Liposomal formulation of alpha-tocopheryl maleamide: in vitro and in vivo toxicological profile and anticancer effect against spontaneous breast carcinomas in mice.

abstract：:Inflammatory responses are accompanied by increased expression of hepatocyte-derived proteins collectively known as acute phase reactants (APR). B6C3F1 female mice were exposed intraperitoneally every 24 hr to either vehicle (PBS) or DMN (5 mg/kg) for up to six exposures. Following a single treatment (acute), liver ti...

journal_title：Toxicology and applied pharmacology

authors： Lockwood JF,Rutherford MS,Myers MJ,Schook LB

更新日期：1994-04-01 00:00:00

abstract：:Nitrogen mustard is a vesicant that causes damage to the respiratory tract. In these studies, we characterized the acute effects of nitrogen mustard on lung structure, inflammatory mediator expression, and pulmonary function, with the goal of identifying mediators potentially involved in toxicity. Treatment of rats (m...

journal_title：Toxicology and applied pharmacology

authors： Sunil VR,Patel KJ,Shen J,Reimer D,Gow AJ,Laskin JD,Laskin DL

更新日期：2011-01-01 00:00:00

abstract：:The mechanism underlying glaucoma remains controversial, but apoptosis caused by increased levels of reactive oxygen species (ROS) is thought to play a role in its pathogenesis. We investigated the effects of compounds isolated from Psoralea corylifolia on oxidative stress-induced cell death in vitro and in vivo. Tran...

journal_title：Toxicology and applied pharmacology

authors： Kim KA,Shim SH,Ahn HR,Jung SH

更新日期：2013-06-01 00:00:00

abstract：:Pretreatment of rats with the polychlorinated biphenyl (PCB) Aroclor 1254 or phenobarbital markedly increased the duodenal ulcerogenic action of acrylonitrile. The extent of forestomach and hepatic lesions in these rats, on the other hand, was not modified. The duodenal ulcers produced by Aroclor 1254 and acrylonitril...

journal_title：Toxicology and applied pharmacology

authors： Szabo S,Silver EH,Gallagher GT,Maull EA

更新日期：1983-12-01 00:00:00

abstract：:Glucocorticoid Receptor (GR) is present in virtually every human cell type. Representing a nuclear receptor superfamily, GR has several different isoforms essentially acting as ligand-dependent transcription factors, regulating glucocorticoid-responsive gene expression in both a positive and a negative manner. Althoug...

journal_title：Toxicology and applied pharmacology

authors： Gulliver LS

更新日期：2017-03-15 00:00:00

abstract：:Mitotic catastrophe, a form of cell death resulting from abnormal mitosis, is a cytotoxic death pathway as well as an appealing mechanistic strategy for the development of anti-cancer drugs. In this study, 6-bromine-5-hydroxy-4-methoxybenzaldehyde was demonstrated to induce DNA double-strand break, multipolar spindles...

journal_title：Toxicology and applied pharmacology

authors： Zhang B,Huang B,Guan H,Zhang SM,Xu QZ,He XP,Liu XD,Wang Y,Shang ZF,Zhou PK

更新日期：2011-05-01 00:00:00

abstract：:Ethanol induces cumulative liver damage including steatosis, steatohepatitis and cirrhosis. The aim of this study is to investigate the global intrahepatic gene expression profile in the mouse liver treated with ethanol. A single oral dose of 0.5 or 5 g/kg ethanol was administered to male ICR mice, and liver samples w...

journal_title：Toxicology and applied pharmacology

authors： Yin HQ,Kim M,Kim JH,Kong G,Kang KS,Kim HL,Yoon BI,Lee MO,Lee BH

更新日期：2007-09-15 00:00:00

abstract：:Follicle growth culminates in ovulation, which allows for the expulsion of fertilizable oocytes and the formation of corpora lutea. Bisphenol A (BPA) is present in many consumer products, and it has been suggested that BPA impairs ovulation; however, the underlying mechanisms are unknown. Therefore, this study first e...

journal_title：Toxicology and applied pharmacology

authors： Moore-Ambriz TR,Acuña-Hernández DG,Ramos-Robles B,Sánchez-Gutiérrez M,Santacruz-Márquez R,Sierra-Santoyo A,Piña-Guzmán B,Shibayama M,Hernández-Ochoa I

更新日期：2015-12-15 00:00:00

abstract：:In a previous study, we demonstrated that parathion suppressed both the primary IgM and IgG response to sheep erythrocytes (SRC) in inbred and outbred mice (G. P. Casale, S. D. Cohen, and R. A. DiCapua, 1982, toxicologist 2, 94). Suppression occurred after a dosage which produced cholinergic effects but was absent aft...

