Biochemical and functional effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the heart of female rats.

abstract：:The effect of two concentrations of dietary acid (sulfuric acid) or aluminum (aluminum sulfate) on growth and growth-related hormones was examined in a heavy (broiler) strain of chicken between 4 and 18 days old. Growth (body weight, average daily gain, and tibial length) in chicks receiving either dietary acid or alu...

journal_title：Toxicology and applied pharmacology

authors： Capdevielle MC,Scanes CG

更新日期：1995-07-01 00:00:00

abstract：:Cerebellar granule cells are preferentially targeted during methylmercury (MeHg) poisoning. Following acute MeHg exposure, granule cells in culture undergo an increase in intracellular Ca2+ concentration ([Ca2+]i) that apparently contributes to cell death. This effect consists of several temporally and kinetically dis...

journal_title：Toxicology and applied pharmacology

authors： Limke TL,Atchison WD

更新日期：2002-01-01 00:00:00

abstract：:Previous studies in this laboratory have shown that the combined exposure of hydrogen chloride (HCI) and formaldehyde vapors (HCHO) elicited a significant incidence of nasal cancer in rats. In studies performed elsewhere, it has been demonstrated that exposure to formaldehyde alone induced a high nasal cancer response...

journal_title：Toxicology and applied pharmacology

authors： Sellakumar AR,Snyder CA,Solomon JJ,Albert RE

更新日期：1985-12-01 00:00:00

abstract：:Iron tetrakis (N-methyl-4'-pyridyl) porphyrinato (FeTMPyP) has been demonstrated to be a potent scavenger of reactive oxygens and to have antiinflammatory activities. However, the effects of FeTMPyP on the function of T cells have not been illustrated. The objective of this study was to determine whether treatment of ...

journal_title：Toxicology and applied pharmacology

authors： Kang JL,Lee HS,Jung HJ,Kim HJ

更新日期：2003-09-01 00:00:00

abstract：:The M2 subtype of muscarinic receptor is predominant in heart, and such receptors were reported to be located in muscles as well as in presynaptic cholinergic and adrenergic nerve terminals. Muscarinic receptors of rat heart were identified by the high affinity binding of the agonist (+)-[3H]cis-methyldioxolane ([3H]C...

journal_title：Toxicology and applied pharmacology

authors： Silveira CL,Eldefrawi AT,Eldefrawi ME

更新日期：1990-05-01 00:00:00

abstract：:A cadmium-binding substance with a molecular weight even lower than that of metallothionein was demonstrated on Sephadex G-75 gel filtration chromatography of the soluble fractions from newborn human and adult rat liver homogenates and adult human hemolysate which were mixed with CdCl2 in vitro. This substance was pur...

journal_title：Toxicology and applied pharmacology

authors： Katoh M,Mizutani N,Keino H,Kashiwamata S

更新日期：1984-03-30 00:00:00

abstract：:Prescribing appropriate Tacrolimus (Tac) dosing is still a challenge for clinicians due to the interindividual variability in dose requirement and the narrow therapeutic index. Our objective is to identify potential factors that affects Tac exposure in Tunisian Kidney patients and to develop and validate a Tac dose re...

journal_title：Toxicology and applied pharmacology

authors： Ben-Fredj N,Hannachi I,Chadli Z,Ben-Romdhane H,A Boughattas N,Ben-Fadhel N,Aouam K

更新日期：2020-11-15 00:00:00

abstract：:A series of psychopharmacological agents were administered to adult male Fischer-344 rats pretreated with a tremorigenic dose of chlordecone in an attempt to elucidate the involvement of spinal and supraspinal processes in the mediation and/or expression of chlordecone-induced tremor. Agents effective in attenuating t...

journal_title：Toxicology and applied pharmacology

authors： Gerhart JM,Hong JS,Tilson HA

更新日期：1983-09-30 00:00:00

abstract：:Aconitine (AC) is the primary bioactive/toxic alkaloid in plants of the Aconitum species. Our previous study demonstrated that Mdr1 was involved in efflux of AC. However, the mechanism by which Mdr1 regulates the efficacy/toxicity of AC in vivo remains unclear. The present study aimed to determine the effects of Mdr1a...

journal_title：Toxicology and applied pharmacology

authors： Zhu L,Wu J,Zhao M,Song W,Qi X,Wang Y,Lu L,Liu Z

更新日期：2017-04-01 00:00:00

abstract：:Benzene exposure can result in bone marrow myelotoxicity. We examined the effects of benzene metabolites on bone marrow stromal cells of the hemopoietic microenvironment. Male B6C3F1 mouse bone marrow adherent stromal cells were plated at 4 X 10(6) cells per 2 ml of DMEM medium in 35-mm tissue culture dishes. The grow...

