid plexus induced by the piperidine-ring drug disobutamide in the rat, dog, and monkey.

    abstract：:A subchronic oral toxicity study of disobutamide, a piperidine ring compound with antiarrhythmic activity, was conducted at doses of 30, 100, and 250 mg/kg in rats, 45 mg/kg in dogs, and 90 mg/kg in monkeys. Numerous vacuoles were observed in various organs such as the liver, kidneys, heart, lungs, spleen, thymus, sto...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(86)90421-7

    authors： Koizumi H,Watanabe M,Numata H,Sakai T,Morishita H

    更新日期：1986-06-15 00:00:00

  • Analysis of the interaction of phytoestrogens and synthetic chemicals: an in vitro/in vivo comparison.

    abstract：:In the evaluation of chemical mixture toxicity, it is desirable to develop an evaluation paradigm which incorporates some critical attributes of real world exposures, particularly low dose levels, larger numbers of chemicals, and chemicals from synthetic and natural sources. This study evaluated the impact of low leve...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2006.11.029

    authors： Charles GD,Gennings C,Tornesi B,Kan HL,Zacharewski TR,Bhaskar Gollapudi B,Carney EW

    更新日期：2007-02-01 00:00:00

  • Reactive oxygen species mediate nitric oxide production through ERK/JNK MAPK signaling in HAPI microglia after PFOS exposure.

    abstract：:Perfluorooctane sulfonate (PFOS), an emerging persistent contaminant that is commonly encountered during daily life, has been shown to exert toxic effects on the central nervous system (CNS). However, the molecular mechanisms underlying the neurotoxicity of PFOS remain largely unknown. It has been widely acknowledged ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.06.012

    authors： Wang C,Nie X,Zhang Y,Li T,Mao J,Liu X,Gu Y,Shi J,Xiao J,Wan C,Wu Q

    更新日期：2015-10-15 00:00:00

  • Initial analyses of the relationship between "Thresholds" of toxicity for individual chemicals and "Interaction Thresholds" for chemical mixtures.

    abstract：:The inter-relationship of "Thresholds" between chemical mixtures and their respective component single chemicals was studied using three sets of data and two types of analyses. Two in vitro data sets involve cytotoxicity in human keratinocytes from treatment of metals and a metal mixture [Bae, D.S., Gennings, C., Cart...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2006.11.016

    authors： Yang RS,Dennison JE

    更新日期：2007-09-01 00:00:00

  • Trichloroethene-induced autoimmune response in female MRL +/+ mice.

    abstract：:Trichloroethene (TCE) has been implicated in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE) and scleroderma in humans. However, experimental studies have not been conducted to establish the role of TCE in causing autoimmunity and/or SLE. To clarify the role of TCE in autoimmune resp...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1995.1179

    authors： Khan MF,Kaphalia BS,Prabhakar BS,Kanz MF,Ansari GA

    更新日期：1995-09-01 00:00:00

  • A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells.

    abstract：:Cigarette smoke has been shown to cause gastric cancer. Overexpression of cyclooxygenase-2 (COX-2) is a common characteristic in gastric malignancy. The present study aimed to explore the correlation between cigarette smoke and COX-2 in the promotion of tumorigenesis in human gastric cancer cells (AGS). We further stu...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2003.10.009

    authors： Shin VY,Liu ES,Ye YN,Koo MW,Chu KM,Cho CH

    更新日期：2004-02-15 00:00:00

  • Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.

    abstract：:Endothelial apoptosis is a driving force in atherosclerosis development. Oxidized low-density lipoprotein (oxLDL) promotes inflammatory and thrombotic processes and is highly atherogenic, as it stimulates macrophage cholesterol accumulation and foam cell formation. Previous studies have shown that the phosphatidylinos...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2010.07.025

    authors： Ou HC,Lee WJ,Lee SD,Huang CY,Chiu TH,Tsai KL,Hsu WC,Sheu WH

    更新日期：2010-10-15 00:00:00

  • Increasing ERK phosphorylation by inhibition of p38 activity protects against cadmium-induced apoptotic cell death through ERK/Drp1/p38 signaling axis in spermatocyte-derived GC-2spd cells.

