当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Effects of lead on the secretion and disappearance of renin in rabbits.

Effects of lead on the secretion and disappearance of renin in rabbits.

Abstract：

:The disappearance rate of renin from plasma was evaluated in both acutely and chronically lead-exposed rabbits. In addition, the effects of lead (Pb) on in vitro renin secretion were determined with rabbit renal cortical slices. Rabbits acutely exposed to Pb (0.3 to 2.0 mg/kg, iv) demonstrated no increase in plasma renin activity (PRA), but a markedly prolonged disappearance of renin following nephrectomy. Together, these observations suggest that renin secretion must have been inhibited; consistent with this hypothesis was the finding that rabbit renal cortical slices exposed to Pb (10(-5) or 10(-6) M) in vitro secreted significantly less renin than did controls. Thus, the effects of large acute doses of Pb in the rabbit are simultaneous inhibition of both renin secretion and clearance. Chronically Pb-exposed rabbits (500 or 1000 ppm in drinking water) had renin half-lives that were not different from controls (6 to 8 min). PRA was also not significantly different in the three groups. Renal slices from both groups of Pb-exposed rabbits secreted significantly more renin in vitro compared to controls, despite the fact that renal renin concentrations were similar in the three groups. However, the responsiveness to a beta adrenergic stimulus was significantly lower in the slices from rabbits treated with 1000 ppm Pb. Taken together these data suggest that PRA in the chronically Pb-exposed rabbit reflects a tendency for increased basal renin secretion, but a counteracting suppression of renin release secondary to adrenergically mediated stimuli; thus, PRA might be reduced, unchanged, or elevated depending upon experimental conditions. Clearance of renin does not seem to be altered in the chronically Pb-exposed rabbit.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Keiser JA,Vander AJ,Germain CL

doi

10.1016/0041-008x(83)90127-8

subject

Has Abstract

pub_date

1983-06-15 00:00:00

pages

117-26

issue

1

eissn

0041-008X

issn

1096-0333

pii

0041-008X(83)90127-8

journal_volume

69

pub_type

杂志文章

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium-metallothionein.

    abstract：:Acute exposure to Cd produces liver injury, whereas chronic exposure results in kidney injury. Tolerance to the hepatotoxicity is observed during chronic exposure to Cd due to the induction of metallothionein (MT). The nephrotoxicity produced by chronic Cd exposure purportedly results from renal uptake of Cd-metalloth...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(88)90231-1

    authors： Sendelbach LE,Klaassen CD

    更新日期：1988-01-01 00:00:00

  • Mercury modulates the cytochrome P450 1a1, 1a2 and 1b1 in C57BL/6J mice: in vivo and in vitro studies.

    abstract：:In the current study C57BL/6J mice were injected intraperitoneally with Hg(2+) in the absence and presence of TCDD. After 6 and 24h the liver was harvested and the expression of Cyps was determined. In vitro, isolated hepatocytes were incubated with TCDD in the presence and absence of Hg(2+). At the in vivo level, Hg(...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.11.027

    authors： Amara IE,Anwar-Mohamed A,Abdelhamid G,El-Kadi AO

    更新日期：2013-02-01 00:00:00

  • Comparison of two routes of chemical administration on the lung adenoma response in strain A/J mice.

    abstract：:This study was undertaken to determine the ability of a series of 19 compounds representing different chemical classes of carcinogens to induce lung tumors in strain A/J mice after either ip or po administration. Aflatoxin B1, dibutylnitrosamine, 1,2-dimethylhydrazine, and methylnitrosourea induced a significant incre...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(86)90433-3

    authors： Stoner GD,Conran PB,Greisiger EA,Stober J,Morgan M,Pereira MA

    更新日期：1986-01-01 00:00:00

  • Nicotine-induced retardation of chondrogenesis through down-regulation of IGF-1 signaling pathway to inhibit matrix synthesis of growth plate chondrocytes in fetal rats.

    abstract：:Previous studies have confirmed that maternal tobacco smoking causes intrauterine growth retardation (IUGR) and skeletal growth retardation. Among a multitude of chemicals associated with cigarette smoking, nicotine is one of the leading candidates for causing low birth weights. However, the possible mechanism of dela...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2013.02.008

    authors： Deng Y,Cao H,Cu F,Xu D,Lei Y,Tan Y,Magdalou J,Wang H,Chen L

    更新日期：2013-05-15 00:00:00

  • Species differences in vacuolation of the choroid plexus induced by the piperidine-ring drug disobutamide in the rat, dog, and monkey.

