Blood-bound carbon disulfide: an indicator of carbon disulfide exposure, and its accumulation in repeatedly exposed rats.

abstract：:In this study, the effects of pentavalent dimethylarsinic acid ((CH(3))(2)AsO(OH); DMA(V)) and trivalent dimethylarsinous acid ((CH(3))(2)As(OH); DMA(III)) on synaptic transmission generated by the excitatory Schaffer collateral-CA1 synapse were tested in hippocampal slices of young (14-21 day-old) and adult (2-4 mont...

journal_title：Toxicology and applied pharmacology

authors： Krüger K,Repges H,Hippler J,Hartmann LM,Hirner AV,Straub H,Binding N,Musshoff U

更新日期：2007-11-15 00:00:00

abstract：:Calcium uptake in cells occurs through specific membrane channels. Since cadmium and mercury inhibit calcium uptake, this study examined whether the calcium channels may also be involved in the uptake of these metals. Primary cultures of rat hepatocytes were incubated with 3 microM CdCl2 or HgCl2 in the absence or pre...

journal_title：Toxicology and applied pharmacology

authors： Blazka ME,Shaikh ZA

更新日期：1991-09-01 00:00:00

abstract：:The teleost swim bladder is assumed a homolog of the tetrapod lung. Both swim bladder and lung are developmental targets of persistent aryl hydrocarbon receptor (AHR(2)) agonists; in zebrafish (Danio rerio) the swim bladder fails to inflate with exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126). The mechanism for t...

journal_title：Toxicology and applied pharmacology

authors： Jönsson ME,Kubota A,Timme-Laragy AR,Woodin B,Stegeman JJ

更新日期：2012-12-01 00:00:00

abstract：:Although carbon tetrachloride (CCl4) is of concern as a drinking water contaminant, it has been necessary in most oral toxicity studies to give CCl4 in an oil vehicle due to its limited water solubility. The primary objective of our study was to assess the influence of dosing vehicles on the acute hepatotoxicity of CC...

journal_title：Toxicology and applied pharmacology

authors： Kim HJ,Odend'hal S,Bruckner JV

更新日期：1990-01-01 00:00:00

abstract：:The developing neuroendocrine brain represents a potential target for endocrine active chemicals. The UV filter 4-methylbenzylidene camphor (4-MBC) exhibits estrogenic activity, but also interferes with the thyroid axis. We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain...

journal_title：Toxicology and applied pharmacology

authors： Maerkel K,Durrer S,Henseler M,Schlumpf M,Lichtensteiger W

更新日期：2007-01-15 00:00:00

abstract：:Stress response proteins can play integral roles as modulators of cellular function and can be involved in mechanisms that are important to immune function. Metallothionein (MT), a cysteine-rich stress response protein, has been shown to play numerous roles in the cell: it serves as a reservoir of essential heavy meta...

journal_title：Toxicology and applied pharmacology

authors： Crowthers KC,Kline V,Giardina C,Lynes MA

更新日期：2000-08-01 00:00:00

abstract：:Fumonisins are carcinogenic to rats and are suspected human carcinogens. However, the mechanism(s) of carcinogenesis of fumonisn B1 (FB1) is poorly understood. Multiple signal transduction pathways such as protein kinase C (PKC) have been shown to play an important role in carcinogenesis. This study was undertaken to ...

journal_title：Toxicology and applied pharmacology

authors： Yeung JM,Wang HY,Prelusky DB

更新日期：1996-11-01 00:00:00

abstract：:An experimental system was chosen to investigate the bioactivity of a lipoprotein-sequestered toxicant at the cellular level based on recent studies demonstrating receptor-mediated uptake of lipoproteins by macrophages. Rat peritoneal exudate cell suspensions (PEC) were exposed to DDT and lipoprotein-sequestered DDT, ...

journal_title：Toxicology and applied pharmacology

authors： Kaminski NE,Wells DS,Dauterman WC,Roberts JF,Guthrie FE

更新日期：1986-03-15 00:00:00

abstract：:This study sought to investigate the effects of environmentally relevant gestational followed by continued chronic exposure to the herbicide, atrazine, on motor function, cognition, and neurochemical indices of nigrostriatal dopamine (DA) activity in male rats. Dams were treated with 100 μg/kg atrazine, 10mg/kg atrazi...

journal_title：Toxicology and applied pharmacology

authors： Walters JL,Lansdell TA,Lookingland KJ,Baker LE

更新日期：2015-12-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD),12 the most toxic congener of dioxins, exhibits wide sensitivity differences between a sensitive Long-Evans (L-E) rat and a resistant Han/Wistar (H/W) rat. The sensitivity is determined probably by two autosomal genes and it is highly end point dependent. The difference is mo...