journal_title：Toxicology and applied pharmacology

authors： Gaido K,Wierda D

更新日期：1984-10-01 00:00:00

abstract：:It has been proposed [J. D. McKinney, J. Fawkes, S. Jordan, K. Chae, S. Oatley, R. E. Coleman, and W. Briner (1985). Environ. Health Perspect. 61, 41-53] that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces toxic responses through persistent occupancy of nuclear thyroxine (T4) receptors, and that maintenance of re...

journal_title：Toxicology and applied pharmacology

authors： Osborne R,Dold KM,Greenlee WF

更新日期：1987-09-30 00:00:00

abstract：:Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval. However, there is no report showing that this techni...

journal_title：Toxicology and applied pharmacology

authors： Nozaki Y,Honda Y,Tsujimoto S,Watanabe H,Kunimatsu T,Funabashi H

更新日期：2014-07-01 00:00:00

abstract：:Three phenolic glycosides isolated from the heartwood of Pterocarpus marsupium showed significant free radical and superoxide ion scavenging activity and antioxidant potential that were comparable to, or several folds higher than those of standard antioxidants, trolox and ascorbic acid. The effective concentrations of...

journal_title：Toxicology and applied pharmacology

authors： Chakraborty P,Saraswat G,Kabir SN

更新日期：2014-05-15 00:00:00

abstract：:In an earlier study, we exposed nine healthy volunteers to known concentrations of mercury (Hg) vapor in air (median 399; range 365-430 micrograms/m3) for 15 min during light physical exercise (50 W) (Sandborgh-Englund, G., et al., Toxicol. Appl. Pharmacol. 150, 146-153, 1998). Exhaled air, urine, and plasma samples w...

journal_title：Toxicology and applied pharmacology

authors： Jonsson F,Sandborgh-Englund G,Johanson G

更新日期：1999-03-01 00:00:00

abstract：:The elevation of intracellular Ca2+ in various tissue through oxidative stress induced by menadione has been well documented. Increase of Ca2+ level in platelets results in aggregation of platelets. To test the hypothesis that menadione-induced Ca2+ elevations can play a role in platelet aggregation, we have studied t...

journal_title：Toxicology and applied pharmacology

authors： Kim KA,Lee JY,Park KS,Kim MJ,Chung JH

更新日期：1996-05-01 00:00:00

abstract：:The local lymph node assay (LLNA) is a new and promising test in mice used to identify contact allergens by means of dermal exposure. Experimentally this assay, which comprises a sensitizing phase only, is also used to identify respiratory allergens. Another, experimentally used test in mice to identify allergens is a...

journal_title：Toxicology and applied pharmacology

authors： Vandebriel RJ,De Jong WH,Spiekstra SW,Van Dijk M,Fluitman A,Garssen J,Van Loveren H

更新日期：2000-01-15 00:00:00

abstract：:The aim of the present study was to evaluate the in vitro modulation of muscarinic autoreceptor function by the organophosphorus (OP) anticholinesterases chlorpyrifos oxon, paraoxon, and methyl paraoxon. Acetylcholine (ACh) release was studied by preloading slices from rat striatum with [3H]choline and depolarizing wi...

journal_title：Toxicology and applied pharmacology

authors： Liu J,Chakraborti T,Pope C

更新日期：2002-01-15 00:00:00

abstract：:Recent advances have been made in our understanding of the roles played by cutaneous dendritic cells (DCs) in the induction of contact allergy. A number of associated changes in epidermal Langerhans cell phenotype and function required for effective skin sensitization are providing the foundations for the development ...

journal_title：Toxicology and applied pharmacology

authors： Ryan CA,Kimber I,Basketter DA,Pallardy M,Gildea LA,Gerberick GF

更新日期：2007-06-15 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates toxicity of xenobiotics, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Genetic deletion of the AhR leads to cardiac hypertrophy, suggesting a role for the AhR in cardiovascular physiology and disease; however, the pathways invo...

journal_title：Toxicology and applied pharmacology

authors： Lund AK,Goens MB,Kanagy NL,Walker MK

更新日期：2003-12-01 00:00:00

abstract：:Ethylnitrosourea (ENU) is a proven animal teratogen, although the mechanism of its developmental toxicity is unknown. The micromass rat embryo midbrain (CNS) and limb bud (LB) cultures were used in an effort to determine potential mechanisms by which ENU may exert its teratogenic effect. When cultured at high cell den...

journal_title：Toxicology and applied pharmacology

authors： Ribeiro PL,Faustman EM

更新日期：1990-06-15 00:00:00

abstract：:Human exposure to heterocyclic aromatic amines (HAA) usually occurs through mixtures rather than individual compounds. However, the toxic effects and related mechanisms of co-exposure to HAA in humans remain unknown. We compared the effects of two of the most common HAA, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine...

