当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Ethanol-induced enhancement of trichloroethylene metabolism and hepatotoxicity: difference from the effect of phenobarbital.

Ethanol-induced enhancement of trichloroethylene metabolism and hepatotoxicity: difference from the effect of phenobarbital.

Abstract：

:Male Wistar rats pretreated with ethanol (2.0 g in 80 ml liquid diet/day for 3 weeks) or phenobarbital (PB, 80 mg/kg/day ip for 4 days) were exposed by inhalation to 500, 1000, 2000, 4000, or 8000 ppm trichloroethylene (TRI) for 2 or 8 hr, and the blood concentration of TRI and the urinary concentration of TRI metabolites (trichloroethanol (TCE) and trichloroacetic acid (TCA] were determined at various times. Plasma glutamic-pyruvic transaminase (GPT) activity was measured 22 hr after the end of exposure as an indicator of hepatic damage. Both ethanol and PB enhanced TRI metabolism as evidenced by accelerated disappearance of TRI from the blood and increased excretion of total trichloro compounds (TCE + TCA) in the urine. However, the effects of ethanol and PB were different from each other: ethanol markedly enhanced the metabolism particularly at TRI concentration of 2000 ppm or lower, whereas PB enhanced it only at 4000 ppm or higher. This difference was also reflected in the effect of TRI on liver: ethanol potentiated TRI hepatotoxicity more markedly than did PB when TRI concentration remained 2000 ppm or lower, whereas PB potentiated the toxicity more markedly than ethanol when the concentration was 4000 ppm or higher. It is noteworthy that ethanol potentiated TRI hepatotoxicity at a TRI concentration as low as 500 ppm. The severity of hepatic damage expressed by plasma GPT activity essentially paralleled the urinary excretion rate of total trichloro compounds during and 4 hr after exposure (r = 0.87 to 0.93). Compared between the contribution of concentration and duration of exposure to the toxicity, a higher concentration of TRI tended to cause more severe liver damage to PB-treated rats than did a prolonged period of exposure, whereas the toxicity in ethanol-treated rats was generally more marked in rats exposed to TRI for a longer period than in rats exposed to a higher concentration.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Nakajima T,Okino T,Okuyama S,Kaneko T,Yonekura I,Sato A

doi

10.1016/0041-008x(88)90264-5

subject

Has Abstract

pub_date

1988-06-30 00:00:00

pages

227-37

issue

eissn

0041-008X

issn

1096-0333

pii

0041-008X(88)90264-5

journal_volume

pub_type

杂志文章

在线工具

Ethanol-induced enhancement of trichloroethylene metabolism and hepatotoxicity: difference from the effect of phenobarbital.