    abstract：:A subchronic oral toxicity study of disobutamide, a piperidine ring compound with antiarrhythmic activity, was conducted at doses of 30, 100, and 250 mg/kg in rats, 45 mg/kg in dogs, and 90 mg/kg in monkeys. Numerous vacuoles were observed in various organs such as the liver, kidneys, heart, lungs, spleen, thymus, sto...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(86)90421-7

    authors： Koizumi H,Watanabe M,Numata H,Sakai T,Morishita H

    更新日期：1986-06-15 00:00:00

  • 2,2,4-Trimethylpentane-induced nephrotoxicity. I. Metabolic disposition of TMP in male and female Fischer 344 rats.

    abstract：:2,2,4-Trimethylpentane (TMP), a component of unleaded gasoline, causes nephrotoxicity in male, but not in female, rats. In the present study, male and female Fischer 344 rats were treated with a single oral dose of [14C]TMP (4.4 mmol/kg; 2 microCi/mmol). Radiolabeled material in kidney, liver, and plasma was determine...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(87)90098-6

    authors： Charbonneau M,Lock EA,Strasser J,Cox MG,Turner MJ,Bus JS

    更新日期：1987-11-01 00:00:00

  • In vitro effects of benzene metabolites on mouse bone marrow stromal cells.

    abstract：:Benzene exposure can result in bone marrow myelotoxicity. We examined the effects of benzene metabolites on bone marrow stromal cells of the hemopoietic microenvironment. Male B6C3F1 mouse bone marrow adherent stromal cells were plated at 4 X 10(6) cells per 2 ml of DMEM medium in 35-mm tissue culture dishes. The grow...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(84)90027-9

    authors： Gaido K,Wierda D

    更新日期：1984-10-01 00:00:00

  • Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor.

    abstract：:Nitrogen mustard (NM) is a toxic vesicant known to cause damage to the respiratory tract. Injury is associated with increased expression of inducible nitric oxide synthase (iNOS). In these studies we analyzed the effects of transient inhibition of iNOS using aminoguanidine (AG) on NM-induced pulmonary toxicity. Rats w...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.08.027

    authors： Malaviya R,Venosa A,Hall L,Gow AJ,Sinko PJ,Laskin JD,Laskin DL

    更新日期：2012-12-15 00:00:00

  • Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis.

    abstract：:Dietary phytochemicals are excellent ROS-modulating agents and have been shown to effectively enhance ROS levels beyond toxic threshold in cancer cells to ensure their selective killing while leaving normal cells unscathed. Here we demonstrate that hydroxychavicol (HC), extracted and purified from Piper betel leaves, ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.07.012

    authors： Gundala SR,Yang C,Mukkavilli R,Paranjpe R,Brahmbhatt M,Pannu V,Cheng A,Reid MD,Aneja R

    更新日期：2014-10-01 00:00:00

  • Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver.

    abstract：:The farnesoid X receptor (FXR) is a bile acid-activated transcription factor belonging to the nuclear receptor superfamily. FXR deficiency in mice results in cholestasis, metabolic disorders, and tumorigenesis in liver and intestine. FXR is known to contribute to pathogenesis by regulating gene transcription; however,...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.11.012

    authors： Zhu Y,Li G,Dong Y,Zhou HH,Kong B,Aleksunes LM,Richardson JR,Li F,Guo GL

    更新日期：2013-01-15 00:00:00

  • Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells.

    abstract：:The cumulative exposure to estrogens is an important determinant in the risk of breast cancer, yet the full range of mechanisms involving estrogens in the genesis and progression of breast cancer remains a subject of debate. Interactions of estrogens and environmental toxicants have received attention as putative fact...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.07.013

    authors： Spink BC,Bennett JA,Pentecost BT,Lostritto N,Englert NA,Benn GK,Goodenough AK,Turesky RJ,Spink DC

    更新日期：2009-11-01 00:00:00

  • The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK.

    abstract：:CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is the major active agent of the alkaloid derivative of Camptotheca acuminata, with multiple pharmacological activities, including anticancer effects and promotion of apoptosis. The mechanism by which CIL-102 inhibits growth remains poorly understood in hum...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.05.025

    authors： Teng CC,Kuo HC,Cheng HC,Wang TC,Sze CI

    更新日期：2012-08-15 00:00:00

  • Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice.

    abstract：:The skin cancer enhancing effect of chromium (in male mice) and nickel in UVR-irradiated female Skh1 mice was investigated. The dietary vitamin E and selenomethionine were tested for prevention of chromium-enhanced skin carcinogenesis. The mice were exposed to UVR (1.0 kJ/m(2) 3 x weekly) for 26 weeks either alone, or...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.03.030

    authors： Uddin AN,Burns FJ,Rossman TG,Chen H,Kluz T,Costa M

    更新日期：2007-06-15 00:00:00

  • Acrolein generation stimulates hypercontraction in isolated human blood vessels.

