Substrate preference of a cytosolic aldehyde dehydrogenase inducible in rat liver by treatment with 3-methylcholanthrene.

abstract：INTRODUCTION:Noncirrhotic portal fibrosis has been reported to occur in humans due to prolonged intake of arsenic contaminated water. Further, oxystress and hepatic fibrosis have been demonstrated by us in chronic arsenic induced hepatic damage in murine model. Cytokines like tumor necrosis factor alpha (TNF-alpha) and...

journal_title：Toxicology and applied pharmacology

authors： Das S,Santra A,Lahiri S,Guha Mazumder DN

更新日期：2005-04-01 00:00:00

abstract：:Molecule-targeted therapies like those against the epidermal growth factor receptor (EGFR) are becoming widely used in the oncology clinic. With improvements in treatment efficacy, many cancers are being treated as chronic diseases, with patients having prolonged exposure to several therapies that were previously only...

journal_title：Toxicology and applied pharmacology

authors： Barrick CJ,Yu M,Chao HH,Threadgill DW

更新日期：2008-05-01 00:00:00

abstract：:Deltamethrin, a widely used type II pyrethroid insecticide, is a relatively potent neurotoxicant. While the toxicity has been extensively examined, toxicokinetic studies of deltamethrin and most other pyrethroids are very limited. The aims of this study were to identify, characterize, and assess the relative contribut...

journal_title：Toxicology and applied pharmacology

authors： Anand SS,Bruckner JV,Haines WT,Muralidhara S,Fisher JW,Padilla S

更新日期：2006-04-15 00:00:00

abstract：:Acetaminophen (APAP) and 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) each produced a similar incidence of, as well as a qualitatively similar, abnormal closure of the anterior neuropore at similar concentrations when added to the medium of cultured rat embryos. At concentrations producing a 50-65% incidence of abnormal...

journal_title：Toxicology and applied pharmacology

authors： Stark KL,Harris C,Juchau MR

更新日期：1989-03-01 00:00:00

abstract：:Studies were conducted which examined urinary excretion and papillary production of cyclic-AMP in the rat following vasopressin (ADH) stimulation in the presence or absence of inorganic fluoride ion (F). In one set of experiments, six anesthetized Fischer 344 rats were administered 5 munits arginine vasopressin during...

journal_title：Toxicology and applied pharmacology

authors： Maxwell JA,Caffrey JL,Yorio T,Sinclair RJ

更新日期：1983-06-15 00:00:00

abstract：:There is a subpopulation of the CF-1 mouse strain that is very sensitive to the neurotoxicity induced by the avermectins, a class of natural products widely used in veterinary and human medicine as anti-parasitic agents. This sensitivity results from a lack of P-glycoprotein in the intestine and brain of sensitive ani...

journal_title：Toxicology and applied pharmacology

authors： Umbenhauer DR,Lankas GR,Pippert TR,Wise LD,Cartwright ME,Hall SJ,Beare CM

更新日期：1997-09-01 00:00:00

abstract：:We describe a compartmental pharmacokinetic model for methyl mercury and its metabolite mercuric mercury in humans. A tracer dose of 203Hg-labeled methyl mercury was administered iv to seven healthy young adult male volunteers. Blood samples were obtained periodically and urine and feces were collected throughout the ...

journal_title：Toxicology and applied pharmacology

authors： Smith JC,Allen PV,Turner MD,Most B,Fisher HL,Hall LL

更新日期：1994-10-01 00:00:00

abstract：:Clofibric acid (CA), a potent peroxisome proliferator (PP), has been shown to cause tumor formation in rat liver. The precise mechanism of action of PPs remains largely unknown. However, it has been proposed that they act by increasing reactive oxygen species (ROS), leading to a cellular oxidative stress. In the prese...

journal_title：Toxicology and applied pharmacology

authors： Bécuwe P,Bianchi A,Dauça M

更新日期：2001-08-01 00:00:00

abstract：:Biochemical, functional and morphologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hearts of female rats were examined. Six days after the treatment of rats with TCDD, the blood pressures and resting heart rates were significantly less than in control animals. Treated animals were also less responsiv...

journal_title：Toxicology and applied pharmacology

authors： Hermansky SJ,Holcslaw TL,Murray WJ,Markin RS,Stohs SJ

更新日期：1988-09-15 00:00:00

abstract：:Juglone (5-hydroxy-1,4-naphtoquinone) is a natural toxin produced by walnut trees. In this study we show that juglone differentially reduces viability of human cells in culture. Normal fibroblast were found to be especially sensitive to juglone and lost viability primarily through a rapid apoptotic and necrotic respon...

journal_title：Toxicology and applied pharmacology

authors： Paulsen MT,Ljungman M

更新日期：2005-11-15 00:00:00

abstract：:Herb-drug interaction strongly limits the clinical application of herbs and drugs, and the inhibition of herbal components towards important drug-metabolizing enzymes (DMEs) has been regarded as one of the most important reasons. The present study aims to investigate the inhibition potential of andrographolide derivat...

