Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the ED01 study.

abstract：:Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds. These compounds stimulate the development of steatohepatitis through their toxicity to hepatocyte mitochondria; inhibition of beta-oxidation, mitochondrial respiration, and/or oxidative phosphorylation. Other...

journal_title：Toxicology and applied pharmacology

authors： Schumacher JD,Guo GL

更新日期：2015-11-15 00:00:00

abstract：:Distance learning offers many advantages to students and teachers of almost any scientific discipline. Toxicology is no exception. For example, should Paracelsus be interested in learning more about toxicology at Drexel University, he would have the opportunity to take two courses in this subject utilizing the content...

journal_title：Toxicology and applied pharmacology

authors： Huggins J,Morris J,Peterson CE

更新日期：2005-09-01 00:00:00

abstract：:Ethanolic extract of Casearia sylvestris is thought to be antimutagenic. In this study, we attempted to determine whether this extract and casearin X (a clerodane diterpene from C. sylvestris) are protective against the harmful effects of airborne pollutants from sugarcane burning. To that end, we used the Tradescanti...

journal_title：Toxicology and applied pharmacology

authors： Prieto AM,Santos AG,Csipak AR,Caliri CM,Silva IC,Arbex MA,Silva FS,Marchi MR,Cavalheiro AJ,Silva DH,Bolzani VS,Soares CP

更新日期：2012-12-15 00:00:00

abstract：:A clinical study was performed to determine the effects of patch testing human skin with four industrially used surfactants on erythema formation, transepidermal water loss, and the contents in suction blister fluids of primary proinflammatory mediators including arachidonic acid, eicosanoids, and IL-1 alpha, which we...

journal_title：Toxicology and applied pharmacology

authors： Müller-Decker K,Heinzelmann T,Fürstenberger G,Kecskes A,Lehmann WD,Marks F

更新日期：1998-11-01 00:00:00

abstract：:Arsenic compounds are classified as toxicants and human carcinogens. Environmental exposure to arsenic imposes a big health issue worldwide. Arsenic elicits its toxic efforts through many mechanisms, including generation of reactive oxygen species (ROS). Nrf2 is the primary transcription factor that controls expressio...

journal_title：Toxicology and applied pharmacology

authors： Jiang T,Huang Z,Chan JY,Zhang DD

更新日期：2009-10-01 00:00:00

abstract：:The Bcl-2 family contains a panel of proteins which are conserved regulators of apoptosis in mammalian cells, like the anti-apoptotic protein Bcl-2. According to its significant role in altering susceptibility to apoptosis, the deciphering of the mechanism of Bcl-2 expression modulation may be crucial for identifying ...

journal_title：Toxicology and applied pharmacology

authors： Liang X,Xu K,Xu Y,Liu J,Qian X

更新日期：2011-10-01 00:00:00

abstract：:The effect of captopril, an angiotensin-converting enzyme inhibitor, on the progression of chronic renal disease was studied in rats subjected to partial nephrectomy. Following ablation of approximately 70% of their renal mass, rats were divided into three treatment groups: group I received a placebo treatment; group ...

journal_title：Toxicology and applied pharmacology

authors： Hall RL,Wilke WL,Fettman MJ

更新日期：1985-09-30 00:00:00

abstract：:Teratogenicity of the anticonvulsant phenytoin may be due in part to its bioactivation by prostaglandin synthetase, forming a reactive free radical intermediate. We examined whether teratogenicity of the structurally similar oxazolidinedione anticonvulsants, trimethadione and its N-demethylated metabolite dimethadione...

journal_title：Toxicology and applied pharmacology

authors： Wells PG,Nagai MK,Greco GS

更新日期：1989-03-01 00:00:00

abstract：:Along with hepatotoxicity, cardiotoxic side effects remain one of the major reasons for drug withdrawals and boxed warnings. Prediction methods for cardiotoxicity are insufficient. High content screening comprising of not only electrophysiological characterization but also cellular molecular alterations are expected t...

journal_title：Toxicology and applied pharmacology

authors： Strigun A,Wahrheit J,Beckers S,Heinzle E,Noor F

更新日期：2011-04-15 00:00:00

abstract：:The effects of the chemical species and concentration of selenium (Se) in diets on the concentrations of Se in hair, blood serum, red blood cells (RBCs), and urine were studied to gain an insight into the toxicological and nutritional significance of different chemical forms of Se. Male Wistar rats were fed an Se-defi...

