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The toxicity of sixteen metallic compounds in Chinese hamster ovary cells.

Abstract：

:The toxicity of 16 metal salts to Chinese hamster ovary (CHO) cells was determined by measuring the cloning efficiency (CE) of CHO cells after exposure to the metals. CHO cells differed by a factor of 10(5) to 10(6) in their toxic response to these metal salts. While Cd(II) was the most toxic ion, Mg(II) exhibited the least toxicity based on either CE50 (concentration required to reduce the CE to 50%) or D0 (concentration increment which reduced the CE by 63%). On the basis of CE50, the toxicity ranking was Ag greater than Tl for monovalent metals, Cd greater than Zn greater than Hg greater than Co greater Cu greater than Mn greater than Ni greater than Be greater than Pd greater than Sr greater than Mg for divalent metals, and In greater than Rh greater than Y for trivalent metals. A similar ranking was found for D0. For the 11 divalent metals, correlations of CE50 and D0 in the CHO cell assay and the Pearson-Mawby softness parameter for metals (sigma p) were reasonably strong. A good correlation exists between the results of this study on the toxic response in CHO cells and published data on toxicity in mice and Drosophila. It appears that the CHO cell cloning assay may be useful in preliminary screening of metallic compounds as an indicator of their predicted toxicity in higher organisms.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Tan EL,Williams MW,Schenley RL,Perdue SW,Hayden TL,Turner JE,Hsie AW

doi

10.1016/0041-008x(84)90286-2

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

330-6

issue

3

eissn

0041-008X

issn

1096-0333

journal_volume

74

pub_type

杂志文章

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