Abstract:
OBJECTIVE:The prognosis of patients with locally advanced squamous cell carcinoma (SCC) of the tongue is poor. Postoperative chemoradiotherapy (CRT) improves locoregional control and survival in high-risk patients. We investigated the prognostic factors for clinical T4a tongue SCC, and elucidated whether postoperative CRT has a benefit for patients with poor prognosis in terms of survival. METHODS:We performed a retrospective analysis of 61 patients with stage T4a SCC of the tongue who underwent primary resection and neck dissection. RESULTS:The median follow-up was 53.8 months. Multivariate analysis revealed a 4.26× relative risk of death for patients with the involvement of ≥5 regional lymph nodes (pN ≥5) compared with those with pN 0-4 (p = 0.002). In Kaplan-Meier analysis, patients with pN ≥5 who received CRT had longer overall survival rates than those who did not (hazard ratio = 0.31; p = 0.041). CONCLUSIONS:pN ≥5 is the most powerful prognostic factor for clinical T4a SCC of the tongue. Postoperative CRT is recommended in patients with pN ≥5.
journal_name
Oncologyjournal_title
Oncologyauthors
Yokota T,Iida Y,Ogawa H,Kamijo T,Onozawa Y,Todaka A,Hamauchi S,Onoe T,Nakagawa M,Yurikusa T,Tanuma A,Yamashita A,Nishimura T,Yasui H,Onitsuka Tdoi
10.1159/000446439subject
Has Abstractpub_date
2016-01-01 00:00:00pages
78-84issue
2eissn
0030-2414issn
1423-0232pii
000446439journal_volume
91pub_type
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