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Modulation of T-helper cell populations: potential mechanisms of respiratory hypersensitivity and immune suppression.

Abstract：

:Information presented at this symposium indicates that modulation of Th cell responses is one means by which xenobiotics may cause immunotoxicity. A shift from Th1 to Th2 responses can enhance both infectious and allergic disease. Hence, in some cases, a common mechanism may be responsible for effects that are generally considered to be very different. Because cytokines produced in the inflammatory process play a role in modulation of Th cell responses, there is a mechanism by which agents that appear to have only local effects at the portal of entry may, in fact, affect immune responses systemically. An understanding of conditions which trigger certain cytokine responses may be useful not only in understanding inflammation but also in predicting certain kinds of immunosuppressive and allergic responses. Future studies in this area are likely to provide insights into many areas of immunotoxicology.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Selgrade MK,Lawrence DA,Ullrich SE,Gilmour MI,Schuyler MR,Kimber I

doi

10.1006/taap.1997.8142

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

218-29

issue

1

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(97)98142-4

journal_volume

145

pub_type

杂志文章,评审

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