Ferritin and in vivo beryllium toxicity.

Abstract:

:Beryllium (Be+2), a divalent metal ion, is toxic to both man and animal. Although the molecular basis for its toxicity is unknown, it is well established that micromolar concentrations of beryllium specifically inhibit certain enzymes. Previous in vitro studies have shown that the presence of ferritin, an iron-storage protein, reactivated these enzymes by sequestering beryllium (Price and Joshi, 1984). In the present study we demonstrate in vivo that beryllium and zinc are bound by ferritin in greater amounts than Pb+2, Cu+2, and Cd+2. Beryllium did not induce the synthesis of metallothionein. In animals pretreated with an iron salt (ferric ammonium citrate, 40 mg/kg body wt), liver ferritin was elevated approximately five times and the toxicity of intravenously injected beryllium was significantly attenuated. Excretion and deposition studies suggested that iron salt treatment resulted in a reduction of liver beryllium. Thus the protection against beryllium toxicity by ferric ammonium citrate may be due to increased production of ferritin which binds beryllium and its subsequent elimination in the feces.

journal_name

Toxicol Appl Pharmacol

authors

Lindenschmidt RC,Sendelbach LE,Witschi HP,Price DJ,Fleming J,Joshi JG

doi

10.1016/0041-008x(86)90211-5

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

344-50

issue

2

eissn

0041-008X

issn

1096-0333

pii

0041-008X(86)90211-5

journal_volume

82

pub_type

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