Abstract：
:The effect of two concentrations of dietary acid (sulfuric acid) or aluminum (aluminum sulfate) on growth and growth-related hormones was examined in a heavy (broiler) strain of chicken between 4 and 18 days old. Growth (body weight, average daily gain, and tibial length) in chicks receiving either dietary acid or aluminum-containing diets were compared to chicks fed a control diet and to chicks fed diets containing sodium sulfate. Despite the reduced growth in acid-fed chicks, there were no changes in the plasma concentrations of growth hormone, insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding proteins (IGF-BP). However, in chicks receiving the high aluminum diet where growth was markedly depressed (by 57%), plasma concentrations of IGF-I were depressed, while those of the 36-kDa IGF-BP were elevated. The effects of acid and aluminum on growth were mediated at least partially by reductions in feed intake. Pair feeding depressed growth and tended to decrease plasma concentrations of IGF-I. Some differences were observed between acid or aluminum groups and their respective pair-fed controls. For the groups receiving the low-aluminum and both the high- and low-acid diets, values were increased compared to corresponding pair-fed controls for average daily gain, the level of the 36-kDa IGF-BP, and skeletal growth. On the other hand, high aluminum had a toxic effect in addition to reducing feed intake, with skeletal growth being reduced more in chicks receiving the aluminum diet than in the pair-fed controls.
journal_name
Toxicol Appl Pharmacoljournal_title
Toxicology and applied pharmacologyauthors
Capdevielle MC,Scanes CGdoi
10.1006/taap.1995.1137subject
Has Abstractpub_date
1995-07-01 00:00:00pages
164-71issue
1eissn
0041-008Xissn
1096-0333pii
S0041-008X(85)71137-4journal_volume
133pub_type
杂志文章abstract：:Reversal of saxitoxin (STX; 10 micrograms/kg, ip) induced cardiorespiratory effects by oxygen ventilation and burro-raised alpha-STX antitoxin (60 mg/kg, i.v.) was studied in urethane-anesthetized guinea pigs acutely instrumented for concurrent monitoring of medullary respiratory-related single units, diaphragm EMG, L...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1006/taap.1994.1006
更新日期：1994-01-01 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/0041-008x(90)90081-5
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1006/taap.1996.0197
更新日期：1996-09-01 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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doi：10.1016/j.taap.2012.04.037
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章,评审
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更新日期：2005-03-15 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1006/taap.1994.1117
更新日期：1994-06-01 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1006/taap.1997.8361
更新日期：1998-04-01 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/j.taap.2010.10.032
更新日期：2011-02-01 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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更新日期：2020-12-15 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章,评审
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更新日期：2011-07-15 00:00:00
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journal_title：Toxicology and applied pharmacology
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doi：10.1016/j.taap.2007.09.008
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/j.taap.2007.05.015
更新日期：2007-09-15 00:00:00
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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更新日期：1999-02-15 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
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更新日期：1989-03-01 00:00:00
abstract：:The mood stabilizing agents lithium chloride (LiCl) and sodium valproate (VPA) have recently gained interest as potential neuroprotective therapeutics. However, exploitation of these therapeutic applications is hindered by both a lack of molecular understanding of the mode of action, and a number of sub-optimal proper...
journal_title：Toxicology and applied pharmacology
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doi：10.1016/j.taap.2008.10.019
更新日期：2009-02-15 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/0041-008x(90)90105-4
更新日期：1990-10-01 00:00:00
abstract：:Carcinogenic chromium (VI) compounds are persistent environmental contaminants with potential for human exposure through drinking water. One lesion associated with chromium (VI) exposure is the formation of DNA-protein crosslinks (DPC). In an attempt to develop markers of chromium exposure, the formation of DPC in lym...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/0041-008x(91)90191-g
更新日期：1991-06-01 00:00:00
abstract：:According to the advocated paradigm shift in toxicology, acquisition of knowledge on the mechanisms underlying the toxicity of chemicals, such as perturbations of biological pathways, is of primary interest. Pluripotent stem cells (PSCs), such as human embryonic stem cells (hESCs) and human induced pluripotent stem ce...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/j.taap.2014.08.007
更新日期：2014-10-15 00:00:00
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journal_title：Toxicology and applied pharmacology
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更新日期：2010-06-01 00:00:00
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journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1006/taap.2000.9067
更新日期：2000-12-01 00:00:00
abstract：:Early-life exposure to arsenic increases risk of developing a variety of non-malignant and malignant diseases. Arsenic-induced carcinogenesis may be mediated through epigenetic mechanisms and pathways leading to inflammation. Our previous study reported that prenatal arsenic exposure leads to increased mRNA expression...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/j.taap.2016.12.015
更新日期：2017-02-01 00:00:00
abstract：:Hepatic systems toxicology is the integrative analysis of toxicogenomic technologies, e.g., transcriptomics, proteomics, and metabolomics, in combination with traditional toxicology measures to improve the understanding of mechanisms of hepatotoxic action. Hepatic toxicology studies that have employed toxicogenomic te...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.taap.2010.10.013
更新日期：2011-01-15 00:00:00
abstract：:Contact sensitization is caused by low molecular weight compounds which penetrate the skin and bind to protein. In many cases, these compounds are activated to reactive species, either by autoxidation on exposure to air or by metabolic activation in the skin. Geraniol, a widely used fragrance chemical, is considered t...
journal_title：Toxicology and applied pharmacology
pub_type： 杂志文章
doi：10.1016/j.taap.2008.08.014
更新日期：2008-12-01 00:00:00
