Leveraging microbial biosynthetic pathways for the generation of 'drop-in' biofuels.

Abstract:

:Advances in retooling microorganisms have enabled bioproduction of 'drop-in' biofuels, fuels that are compatible with existing spark-ignition, compression-ignition, and gas-turbine engines. As the majority of petroleum consumption in the United States consists of gasoline (47%), diesel fuel and heating oil (21%), and jet fuel (8%), 'drop-in' biofuels that replace these petrochemical sources are particularly attractive. In this review, we discuss the application of aldehyde decarbonylases to produce gasoline substitutes from fatty acid products, a recently crystallized reductase that could hydrogenate jet fuel precursors from terpene synthases, and the exquisite control of polyketide synthases to produce biofuels with desired physical properties (e.g., lower freezing points). With our increased understanding of biosynthetic logic of metabolic pathways, we discuss the unique advantages of fatty acid, terpene, and polyketide synthases for the production of bio-based gasoline, diesel and jet fuel.

journal_name

Curr Opin Biotechnol

authors

Zargar A,Bailey CB,Haushalter RW,Eiben CB,Katz L,Keasling JD

doi

10.1016/j.copbio.2017.03.004

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

156-163

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(16)30190-2

journal_volume

45

pub_type

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