journal_title：Toxicology and applied pharmacology

authors： Dumont J,Jossé R,Lambert C,Anthérieu S,Le Hegarat L,Aninat C,Robin MA,Guguen-Guillouzo C,Guillouzo A

更新日期：2010-06-01 00:00:00

abstract：:1,3-butadiene (BD) has been classified as a human carcinogen, however, the relationship between chromosomal damage and its metabolic polymorphisms is not clear. The present study used the CBMN assay to detect chromosomal damage in the peripheral lymphocytes of 166 exposed workers and 41 non-exposed healthy individuals...

journal_title：Toxicology and applied pharmacology

authors： Tan H,Wang Q,Wang A,Ye Y,Feng N,Feng X,Lu L,Au W,Zheng Y,Xia Z

更新日期：2010-09-15 00:00:00

abstract：:The embryotoxic and teratogenic potential of inhaled monochlorobenzene (MCB) was evaluated in rats and rabbits. Bred Fischer 344 rats and inseminated New Zealand White rabbits were exposed to 0, 75, 210, or 590 ppm of MCB via inhalation for 6 hr/day during the period of major organogenesis. Exposure to 590 ppm caused ...

journal_title：Toxicology and applied pharmacology

authors： John JA,Hayes WC,Hanley TR Jr,Johnson KA,Gushow TS,Rao KS

更新日期：1984-11-01 00:00:00

abstract：:Cyanide intoxication in mice can be antagonized by the local anesthetic, procaine HCI, either alone or in combination with sodium nitrite and/or sodium thiosulfate. Antitoxic potency, derived from LD50 values, was compared in groups of mice pretreated with sodium nitrite (43.9 mg/kg i.p.), sodium thiosulfate (1 g/kg i...

journal_title：Toxicology and applied pharmacology

authors： Jiang S,Liu Z,Zhuang X

更新日期：1998-05-01 00:00:00

abstract：:In this study, we investigated the effect of the aqueous extract of Mosla dianthera (Maxim.) (AEMD) on the mast cell-mediated allergy model and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as asthma, sinusitis and rheumatoid arthritis. The discovery of...

journal_title：Toxicology and applied pharmacology

authors： Lee DH,Kim SH,Eun JS,Shin TY

更新日期：2006-11-01 00:00:00

abstract：:T-2 toxin, a trichothecene mycotoxin, is a potently cytotoxic and immunosuppressive secondary metabolite produced by Fusarium fungi. Young male white Swiss mice were fed a diet supplemented with T-2 toxin at levels of 5, 10, or 20 ppm, control diet ad libitum, or control diet at a restricted rate for 1, 2, 3, 4, and 6...

journal_title：Toxicology and applied pharmacology

authors： Friend SC,Babiuk LA,Schiefer HB

更新日期：1983-06-30 00:00:00

abstract：:The effect of captopril, an angiotensin-converting enzyme inhibitor, on the progression of chronic renal disease was studied in rats subjected to partial nephrectomy. Following ablation of approximately 70% of their renal mass, rats were divided into three treatment groups: group I received a placebo treatment; group ...

journal_title：Toxicology and applied pharmacology

authors： Hall RL,Wilke WL,Fettman MJ

更新日期：1985-09-30 00:00:00

abstract：:Rats were given an ip injection of T-2 mycotoxin (T-2), the T-2 metabolite, T-2 tetraol (tetraol), or cycloheximide. Serum, liver, heart, kidney, spleen, muscle, and intestine were collected at 3, 6, and 9 hr postinjection after a 2-hr pulse at each time with [14C]leucine and [3H]thymidine. Protein and DNA synthesis l...

journal_title：Toxicology and applied pharmacology

authors： Thompson WL,Wannemacher RW Jr

更新日期：1990-09-15 00:00:00

abstract：:Exposure of mice to cationic rhodamines, Rh 123 and Rh 6G, has been found to be associated with developmental toxicity, while neutral rhodamines (e.g., Rh B) had no such effect. When mouse embryos from dams given ip injections of Rh 123, Rh 6G (15 mg/kg), or Rh B (30 mg/kg) on gestation Day (GD) 10 were examined, Rh 1...

journal_title：Toxicology and applied pharmacology

authors： Ranganathan S,Churchill PF,Hood RD

更新日期：1989-06-01 00:00:00

abstract：:In three separate sets of studies, the effects of ureteral ligation and coadministration of cadmium with cysteine or glutathione (GSH) (in either a 4:1 or 2:1 ratio of thiol to cadmium) on the renal disposition of cadmium were assessed in rats 1 h after the administration of cadmium. In all experiments, co-administrat...

journal_title：Toxicology and applied pharmacology

authors： Zalups RK

更新日期：2000-04-01 00:00:00