journal_title：Toxicology and applied pharmacology

authors： Ma HY,Sun DX,Cao YF,Ai CZ,Qu YQ,Hu CM,Jiang C,Dong PP,Sun XY,Hong M,Tanaka N,Gonzalez FJ,Ma XC,Fang ZZ

更新日期：2014-05-15 00:00:00

abstract：:Exposure to airborne particulate matter (PM) is associated with increased mortality and morbidity. It has been previously shown that PMs and synthetic particles (PC10 and PC2) that have similar characteristics to PMs induced depolarizing currents and increases in intracellular calcium ([Ca2+]i) in capsaicin- and acid-...

journal_title：Toxicology and applied pharmacology

authors： Agopyan N,Bhatti T,Yu S,Simon SA

更新日期：2003-10-01 00:00:00

abstract：:A series of psychopharmacological agents were administered to adult male Fischer-344 rats pretreated with a tremorigenic dose of chlordecone in an attempt to elucidate the involvement of spinal and supraspinal processes in the mediation and/or expression of chlordecone-induced tremor. Agents effective in attenuating t...

journal_title：Toxicology and applied pharmacology

authors： Gerhart JM,Hong JS,Tilson HA

更新日期：1983-09-30 00:00:00

abstract：:Protein phosphatase 2A (PP2A) is a serine-threonine phosphatase that regulates cell signaling pathways. Its inactivation is correlated with tumor malignancy, possibly due to the effects on cell differentiation and malignant cell transformation. Therefore, it has been noted that PP2A could be a promising target for can...

journal_title：Toxicology and applied pharmacology

authors： Ishii Y,Kuroda K,Matsushita K,Yokoo Y,Takasu S,Kijima A,Nohmi T,Ogawa K,Umemura T

更新日期：2017-12-01 00:00:00

abstract：:Liver fibrosis results from chronic tissue damage and excessive regeneration with accumulation of extracellular matrix proteins; it is a precursor of liver cirrhosis and hepatocellular carcinoma. Liver fibrosis treatments are primarily directed at inflammation, with few options to combat fibrogenesis. Pirfenidone is a...

journal_title：Toxicology and applied pharmacology

authors： Seniutkin O,Furuya S,Luo YS,Cichocki JA,Fukushima H,Kato Y,Sugimoto H,Matsumoto T,Uehara T,Rusyn I

更新日期：2018-01-15 00:00:00

abstract：:Diesel exhaust particles (DEPs) cause many adverse health problems, and reports indicate increased risk of breast cancer in men and women through exposure to gasoline and vehicle exhaust. However, DEPs include vast numbers of compounds, and the specific compound(s) responsible for these actions are not clear. We recen...

journal_title：Toxicology and applied pharmacology

authors： Furuta C,Suzuki AK,Watanabe G,Li C,Taneda S,Taya K

更新日期：2008-08-01 00:00:00

abstract：:Therapy of seizure activity following exposure to the nerve agent soman (GD) includes treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of γ-aminobutyric acid A (GABA(A)) receptors. However, seizure activity itself causes the endocytosis of GABA(A) receptors and diminishes the inhibitory effect...

journal_title：Toxicology and applied pharmacology

authors： Schultz MK,Wright LK,Stone MF,Schwartz JE,Kelley NR,Moffett MC,Lee RB,Lumley LA

更新日期：2012-03-15 00:00:00

abstract：:The catalytic activities of glutathione S-transferases (GSTs), particularly the alpha-class isozymes, can provide protection against oxidative stress through GSH-mediated metabolism of reactive products of lipid peroxidation. Lipid peroxidation products from oxidative metabolism in alveolar macrophages play an importa...

journal_title：Toxicology and applied pharmacology

authors： Morrison RJ,Singhal SS,Bidani A,Heming TA,Awasthi S

更新日期：1998-02-01 00:00:00

abstract：:Fumonisins are carcinogenic to rats and are suspected human carcinogens. However, the mechanism(s) of carcinogenesis of fumonisn B1 (FB1) is poorly understood. Multiple signal transduction pathways such as protein kinase C (PKC) have been shown to play an important role in carcinogenesis. This study was undertaken to ...

journal_title：Toxicology and applied pharmacology

authors： Yeung JM,Wang HY,Prelusky DB

更新日期：1996-11-01 00:00:00

abstract：:Investigations have characterized addictive drug-induced developmental cardiovascular malformation in human, non-human primate and rodent. However, the underlying mechanism of malformation caused by drugs during pregnancy is still largely unknown, and preventive and therapeutic measures have been lacking. Using 1H NMR...

journal_title：Toxicology and applied pharmacology

authors： Shao X,Hu Z,Hu C,Bu Q,Yan G,Deng P,Lv L,Wu D,Deng Y,Zhao J,Zhu R,Li Y,Li H,Xu Y,Yang H,Zhao Y,Cen X