    abstract：:Increased risk of vasospasm, a spontaneous hyperconstriction, is associated with atherosclerosis, cigarette smoking, and hypertension-all conditions involving oxidative stress, lipid peroxidation, and inflammation. To test the role of the lipid peroxidation- and inflammation-derived aldehyde, acrolein, in human vasosp...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2006.09.009

    authors： Conklin DJ,Bhatnagar A,Cowley HR,Johnson GH,Wiechmann RJ,Sayre LM,Trent MB,Boor PJ

    更新日期：2006-12-15 00:00:00

  • Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation.

    abstract：:Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval. However, there is no report showing that this techni...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.04.007

    authors： Nozaki Y,Honda Y,Tsujimoto S,Watanabe H,Kunimatsu T,Funabashi H

    更新日期：2014-07-01 00:00:00

  • Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK pathway in human breast cancer MCF-7 cells.

    abstract：:Cadmium (Cd) is a common environmental toxicant and an established carcinogen. Epidemiological studies implicate Cd with human breast cancer. Low micromolar concentrations of Cd promote proliferation of human breast cancer cells in vitro. The growth promotion of breast cancer cells is associated with the activation of...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.05.010

    authors： Song X,Wei Z,Shaikh ZA

    更新日期：2015-08-15 00:00:00

  • Physiologically based pharmacokinetic estimated metabolic constants and hepatotoxicity of carbon tetrachloride after methanol pretreatment in rats.

    abstract：:A single 6-hr exposure to inhaled methanol (MeOH) has been shown to enhance carbon tetrachloride (CCl4) hepatotoxicity. The objective of the present study was to use gas uptake data and the development of a physiologically based pharmacokinetic model (PBPK) to determine in vivo changes in CCl4 metabolism resulting fro...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.0219

    authors： Evans MV,Simmons JE

    更新日期：1996-10-01 00:00:00

  • Platelets and the puzzles of pulmonary pyrrolizidine poisoning.

    abstract：:Pyrrolizidine alkaloids such as monocrotaline (MCT) are toxic plant constituents which poison livestock and humans. Low doses of MCT given to rats result in cardiopulmonary pathophysiologic sequelae similar to forms of chronic pulmonary hypertension in man. This provides a useful model of human disease. The toxicology...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0041-008x(88)90050-6

    authors： Roth RA,Ganey PE

    更新日期：1988-05-01 00:00:00

  • Ghrelin inhibits the apoptosis of MC3T3-E1 cells through ERK and AKT signaling pathway.

    abstract：:Ghrelin is a 28-amino-acid peptide that acts as a natural endogenous ligand of the growth hormone secretagogue receptor (GHSR) and strongly stimulates the release of growth hormone from the hypothalamus-pituitary axis. Previous studies have identified the important physiological effects of ghrelin on bone metabolism, ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2013.07.018

    authors： Liang QH,Liu Y,Wu SS,Cui RR,Yuan LQ,Liao EY

    更新日期：2013-11-01 00:00:00

  • Arsenic, mode of action at biologically plausible low doses: what are the implications for low dose cancer risk?

    abstract：:Arsenic is an established human carcinogen. However, there has been much controversy about the shape of the arsenic response curve, particularly at low doses. This controversy has been exacerbated by the fact that the mechanism(s) of arsenic carcinogenesis are still unclear and because there are few satisfactory anima...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2005.01.048

    authors： Snow ET,Sykora P,Durham TR,Klein CB

    更新日期：2005-09-01 00:00:00

  • Molecular mechanism of teratogenic effects induced by the fungicide triadimefon: study of the expression of TGF-beta mRNA and TGF-beta and CRABPI proteins during rat in vitro development.

    abstract：:Azole derivatives are teratogenic in rats and mice in vitro and in vivo. The postulated mechanism for the dysmorphogenetic effects is the inhibition of retinoic acid (RA)-degrading enzyme CYP26. Azole-related abnormalities are confined to structures controlled by RA, especially the neural crest cells, hindbrain, crani...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.09.025

    authors： Di Renzo F,Corsini E,Broccia ML,Marinovich M,Galli CL,Giavini E,Menegola E

    更新日期：2009-01-01 00:00:00

  • Ferritin and in vivo beryllium toxicity.