journal_title：Toxicology and applied pharmacology

authors： Tuomisto JT,Viluksela M,Pohjanvirta R,Tuomisto J

更新日期：1999-02-15 00:00:00

abstract：:The effect of non-steroidal anti-inflammatory drugs (NSAIDs) on ion channels has been widely studied in several cell models, but less is known about their modulatory mechanisms. In this report, the effect of mefenamic acid on voltage-activated transient outward K(+) current (I(A)) in cultured rat cerebellar granule ce...

journal_title：Toxicology and applied pharmacology

authors： Zhang M,Shi WJ,Fei XW,Liu YR,Zeng XM,Mei YA

更新日期：2008-02-01 00:00:00

abstract：:Male, English smooth haired guinea pigs were exposed to thermal decomposition products, i.e., smoke, generated by heating Douglas fir in an open system. Various amounts of Douglas fir were placed in a furnace, at room temperature, and heated at a rate of 11 degrees C/min until completely decomposed. Major decompositio...

journal_title：Toxicology and applied pharmacology

authors： Wong KL,Stock MF,Malek DE,Alarie Y

更新日期：1984-08-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDI) have been shown to increase differentiation-related gene expression in several tumor-derived cell lines by hyperacetylating core histones. Effects of HDI on primary cultured cells, however, have hardly been investigated. In the present study, the ability of trichostatin A (TSA), a ...

journal_title：Toxicology and applied pharmacology

authors： Henkens T,Papeleu P,Elaut G,Vinken M,Rogiers V,Vanhaecke T

更新日期：2007-01-01 00:00:00

abstract：:Reviewing available data shows that most of antipsychotic drugs are associated with arrhythmia and sudden death. Experimental studies have shown a HERG channel blockade, a dose-dependent increase in duration of action potential or of QT interval, with various degrees of indicators of serious arrhythmogenicity. However...

journal_title：Toxicology and applied pharmacology

authors： Titier K,Canal M,Déridet E,Abouelfath A,Gromb S,Molimard M,Moore N

更新日期：2004-08-15 00:00:00

abstract：:Insulin resistance is a characteristic feature of type 2 diabetes mellitus (T2DM) and is characterized by defects in insulin signaling. Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of the insulin signaling pathways, and its increased activity and expression are implicated in the pathogenesis of ...

journal_title：Toxicology and applied pharmacology

authors： Liu ZQ,Liu T,Chen C,Li MY,Wang ZY,Chen RS,Wei GX,Wang XY,Luo DQ

更新日期：2015-05-15 00:00:00

abstract：:Inorganic arsenic (iAs) is a known toxicant and carcinogen. Worldwide arsenic exposure has become a threat to human health. The severity of arsenic toxicity is strongly correlated with the speed of arsenic metabolism (methylation) and clearance. Furthermore, oxidative stress is recognized as a major mechanism for arse...

journal_title：Toxicology and applied pharmacology

authors： Wang H,Zhu J,Li L,Li Y,Lv H,Xu Y,Sun G,Pi J

更新日期：2017-12-15 00:00:00

abstract：:A pressing need exists to develop and validate molecular biomarkers to assess the early effects of chemical agents, both individually and in mixtures. This is particularly true for new and chemically intensive industries such as the semiconductor industry. Previous studies from this laboratory and others have demonstr...

journal_title：Toxicology and applied pharmacology

authors： Fowler BA,Conner EA,Yamauchi H

更新日期：2005-08-07 00:00:00

abstract：:Using a highly sensitive membrane permeability assay, a viral infection was discovered in the lungs of virus antibody free (VAF) Swiss-Webster mice purchased for respiratory toxicology studies. The assay is based on the uptake of a charged fluorescent compound by cells lacking an intact plasma membrane. Lungs from 74%...

journal_title：Toxicology and applied pharmacology

authors： Phimister AJ,Day KC,Gunderson AD,Wong VJ,Lawson GW,Fanucchi MV,Van Winkle LS,Kendall LV,Plopper CG

更新日期：2003-08-01 00:00:00

abstract：:As an edible traditional Chinese herb, Fructus psoraleae (FP) has been widely used in Asia for the treatment of vitiligo, bone fracture and osteoporosis. Several cases on markedly elevated bilirubin and acute liver injury following administration of FP and its related proprietary medicine have been reported, but the m...

journal_title：Toxicology and applied pharmacology

authors： Wang XX,Lv X,Li SY,Hou J,Ning J,Wang JY,Cao YF,Ge GB,Guo B,Yang L

更新日期：2015-11-15 00:00:00

abstract：:The substrate preference of an aldehyde dehydrogenase induced in rat liver cytosol by 3-methylcholanthrene was examined. This enzyme, T-ALDH, is identical to the aldehyde dehydrogenase inducible in rat liver by 2,3,7,8-tetrachloro-dibenzo-p-dioxin and the tumor-associated aldehyde dehydrogenase found in rat hepatocell...