    abstract：:Many studies report that cadmium chloride (CdCl2)-induces oxidative stress is associated with male reproductive damage in the testes. CdCl2 also induces mitochondrial fission by increasing dynamin-related protein 1 (Drp1) expression as well as the mitochondria-dependent apoptosis pathway by extracellular signal-regula...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.114797

    authors： Seong JB,Bae YC,Lee HS,Huh JW,Lee SR,Lee HJ,Lee DS

    更新日期：2019-12-01 00:00:00

  • Epidermal CYP2 family cytochromes P450.

    abstract：:Skin is the largest and most accessible drug-metabolizing organ. In mammals, it is the competent barrier that protects against exposure to harmful stimuli in the environment and in the systemic circulation. Skin expresses many cytochromes P450 that have critical roles in exogenous and endogenous substrate metabolism. ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2003.09.020

    authors： Du L,Hoffman SM,Keeney DS

    更新日期：2004-03-15 00:00:00

  • Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog. III. Mechanisms of the dosimetry.

    abstract：:The disposition of polycyclic aromatic hydrocarbons (PAHs) in the respiratory tract of the Beagle dog was measured and presented in two previous papers. In this paper, the data were used to demonstrate that highly lipophilic toxicants, such as PAHs, were diffusion-limited during clearance from the respiratory tract. O...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1161

    authors： Gerde P,Muggenburg BA,Henderson RF

    更新日期：1993-08-01 00:00:00

  • Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

    abstract：:The Constitutive Androstane Receptor (CAR, NR1I3) has been newly described as a regulator of energy metabolism. A relevant number of studies using animal models of obesity suggest that CAR activation could be beneficial on the metabolic balance. However, this remains controversial and the underlying mechanisms are sti...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.05.006

    authors： Marmugi A,Lukowicz C,Lasserre F,Montagner A,Polizzi A,Ducheix S,Goron A,Gamet-Payrastre L,Gerbal-Chaloin S,Pascussi JM,Moldes M,Pineau T,Guillou H,Mselli-Lakhal L

    更新日期：2016-07-15 00:00:00

  • Inhibition of DNA topoisomerase I activity and induction of apoptosis by thiazacridine derivatives.

    abstract：:Thiazacridine derivatives (ATZD) are a novel class of cytotoxic agents that combine an acridine and thiazolidine nucleus. In this study, the cytotoxic action of four ATZD were tested in human colon carcinoma HCT-8 cells: (5Z)-5-acridin-9-ylmethylene-3-(4-methylbenzyl)-thiazolidine-2,4-dione - AC-4; (5ZE)-5-acridin-9-y...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2013.01.010

    authors： Barros FW,Bezerra DP,Ferreira PM,Cavalcanti BC,Silva TG,Pitta MG,de Lima Mdo C,Galdino SL,Pitta Ida R,Costa-Lotufo LV,Moraes MO,Burbano RR,Guecheva TN,Henriques JA,Pessoa C

    更新日期：2013-04-01 00:00:00

  • Chemical reactivity, cytotoxicity, and mutagenicity of chloropropanones.

    abstract：:Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP), and 1,3-dichloropropanone (1,3-DCP). Chloropropanones reacted directly with reduced glutathione (GSH) in sodium phosphate buffer at pH 7.4. All chloropropanones were cytotoxic t...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(87)90192-x

    authors： Merrick BA,Smallwood CL,Meier JR,McKean DL,Kaylor WH,Condie LW

    更新日期：1987-10-01 00:00:00

  • Nuclear penetration of surface functionalized gold nanoparticles.

    abstract：:Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA)...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.03.009

    authors： Gu YJ,Cheng J,Lin CC,Lam YW,Cheng SH,Wong WT

    更新日期：2009-06-01 00:00:00

  • Effects of 2,5-hexanedione on deefferented muscle spindle position sensitivity.

