Abstract:
:The resolution of a series of racemic 1-alkyl-3-trityl-rac-glycerols and 1-alkyl-2-benzyl-rac-glycerols into their enantiomers by high-performance liquid chromatography (HPLC) was investigated. Of the racemic glycerol derivatives studied, only three (1,2-0-isopropylidene-rac-glycerol, 1,2-0-isopropylidene-3-benzyl-rac-glycerol and 1-hexadecyl-2-benzyl-rac-glycerol) could be resolved into their enantiomers. The compounds were resolved on a silica (10 μm) column coated with cellulose tribenzoate and eluted isocratically with hexane/isopropanol as mobile phase. The effects of mobile phase composition, column temperature and flow rate on the resolution of enantiomeric pairs were investigated. Also, the effect of substituents,i.e., trityl, benzyl, hydroxyl or alkyl, on the resolution of the alkyl glycerol ethers by HPLC was evaluated.
journal_name
Lipidsjournal_title
Lipidsauthors
Foglia TA,Maeda Kdoi
10.1007/BF02535629subject
Has Abstractpub_date
1991-09-01 00:00:00pages
769-73issue
9eissn
0024-4201issn
1558-9307pii
10.1007/BF02535629journal_volume
26pub_type
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