journal_title：Toxicology and applied pharmacology

authors： Shiobara Y,Yoshida T,Suzuki KT

更新日期：1998-10-01 00:00:00

abstract：:Isolated rat lymphocytes in salts-glucose medium (pH 7.2) were incubated with nickel chloride, nickel acetate, nickel sulfate, and a soluble form of nickel subsulfide (0-2 mM) at 37 degrees C for 2 h. The soluble form of nickel subsulfide induced a significant increase in DNA-protein crosslinks (DPXLs) (111%) beginnin...

journal_title：Toxicology and applied pharmacology

authors： Chakrabarti SK,Bai C,Subramanian KS

更新日期：2001-02-01 00:00:00

abstract：:Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3...

journal_title：Toxicology and applied pharmacology

authors： Kumar R,Verma V,Sharma V,Jain A,Singh V,Sarswat A,Maikhuri JP,Sharma VL,Gupta G

更新日期：2015-03-15 00:00:00

abstract：:Nanotechnology has the potential to make a beneficial impact on several agricultural, forestry, and environmental challenges, such as urbanization, energy constraints, and sustainable use of resources. However, new environmental and human health hazards may emerge from nano-enhanced applications. This raises concerns ...

journal_title：Toxicology and applied pharmacology

authors： Iavicoli I,Leso V,Beezhold DH,Shvedova AA

更新日期：2017-08-15 00:00:00

abstract：:Aromatase inhibitors like anastrozole play an undisputed key role in the treatment of breast cancer, but on the other hand, various side effects like osteoporosis and increased risk of bone fracture accompany the chronic administration of these drugs. Here we show for the first time that selenium nanoparticles, when g...

journal_title：Toxicology and applied pharmacology

authors： Vekariya KK,Kaur J,Tikoo K

更新日期：2013-04-15 00:00:00

abstract：:Two lines of evidence support the concept that cardiotoxin from Naja naja siamensis interacts directly with the plasma membrane to produce selective cytolysis of lymphocytes. Toxin adsorbed to the wells of microtiter plates retained the ability to lyse murine T-lymphocytes, but lost the ability to destroy natural kill...

journal_title：Toxicology and applied pharmacology

authors： Hinman CL,Jiang XL,Tang HP

更新日期：1990-06-15 00:00:00

abstract：:Methyl chloride (MeCl) metabolism and pharmacokinetics were studied in male Fischer 344 rats and male beagle dogs. Apparent steady-state blood MeCl concentrations were proportionate to exposure concentration in rats and dogs exposed to 50 and 1000 ppm. Furthermore, blood MeCl concentrations were similar in both specie...

journal_title：Toxicology and applied pharmacology

authors： Landry TD,Gushow TS,Langvardt PW,Wall JM,McKenna MJ

更新日期：1983-05-01 00:00:00

abstract：:The industrial solvent ethylene glycol monomethyl ether (EGME) is a known teratogen that has been reported to alter calcium metabolism in guinea pigs during chronic exposure. Because of the tremendous demand of reproduction on maternal calcium stores, the effects of EGME on calcium and vitamin D metabolism during gest...

journal_title：Toxicology and applied pharmacology

authors： Toraason M,Niemeier RW,Hardin BD

更新日期：1986-11-01 00:00:00

abstract：:The teleost swim bladder is assumed a homolog of the tetrapod lung. Both swim bladder and lung are developmental targets of persistent aryl hydrocarbon receptor (AHR(2)) agonists; in zebrafish (Danio rerio) the swim bladder fails to inflate with exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126). The mechanism for t...

journal_title：Toxicology and applied pharmacology

authors： Jönsson ME,Kubota A,Timme-Laragy AR,Woodin B,Stegeman JJ

更新日期：2012-12-01 00:00:00

abstract：:A previously developed PBPK model for ethylene glycol and glycolic acid was extended to include glyoxylic acid, oxalic acid, and the precipitation of calcium oxalate that is associated with kidney toxicity in rats and humans. The development and evaluation of the PBPK model was based upon previously published pharmaco...

journal_title：Toxicology and applied pharmacology

authors： Corley RA,Saghir SA,Bartels MJ,Hansen SC,Creim J,McMartin KE,Snellings WM

更新日期：2011-02-01 00:00:00

abstract：:Organic UV filters including benzophenone-3 (BP-3) are widely used to protect humans and materials from damage by UV irradiation. Despite the environmental occurrence of BP-3 in the aquatic environment, little is known about its effects and modes of action. In the present study we assess molecular and physiological ef...

journal_title：Toxicology and applied pharmacology

authors： Blüthgen N,Zucchi S,Fent K

更新日期：2012-09-01 00:00:00

abstract：:To characterize modes of action of substances and their cytotoxic effects Bionas GmbH has developed a new screening system to allow the continuous recording of how an active substance can act (Bionas 2500 analyzing system). In the pharmaceutical industry it is important to acquire as much information as possible about...