journal_title：Toxicology and applied pharmacology

authors： Casale GP,Cohen SD,DiCapua RA

更新日期：1983-04-01 00:00:00

abstract：:Methemoglobin formation, as well as hemoglobin or DNA adducts, are useful biomarkers of occupational exposure to certain arylamines. It has been suggested that, in liver from animals not treated with a cytochrome P450 (CYP) inducer, hepatic CYP1A2 is the major P450 involved in N-hydroxylation. This is the first step i...

journal_title：Toxicology and applied pharmacology

authors： Shertzer HG,Dalton TP,Talaska G,Nebert DW

更新日期：2002-05-15 00:00:00

abstract：:Homocysteine is increased during pathological conditions, endangering vascular and cognitive functions, and elevated homocysteine during pregnancy may be correlated with an increased incidence of schizophrenia in the offspring. This study showed that millimolar homocysteine concentrations in saline medium cause phosph...

journal_title：Toxicology and applied pharmacology

authors： Gu L,Hu X,Xue Z,Yang J,Wan L,Ren Y,Hertz L,Peng L

更新日期：2010-01-15 00:00:00

abstract：:Intracellular retention of toxic bile salts contributes to hepatocellular injury during cholestasis. We have recently demonstrated that toxic bile salts directly induce apoptosis in hepatocytes. As oxidative stress has been implicated in many models of apoptosis, our aim was to determine if oxidative injury is a criti...

journal_title：Toxicology and applied pharmacology

authors： Patel T,Gores GJ

更新日期：1997-01-01 00:00:00

abstract：:To characterize modes of action of substances and their cytotoxic effects Bionas GmbH has developed a new screening system to allow the continuous recording of how an active substance can act (Bionas 2500 analyzing system). In the pharmaceutical industry it is important to acquire as much information as possible about...

journal_title：Toxicology and applied pharmacology

authors： Thedinga E,Kob A,Holst H,Keuer A,Drechsler S,Niendorf R,Baumann W,Freund I,Lehmann M,Ehret R

更新日期：2007-04-01 00:00:00

abstract：:Contamination of animal feed with mycotoxins is a major problem for fish feed mainly due to usage of contaminated ingredients for production and inappropriate storage of feed. The use of cereals for fish food production further increases the risk of a potential contamination. Potential contaminants include the mycotox...

journal_title：Toxicology and applied pharmacology

authors： Pietsch C,Bucheli TD,Wettstein FE,Burkhardt-Holm P

更新日期：2011-10-01 00:00:00

abstract：:Previous experiments showed that treatment of mice and rats with thioacetamide (TAA) induced liver cell damage, fibrosis and/or cirrhosis, associated with increased oxidative stress and activation of hepatic stellate cells. Some experiments suggest that CYP2E1 may be involved in the metabolic activation of TAA. Howeve...

journal_title：Toxicology and applied pharmacology

authors： Kang JS,Wanibuchi H,Morimura K,Wongpoomchai R,Chusiri Y,Gonzalez FJ,Fukushima S

更新日期：2008-05-01 00:00:00

abstract：:The high affinity metal-binding protein metallothionein (MT) is thought to detoxify cadmium (Cd) but appears to be deficient in several known targets of Cd carcinogenesis. The rat ventral prostate (VP) was recently identified as one of these target tissues. The nature of the Cd-binding proteins in the prostate has not...

journal_title：Toxicology and applied pharmacology

authors： Waalkes MP,Perantoni A

更新日期：1989-10-01 00:00:00

abstract：:Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. New BPD is characterized as having alveolar simplification. We reported previously that aryl hydrocarbon receptor (AhR) deficiency increased susceptibility to hyperoxic lung injury in adult mice, and this was associated ...

journal_title：Toxicology and applied pharmacology

authors： Shivanna B,Zhang W,Jiang W,Welty SE,Couroucli XI,Wang L,Moorthy B

更新日期：2013-03-15 00:00:00

abstract：:Chronic arsenic exposure through contaminated drinking water is a major environmental health issue. Chronic arsenic exposure is known to exert its toxic effects by a variety of mechanisms, of which generation of reactive oxygen species (ROS) is one of the most important. A high level of ROS, in turn, leads to DNA dama...

journal_title：Toxicology and applied pharmacology

authors： Banerjee M,Banerjee N,Ghosh P,Das JK,Basu S,Sarkar AK,States JC,Giri AK

更新日期：2010-11-15 00:00:00

abstract：:Tissue concentrations of mercury were determined by cold vapor atomic absorption spectrometry in different inbred mouse strains after continuous treatment with HgCl2 (3 weekly sc injections of 0.5 mg/kg bw) for up to 12 weeks. Except for the thymus, in which steadily increasing mercury concentrations were found, in st...

journal_title：Toxicology and applied pharmacology

authors： Griem P,Scholz E,Turfeld M,Zander D,Wiesner U,Dunemann L,Gleichmann E

更新日期：1997-05-01 00:00:00

abstract：:The aims of this study were to investigate whether several histamine receptor agonists and antagonists are subjected to receptor-independent ion trapping into acidic organelles, and whether this sequestration influences their pharmacological or toxicological properties. Vacuolar (V)-ATPase-dependent intracellular sequ...

