Dendritic cells and skin sensitization: biological roles and uses in hazard identification.

Abstract:

:Recent advances have been made in our understanding of the roles played by cutaneous dendritic cells (DCs) in the induction of contact allergy. A number of associated changes in epidermal Langerhans cell phenotype and function required for effective skin sensitization are providing the foundations for the development of cellular assays (using DC and DC-like cells) for skin sensitization hazard identification. These alternative approaches to the identification and characterization of skin sensitizing chemicals were the focus of a Workshop entitled "Dendritic Cells and Skin Sensitization: Biological Roles and Uses in Hazard Identification" that was given at the annual Society of Toxicology meeting held March 6-9, 2006 in San Diego, California. This paper reports information that was presented during the Workshop.

journal_name

Toxicol Appl Pharmacol

authors

Ryan CA,Kimber I,Basketter DA,Pallardy M,Gildea LA,Gerberick GF

doi

10.1016/j.taap.2007.03.006

subject

Has Abstract

pub_date

2007-06-15 00:00:00

pages

384-94

issue

3

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(07)00128-7

journal_volume

221

pub_type

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