High-performance liquid chromatographic separation of enantiomeric alkyl glycerol ethers.

Abstract:

:The resolution of a series of racemic 1-alkyl-3-trityl-rac-glycerols and 1-alkyl-2-benzyl-rac-glycerols into their enantiomers by high-performance liquid chromatography (HPLC) was investigated. Of the racemic glycerol derivatives studied, only three (1,2-0-isopropylidene-rac-glycerol, 1,2-0-isopropylidene-3-benzyl-rac-glycerol and 1-hexadecyl-2-benzyl-rac-glycerol) could be resolved into their enantiomers. The compounds were resolved on a silica (10 μm) column coated with cellulose tribenzoate and eluted isocratically with hexane/isopropanol as mobile phase. The effects of mobile phase composition, column temperature and flow rate on the resolution of enantiomeric pairs were investigated. Also, the effect of substituents,i.e., trityl, benzyl, hydroxyl or alkyl, on the resolution of the alkyl glycerol ethers by HPLC was evaluated.

journal_name

Lipids

journal_title

Lipids

authors

Foglia TA,Maeda K

doi

10.1007/BF02535629

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

769-73

issue

9

eissn

0024-4201

issn

1558-9307

pii

10.1007/BF02535629

journal_volume

26

pub_type

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