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Biochemical and neuropathological assessment of triphenyl phosphite in rats.

Abstract：

:The putative neurotoxicity of the organophosphorus compound triphenyl phosphite (TPP) was examined in Long Evans, adult male rats. Animals were exposed to two 1.0 ml/kg (1184 mg/kg) injections (sc) of TPP spaced 1 week apart and sampled for biochemical and neuropathological examination. At the time of sampling, rats displayed dysfunctional changes including tail rigidity, circling, and hindlimb paralysis. Neuropathic damage was confined to the lateral and ventral columns of all spinal levels and consisted of myelin ellipsoids and giant axonal swellings filled with smooth endoplasmic reticulum. Wallerian-like degeneration was observed in the spinal roots, the sciatic nerve, and tibial branches. Biochemical assessment of brain acetylcholinesterase (AChE) and neurotoxic esterase (NTE) activity was determined 1, 4, 24, 48, and 72 hr after the second TPP treatment. Both enzyme activity concentrations were depressed maximally at 48 hr postexposure by 30 and 39%, respectively. Serum cholinesterase, sampled 48 hr after the second TPP exposure was depressed by 33%. Data from this study indicate that subchronic exposure to the organophosphite TPP results in severe neurotoxic consequences which differ from those previously described in rats with organophosphorus-induced delayed neuropathy.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Veronesi B,Padilla S,Newland D

doi

10.1016/0041-008x(86)90297-8

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

203-10

issue

2

eissn

0041-008X

issn

1096-0333

pii

0041-008X(86)90297-8

journal_volume

83

pub_type

杂志文章

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