    abstract：:Beryllium (Be+2), a divalent metal ion, is toxic to both man and animal. Although the molecular basis for its toxicity is unknown, it is well established that micromolar concentrations of beryllium specifically inhibit certain enzymes. Previous in vitro studies have shown that the presence of ferritin, an iron-storage...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(86)90211-5

    authors： Lindenschmidt RC,Sendelbach LE,Witschi HP,Price DJ,Fleming J,Joshi JG

    更新日期：1986-02-01 00:00:00

  • Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression.

    abstract：:Oxido-inflammatory aberrations play a substantial role in the pathophysiology of depression. Oxido-inflammatory stress increases catabolism of tryptophan into kynurenine which leads to imbalance in kynurenine and serotonin levels in the brain. Naringenin a flavonoid, has been reported to possess antidepressant propert...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2018.07.010

    authors： Bansal Y,Singh R,Saroj P,Sodhi RK,Kuhad A

    更新日期：2018-09-15 00:00:00

  • Chemical reactivity, cytotoxicity, and mutagenicity of chloropropanones.

    abstract：:Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP), and 1,3-dichloropropanone (1,3-DCP). Chloropropanones reacted directly with reduced glutathione (GSH) in sodium phosphate buffer at pH 7.4. All chloropropanones were cytotoxic t...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(87)90192-x

    authors： Merrick BA,Smallwood CL,Meier JR,McKean DL,Kaylor WH,Condie LW

    更新日期：1987-10-01 00:00:00

  • Food ingredient safety evaluation: Utility and relevance of toxicokinetic methods.

    abstract：:The use of toxicokinetic (TK) data is becoming more prevalent in the evaluation of food ingredient safety as more TK information is being incorporated in safety data packages. Data demonstrating "1) the extent of absorption, 2) tissue distribution, 3) pathways and rates of metabolism, and 4) rate(s) of elimination" of...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2019.114759

    authors： Kabadi SV,Zang Y,Fisher JW,Smith N,Whiteside C,Aungst J

    更新日期：2019-11-01 00:00:00

  • The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice.

    abstract：:In a previous study, we demonstrated that parathion suppressed both the primary IgM and IgG response to sheep erythrocytes (SRC) in inbred and outbred mice (G. P. Casale, S. D. Cohen, and R. A. DiCapua, 1982, toxicologist 2, 94). Suppression occurred after a dosage which produced cholinergic effects but was absent aft...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(83)90004-2

    authors： Casale GP,Cohen SD,DiCapua RA

    更新日期：1983-04-01 00:00:00

  • Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice.

    abstract：:Oral administration of dimethylarsinic acid (DMAA), a major metabolite of inorganic arsenics, induces DNA damage in the mouse and rat lung due to both active oxygens and dimethylarsenic peroxyl radical produced in the metabolism of DMAA. Our paper describes the cellular response to DMAA in the mouse lung. In male ICR ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(91)90111-q

    authors： Yamanaka K,Hasegawa A,Sawamura R,Okada S

    更新日期：1991-04-01 00:00:00

  • Analysis of the safety and pharmacodynamics of human fibrinogen concentrate in animals.

    abstract：:Fibrinogen, a soluble 340kDa plasma glycoprotein, is critical in achieving and maintaining hemostasis. Reduced fibrinogen levels are associated with an increased risk of bleeding and recent research has investigated the efficacy of fibrinogen concentrate for controlling perioperative bleeding. European guidelines on t...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.07.019

    authors： Beyerle A,Nolte MW,Solomon C,Herzog E,Dickneite G

    更新日期：2014-10-01 00:00:00

  • miR-181b-5p inhibits endothelial-mesenchymal transition in monocrotaline-induced pulmonary arterial hypertension by targeting endocan and TGFBR1.

    abstract：:Endothelial-mesenchymal transition (EndMT) is a frequent event in endothelial dysfunction, which is associated with pulmonary arterial hypertension (PAH). MiR-181 family members exert diverse effects in multiple biological processes. However, the relationships between miR-181b-5p (miR-181b) and EndMT in PAH are not we...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.114827

    authors： Zhao H,Wang Y,Zhang X,Guo Y,Wang X

    更新日期：2020-01-01 00:00:00

  • In vitro effects of organophosphorus anticholinesterases on muscarinic receptor-mediated inhibition of acetylcholine release in rat striatum.

    abstract：:The aim of the present study was to evaluate the in vitro modulation of muscarinic autoreceptor function by the organophosphorus (OP) anticholinesterases chlorpyrifos oxon, paraoxon, and methyl paraoxon. Acetylcholine (ACh) release was studied by preloading slices from rat striatum with [3H]choline and depolarizing wi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.2001.9326

    authors： Liu J,Chakraborti T,Pope C

    更新日期：2002-01-15 00:00:00