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The activity of membrane enzymes in homogenate fractions of rat kidney after administration of lead.

Abstract：

:Rats received one or two consecutive daily ip injections, each 0.5 mg Pb2+/100 g body weight, and the kidneys were studied 48 or 24 hr, respectively, after the injection. Renal brush border preparations from Pb2+-treated rats exhibited significant decreases in the activity of alanine aminopeptidase and gamma-glutamyl transpeptidase, greater after two injections, yet the amount of brush border protein remained unchanged. Moreover, the activity of alkaline phosphatase in the brush border was significantly increased after Pb2+. No significant changes in urine volume, urinary protein, or enzymes could be detected in these experiments. The enzymatic changes observed in the brush border after acute exposure to Pb2+ contrasted with those after exposure to Hg2+ where both the structure and enzymatic functions were severely damaged and after exposure to Cd2+ where enzymatic alterations were not accompanied by cytological changes.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Nicholls DM,Teichert-Kuliszewska K,Kuliszewski MJ

doi

10.1016/0041-008x(83)90224-7

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

193-9

issue

2

eissn

0041-008X

issn

1096-0333

journal_volume

67

pub_type

杂志文章

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