更新日期：2012-05-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent hepatocarcinogen in female but not in male rats. In an initiation-promotion model, ovariectomy inhibits TCDD-induced cell replication and reduces both TCDD-induced tumor formation and the promotion of enzyme-altered hepatocellular foci (AHF). The aim of this study...

journal_title：Toxicology and applied pharmacology

authors： Wyde ME,Eldridge SR,Lucier GW,Walker NJ

更新日期：2001-05-15 00:00:00

abstract：:Differential induction of hepatic cytochromes P450 by 3,4,5,3',4'-pentachlorobiphenyl (PENCB) has been observed in the rat and the guinea pig: (1) in rat and guinea pig, treatment with the chosen dose levels resulted in significant induction of total, carbon monoxide-discernible cytochrome P450 content; the absorption...

journal_title：Toxicology and applied pharmacology

authors： Huang S,Gibson GG

更新日期：1991-03-15 00:00:00

abstract：:Heme oxygenase (HO)-1 is an oxidative stress-response enzyme which catalyzes the degradation of heme into bilirubin, ferric ion, and carbon monoxide (CO). Induction of HO-1 was reported to have antitumor activity; the inhibitory mechanism, however, is still unclear. In the present study, we found that treatment with [...

journal_title：Toxicology and applied pharmacology

authors： Lee WY,Chen YC,Shih CM,Lin CM,Cheng CH,Chen KC,Lin CW

更新日期：2014-01-01 00:00:00

abstract：:Selective cyclooxygenase-2 (COX-2) inhibitors have been shown to produce fewer gastrointestinal adverse reactions when compared with conventional nonselective nonsteroidal anti-inflammatory drugs and they suppress angiogenesis in tumors. The purpose of the present study was to investigate the effects of highly selecti...

journal_title：Toxicology and applied pharmacology

authors： Guo JS,Cho CH,Lam Liu ES,Choy HT,Wang JY,Leung Koo MW

更新日期：2002-08-15 00:00:00

abstract：:Arsenic in drinking water is a worldwide health problem that is associated with cardiovascular disease, but the cause is currently unknown. Arsenic effects on platelets, which are important in development of cardiovascular disease, were examined in vitro and in a drinking water study using a rat animal model. Trivalen...

journal_title：Toxicology and applied pharmacology

authors： Lee MY,Bae ON,Chung SM,Kang KT,Lee JY,Chung JH

更新日期：2002-03-01 00:00:00

abstract：:Alcoholic liver disease (ALD) is a major complication of heavy alcohol (EtOH) drinking and is characterized by three progressive stages of pathology: steatosis, steatohepatitis, and fibrosis/cirrhosis. Alcoholic steatosis (AS) is the initial stage of ALD and consists of fat accumulation in the liver accompanied by min...

journal_title：Toxicology and applied pharmacology

authors： Apte UM,Banerjee A,McRee R,Wellberg E,Ramaiah SK

更新日期：2005-08-22 00:00:00

abstract：:Previous studies in this laboratory have shown that the combined exposure of hydrogen chloride (HCI) and formaldehyde vapors (HCHO) elicited a significant incidence of nasal cancer in rats. In studies performed elsewhere, it has been demonstrated that exposure to formaldehyde alone induced a high nasal cancer response...

journal_title：Toxicology and applied pharmacology

authors： Sellakumar AR,Snyder CA,Solomon JJ,Albert RE

更新日期：1985-12-01 00:00:00

abstract：:The embryotoxic and teratogenic potential of inhaled monochlorobenzene (MCB) was evaluated in rats and rabbits. Bred Fischer 344 rats and inseminated New Zealand White rabbits were exposed to 0, 75, 210, or 590 ppm of MCB via inhalation for 6 hr/day during the period of major organogenesis. Exposure to 590 ppm caused ...

journal_title：Toxicology and applied pharmacology

authors： John JA,Hayes WC,Hanley TR Jr,Johnson KA,Gushow TS,Rao KS

更新日期：1984-11-01 00:00:00

abstract：:Cadmium (Cd(2+)) is a widespread environmental pollutant, which is associated with a wide variety of cytotoxic and metabolic effects. Recent studies showed that intoxication with the heavy metal most importantly targets the integrity of the epithelial barrier. In our study, the lung epithelial cell line, NCI H441, was...

journal_title：Toxicology and applied pharmacology

authors： Papritz M,Pohl C,Wübbeke C,Moisch M,Hofmann H,Hermanns MI,Thiermann H,Kirkpatrick CJ,Kehe K

更新日期：2010-06-15 00:00:00

abstract：:Contamination of animal feed with mycotoxins is a major problem for fish feed mainly due to usage of contaminated ingredients for production and inappropriate storage of feed. The use of cereals for fish food production further increases the risk of a potential contamination. Potential contaminants include the mycotox...

journal_title：Toxicology and applied pharmacology

authors： Pietsch C,Bucheli TD,Wettstein FE,Burkhardt-Holm P

更新日期：2011-10-01 00:00:00