journal_title：Toxicology and applied pharmacology

authors： Morissette G,Lodge R,Bouthillier J,Marceau F

更新日期：2008-06-15 00:00:00

abstract：:Information presented at this symposium indicates that modulation of Th cell responses is one means by which xenobiotics may cause immunotoxicity. A shift from Th1 to Th2 responses can enhance both infectious and allergic disease. Hence, in some cases, a common mechanism may be responsible for effects that are general...

journal_title：Toxicology and applied pharmacology

authors： Selgrade MK,Lawrence DA,Ullrich SE,Gilmour MI,Schuyler MR,Kimber I

更新日期：1997-07-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) is a critical stage during the development of silicosis fibrosis. In the current study, we hypothesized that the anti-fibrotic tetrapeptide, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) may exert its anti-fibrotic effects via activation of the TGF-β1/ROCK1 pathway, leadin...

journal_title：Toxicology and applied pharmacology

authors： Deng H,Xu H,Zhang X,Sun Y,Wang R,Brann D,Yang F

更新日期：2016-03-01 00:00:00

abstract：:Earlier, we reported that chronic cadmium (Cd)-exposure to prostate epithelial (RWPE-1) cells causes defective autophagy, which leads to the transformation of a malignant phenotype in both in vitro and in vivo models. However, the upstream events responsible for defective autophagy are yet to be delineated. The presen...

journal_title：Toxicology and applied pharmacology

authors： Kolluru V,Tyagi A,Chandrasekaran B,Ankem M,Damodaran C

更新日期：2019-06-15 00:00:00

abstract：:Mycotoxin citrinin (CTN) is commonly found in foods and feeds that are contaminated/inoculated with Penicillium, Aspergillus and Monascus species. The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein ki...

journal_title：Toxicology and applied pharmacology

authors： Chang CH,Yu FY,Wang LT,Lin YS,Liu BH

更新日期：2009-06-15 00:00:00

abstract：:Male Wistar rats pretreated with ethanol (2.0 g in 80 ml liquid diet/day for 3 weeks) or phenobarbital (PB, 80 mg/kg/day ip for 4 days) were exposed by inhalation to 500, 1000, 2000, 4000, or 8000 ppm trichloroethylene (TRI) for 2 or 8 hr, and the blood concentration of TRI and the urinary concentration of TRI metabol...

journal_title：Toxicology and applied pharmacology

authors： Nakajima T,Okino T,Okuyama S,Kaneko T,Yonekura I,Sato A

更新日期：1988-06-30 00:00:00

abstract：:Azole derivatives are teratogenic in rats and mice in vitro and in vivo. The postulated mechanism for the dysmorphogenetic effects is the inhibition of retinoic acid (RA)-degrading enzyme CYP26. Azole-related abnormalities are confined to structures controlled by RA, especially the neural crest cells, hindbrain, crani...

journal_title：Toxicology and applied pharmacology

authors： Di Renzo F,Corsini E,Broccia ML,Marinovich M,Galli CL,Giavini E,Menegola E

更新日期：2009-01-01 00:00:00

abstract：:The multidrug resistance (MDR) transporter is a phosphorylated glycoprotein (P-gp) that has been implicated in the efflux of a large variety of xenobiotics, thereby protecting vital organs. This study examines the hypothesis that the multidrug resistance transporter is involved in restricting the entry of polychlorina...

journal_title：Toxicology and applied pharmacology

authors： Tampal NM,Robertson LW,Srinivasan C,Ludewig G

更新日期：2003-03-15 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants and many of their toxic effects, including their immunotoxicities, are mediated by the activation of aryl hydrocarbon receptor (AhR). We previously reported that Aroclor 1254, one of the most widely used PCB mixtures, increased DNA fragmentatio...

journal_title：Toxicology and applied pharmacology

authors： Jeon YJ,Youk ES,Lee SH,Suh J,Na YJ,Kim HM

更新日期：2002-06-01 00:00:00

abstract：:The sensory irritation potential of a series of saturated and unsaturated aliphatic and cyclic aldehydes was investigated in B6C3F1 and Swiss-Webster mice. With the reflex decrease in respiratory rate as the endpoint response, alpha, beta-unsaturated aliphatic aldehydes yielded RD50 values (concentration which elicits...

journal_title：Toxicology and applied pharmacology

authors： Steinhagen WH,Barrow CS

更新日期：1984-03-15 00:00:00

abstract：:It has been known for many years that administration of androgens or estrogens at critical periods of development in mammals causes severe long-term effects on the endocrine/genital systems. The environmental pollutant p-tert-octylphenol (OP) possesses a weak but clear estrogen agonist activity in in vitro and in vivo...

journal_title：Toxicology and applied pharmacology

authors： Katsuda S,Yoshida M,Watanabe G,Taya K,Maekawa A

更新日期：2000-06-15 00:00:00