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Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.

Abstract：

:We report here the generation of human iPS cell line UKKi009-A from dermal fibroblasts of a patient carrying heterozygous mutation c.3035-3045delTCCCTCGATGC, p.Leu1012Pro (fs*55) in KCNH2 gene leading to long QT syndrome type 2 (LQT2). We used the Sleeping Beauty transposon-based plasmids expressing OSKM along with microRNAs 307/367 to reprogram the fibroblasts. The iPS cells possess pluripotent stem cell characteristics and differentiate to cell lineages of all three germ layers. This cell line can serve as a source for in vitro modeling of LQT2. This cell line is distributed by the European Collection of Authenticated Cell Cultures (ECACC).

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Fatima A,Ivanyuk D,Herms S,Heilmann-Heimbach S,O'Shea O,Chapman C,Izsvák Z,Farr M,Hescheler J,Šarić T

doi

10.1016/j.scr.2015.12.039

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

304-7

issue

2

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(16)00003-9

journal_volume

16

pub_type

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