    abstract：:2,5-Hexanedione (HD) produces a neurofilamentous axonpathy in humans and experimental animals. The present study was carried out to determine the time course of the effects of HD on muscle spindle position sensitivity to permit comparisons with similar effects of other toxicants which produce a neurofilamentous axonop...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(90)90235-m

    authors： de Rojas TC,Goldstein BD

    更新日期：1990-04-01 00:00:00

  • Study on the toxic effects induced by different arsenicals in primary cultured rat astroglia.

    abstract：:Arsenic toxicity is a global health problem affecting millions of people. The objectives of this study were to determine if the toxic effects on primary cultured rat astroglia would be induced by different arsenicals. Based on alamarBlue assay and the single cell gel electrophoresis (SCGE, comet assay), the cell viabi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2004.01.015

    authors： Jin Y,Sun G,Li X,Li G,Lu C,Qu L

    更新日期：2004-05-01 00:00:00

  • Long-term exposure to nicotine markedly reduces kynurenic acid in rat brain--in vitro and ex vivo evidence.

    abstract：:Kynurenic acid (KYNA) is a recognized broad-spectrum antagonist of excitatory amino acid receptors with a particularly high affinity for the glycine co-agonist site of the N-methyl-D-aspartate (NMDA) receptor complex. KYNA is also a putative endogenous neuroprotectant. Recent studies show that KYNA strongly blocks alp...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.07.011

    authors： Zielińska E,Kuc D,Zgrajka W,Turski WA,Dekundy A

    更新日期：2009-10-15 00:00:00

  • Identification of potential endocrine disrupting chemicals using gene expression biomarkers.

    abstract：:Recent technological advances have moved the field of toxicogenomics from reliance on microarray platforms to high-throughput transcriptomic (HTTr) technologies that measure global gene expression. Gene expression biomarkers are emerging as useful tools for interpreting gene expression profiles to identify perturbatio...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2019.114683

    authors： Corton JC,Kleinstreuer NC,Judson RS

    更新日期：2019-10-01 00:00:00

  • Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1.

    abstract：:The multidrug resistance (MDR) transporter is a phosphorylated glycoprotein (P-gp) that has been implicated in the efflux of a large variety of xenobiotics, thereby protecting vital organs. This study examines the hypothesis that the multidrug resistance transporter is involved in restricting the entry of polychlorina...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0041-008x(02)00069-8

    authors： Tampal NM,Robertson LW,Srinivasan C,Ludewig G

    更新日期：2003-03-15 00:00:00

  • Involvement of reversible binding to alpha 2u-globulin in 1,4-dichlorobenzene-induced nephrotoxicity.

    abstract：:Similarly to unleaded gasoline, 1,4-dichlorobenzene (1,4-DCB) administered for 2 years caused a dose-related increase in the incidence of renal tumors in male but not in female rats or in either sex of mice. Unleaded gasoline and 2,2,4-trimethylpentane (TMP), a component of unleaded gasoline, increased protein droplet...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(89)90117-8

    authors： Charbonneau M,Strasser J Jr,Lock EA,Turner MJ Jr,Swenberg JA

    更新日期：1989-06-01 00:00:00

  • Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish.

    abstract：:Triclosan (TCS) is an antimicrobial agent commonly found in a variety of personal care products and cosmetics. TCS readily enters the environment through wastewater and is detected in human plasma, urine, and breast milk due to its widespread use. Studies have implicated TCS as a disruptor of thyroid and estrogen sign...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.08.013

    authors： Haggard DE,Noyes PD,Waters KM,Tanguay RL

    更新日期：2016-10-01 00:00:00

  • Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat.

    abstract：:The epithelial-mesenchymal transition (EMT) is a critical stage during the development of silicosis fibrosis. In the current study, we hypothesized that the anti-fibrotic tetrapeptide, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) may exert its anti-fibrotic effects via activation of the TGF-β1/ROCK1 pathway, leadin...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.01.010

    authors： Deng H,Xu H,Zhang X,Sun Y,Wang R,Brann D,Yang F

    更新日期：2016-03-01 00:00:00