journal_title：Toxicology and applied pharmacology

authors： Marselos M,Lindahl R

更新日期：1988-09-15 00:00:00

abstract：:Bobwhite quail were exposed to 2,4-dinitrophenol (DNP) in a respirometer designed to continuously monitor exchange of O2 and CO2, from which metabolic rates (MR) were estimated. After 14-16 days of acclimation to the system (temperature 22 degrees C, light cycle 8L:14D), hens received feed amended with 0, 625, or 1250...

journal_title：Toxicology and applied pharmacology

authors： Dominguez SE,Menkel JL,Fairbrother A,Williams BA,Tanner RW

更新日期：1993-12-01 00:00:00

abstract：:The peripherally acting cholinesterase inhibitor pyridostigmine was widely used during the Gulf War as a pretreatment against possible chemical warfare attack. Following consistent reports on long-term illness among Gulf War veterans, pyridostigmine was examined for its possible long-term effects. These effects were s...

journal_title：Toxicology and applied pharmacology

authors： Grauer E,Alkalai D,Kapon J,Cohen G,Raveh L

更新日期：2000-05-01 00:00:00

abstract：:Petroleum-derived compounds, including polycyclic aromatic hydrocarbons (PAHs), commonly occur as complex mixtures in the environment. Recent studies using the zebrafish experimental model have shown that PAHs are toxic to the embryonic cardiovascular system, and that the severity and nature of this developmental card...

journal_title：Toxicology and applied pharmacology

authors： Incardona JP,Linbo TL,Scholz NL

更新日期：2011-12-01 00:00:00

abstract：:Recently, Gray and Ostby (Toxicol. Appl. Pharmacol. 133, 285-294, 1995) reported that in utero and lactational TCDD exposure causes striking abnormalities in the rat female reproductive system, including reduced fecundity and vaginal threads. The mechanism by which TCDD induces such abnormalities is unknown. Thus, we ...

journal_title：Toxicology and applied pharmacology

authors： Flaws JA,Sommer RJ,Silbergeld EK,Peterson RE,Hirshfield AN

更新日期：1997-12-01 00:00:00

abstract：:Patulin is a mycotoxin mainly found in apple and apple products. In addition to being toxic for animals, mutagenic, carcinogenic and teratogenic, patulin induces intestinal injuries, including epithelial cell degeneration, inflammation, ulceration, and hemorrhages. In a study of the cellular mechanisms associated with...

journal_title：Toxicology and applied pharmacology

authors： Mahfoud R,Maresca M,Garmy N,Fantini J

更新日期：2002-06-15 00:00:00

abstract：:Methylmercury (MeHg) causes a multiphasic disruption of intraneuronal cation regulation. Release of Ca2+ from internal stores and entry of extracellular Ca2+ (Ca2+e) contribute to the temporally distinct early (first Ca2+ phase) and late (second Ca2+ phase) components of increased intracellular Ca2+ concentration ([Ca...

journal_title：Toxicology and applied pharmacology

authors： Hare MF,Atchison WD

更新日期：1995-12-01 00:00:00

abstract：:Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke-induced lung injury, we assessed its role in high-level acrolein-induced toxicity in mice. Ac...

journal_title：Toxicology and applied pharmacology

authors： Conklin DJ,Haberzettl P,Jagatheesan G,Kong M,Hoyle GW

更新日期：2017-06-01 00:00:00

abstract：:Arsenic exposure has been shown to exacerbate atherosclerosis, beginning with activation of the endothelium that lines the vessel wall. Endothelial barrier integrity is maintained by proteins of the adherens junction (AJ) such as vascular endothelial cadherin (VE-cadherin) and beta-catenin and their association with t...

journal_title：Toxicology and applied pharmacology

authors： Pereira FE,Coffin JD,Beall HD

更新日期：2007-04-15 00:00:00

abstract：:The effect of two concentrations of dietary acid (sulfuric acid) or aluminum (aluminum sulfate) on growth and growth-related hormones was examined in a heavy (broiler) strain of chicken between 4 and 18 days old. Growth (body weight, average daily gain, and tibial length) in chicks receiving either dietary acid or alu...

journal_title：Toxicology and applied pharmacology

authors： Capdevielle MC,Scanes CG

更新日期：1995-07-01 00:00:00

abstract：:Chronic exposure to low lead concentration produces hypertension; however, the underlying mechanisms remain unclear. We analyzed the role of oxidative stress, cyclooxygenase-2-dependent pathways and MAPK in the vascular alterations induced by chronic lead exposure. Aortas from lead-treated Wistar rats (1st dose: 10 μg...

journal_title：Toxicology and applied pharmacology

authors： Simões MR,Aguado A,Fiorim J,Silveira EA,Azevedo BF,Toscano CM,Zhenyukh O,Briones AM,Alonso MJ,Vassallo DV,Salaices M

更新日期：2015-03-01 00:00:00