journal_title：Toxicology and applied pharmacology

authors： Thedinga E,Kob A,Holst H,Keuer A,Drechsler S,Niendorf R,Baumann W,Freund I,Lehmann M,Ehret R

更新日期：2007-04-01 00:00:00

abstract：:We developed an in vivo model for cadmium-induced bone loss in which mice excrete bone mineral in feces beginning 8 h after cadmium gavage. Female mice of three strains [CF1, MTN (metallothionein-wild-type), and MT1,2KO (MT1,2-deficient)] were placed on a low-calcium diet for 2 weeks. Each mouse was gavaged with 200 m...

journal_title：Toxicology and applied pharmacology

authors： Regunathan A,Glesne DA,Wilson AK,Song J,Nicolae D,Flores T,Bhattacharyya MH

更新日期：2003-09-15 00:00:00

abstract：:We describe a compartmental pharmacokinetic model for methyl mercury and its metabolite mercuric mercury in humans. A tracer dose of 203Hg-labeled methyl mercury was administered iv to seven healthy young adult male volunteers. Blood samples were obtained periodically and urine and feces were collected throughout the ...

journal_title：Toxicology and applied pharmacology

authors： Smith JC,Allen PV,Turner MD,Most B,Fisher HL,Hall LL

更新日期：1994-10-01 00:00:00

abstract：:A discrete-time simulation model of carcinogenesis is described mathematically using recursive relationships between time-varying model variables. The dynamics of cellular behavior is represented within a biological framework that encompasses two irreversible and heritable genetic changes. Empirical data and biologica...

journal_title：Toxicology and applied pharmacology

authors： Ellwein LB,Cohen SM

更新日期：1992-03-01 00:00:00

abstract：:The mechanism by which acrylamide (ACR) produces distal axonopathy in humans and laboratory animals is unknown. The possibility that this neuropathy involves deregulation of elements and water in rat peripheral nerve has been investigated. Electron probe X-ray microanalysis was used to measure percentages of water and...

journal_title：Toxicology and applied pharmacology

authors： LoPachin RM,Castiglia CM,Saubermann AJ

更新日期：1992-07-01 00:00:00

abstract：:Hepatic expression of the proinflammatory cytokine tumor necrosis factor-alpha (TNFalpha) occurs in many acute and chronic liver diseases, as well as following exposure to hepatotoxic chemicals, and is believed to help influence both the damage and repair processes that occur following these insults by regulating addi...

journal_title：Toxicology and applied pharmacology

authors： Simeonova PP,Gallucci RM,Hulderman T,Wilson R,Kommineni C,Rao M,Luster MI

更新日期：2001-12-01 00:00:00

abstract：:Contamination of animal feed with mycotoxins is a major problem for fish feed mainly due to usage of contaminated ingredients for production and inappropriate storage of feed. The use of cereals for fish food production further increases the risk of a potential contamination. Potential contaminants include the mycotox...

journal_title：Toxicology and applied pharmacology

authors： Pietsch C,Bucheli TD,Wettstein FE,Burkhardt-Holm P

更新日期：2011-10-01 00:00:00

abstract：:Interferon α (IFNα) is used to treat malignancies and chronic viral infections. It has been found to decrease the rate of drug metabolism by acting on cytochrome P450 enzymes, but no studies have investigated the consequences of IFNα treatment on the CYP3A4 isoform, responsible for the metabolism of a majority of drug...

journal_title：Toxicology and applied pharmacology

authors： Flaman AS,Gravel C,Hashem AM,Tocchi M,Li X

更新日期：2011-06-01 00:00:00

abstract：:The effect of cadmium injection on the high-affinity phlorizin binding to renal outer cortical brush-border membranes was studied in rabbits. Animals received subcutaneous injections of CdCl2 at a dose of 3 mg Cd/kg.day for about 3 weeks. Brush-border membranes were isolated from renal outer cortex by Percoll gradient...

journal_title：Toxicology and applied pharmacology

authors： Kim KR,Park YS

更新日期：1995-08-01 00:00:00

abstract：:Renal glutathione (GSH) concentrations were reduced approximately 80% at 4 hr after a single injection of buthionine sulfoxime (BSO) (4 mmol/kg body wt) and remained reduced for at least 16 hr in male rats. Following BSO injection, rats were injected with a nephrotoxic dose of cadmium-metallothionein (Cd-MT) (0.3 mg C...

journal_title：Toxicology and applied pharmacology

authors： Suzuki CA,Cherian MG

更新日期：1989-05-01 00:00:00