Origin and quantification of differences between normal and tumor tissues observed by terahertz spectroscopy.

Abstract:

:The origin of the differences in the refractive index observed between normal and tumor tissues using terahertz spectroscopy has been described quantitatively. To estimate water content differences in tissues, we prepared fresh and paraffin-embedded samples from rats. An approximately 5% increase of water content in tumor tissues was calculated from terahertz time domain spectroscopy measurements compared to normal tissues. A greater than 15% increase in percentage of cell nuclei per unit area in tumor tissues was observed by hematoxylin and eosin stained samples, which generates a higher refractive index of biological components other than water. Both high water content and high cell density resulted in higher refractive index by approximately 0.05 in tumor tissues. It is predicted that terahertz spectroscopy can also be used to detect brain tumors in human tissue due to the same underlying mechanism as in rats.

journal_name

Phys Med Biol

authors

Yamaguchi S,Fukushi Y,Kubota O,Itsuji T,Ouchi T,Yamamoto S

doi

10.1088/0031-9155/61/18/6808

subject

Has Abstract

pub_date

2016-09-21 00:00:00

pages

6808-6820

issue

18

eissn

0031-9155

issn

1361-6560

journal_volume

61

pub_type

杂志文章
  • Application of the adaptive wavelet transform for analysis of blood flow oscillations in the human skin.

    abstract::An original method for the analysis of oscillations of cutaneous blood flow has been developed, which makes use of laser Doppler flowmetry (LDF) data and is based on the continuous wavelet transform and adaptive wavelet theory. The potential of the method has been demonstrated in experiments with the response of micro...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/21/005

    authors: Tankanag A,Chemeris N

    更新日期:2008-11-07 00:00:00

  • Effect of inter-crystal scatter on estimation methods for random coincidences and subsequent correction.

    abstract::Random coincidences can contribute substantially to the background in positron emission tomography (PET). Several estimation methods are being used for correcting them. The goal of this study was to investigate the validity of techniques for random coincidence estimation, with various low-energy thresholds (LETs). Sim...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/9/012

    authors: Torres-Espallardo I,Rafecas M,Spanoudaki V,McElroy DP,Ziegler SI

    更新日期:2008-05-07 00:00:00

  • Analytic treatment of resolution precision in electronically collimated SPECT imaging involving multiple-interaction gamma rays.

    abstract::The widely applied single-interaction analytic expression characterizing the energy resolution component of the angular resolution precision for an electronically collimated point source is extended to include multiple-interaction Compton scatter sequences as well as sequences terminated by photoelectric absorption. T...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/10/021

    authors: Durkee JW Jr,Antich PP,Tsyganov EN,Constantinescu A,Kulkarni PV,Smith BJ,Arbique GM,Lewis MA,Nguyen T,Raheja A,Thambi G,Parkey RW

    更新日期:1998-10-01 00:00:00

  • The fast Padé transform in magnetic resonance spectroscopy for potential improvements in early cancer diagnostics.

    abstract::The convergence rates of the fast Padé transform (FPT) and the fast Fourier transform (FFT) are compared. These two estimators are used to process a time-signal encoded at 4 T by means of one-dimensional magnetic resonance spectroscopy (MRS) for healthy human brain. It is found systematically that at any level of trun...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/18/010

    authors: Belkić D,Belkić K

    更新日期:2005-09-21 00:00:00

  • Imaging of prompt gamma rays emitted during delivery of clinical proton beams with a Compton camera: feasibility studies for range verification.

    abstract::The purpose of this paper is to evaluate the ability of a prototype Compton camera (CC) to measure prompt gamma rays (PG) emitted during delivery of clinical proton pencil beams for prompt gamma imaging (PGI) as a means of providing in vivo verification of the delivered proton radiotherapy beams. A water phantom was i...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/18/7085

    authors: Polf JC,Avery S,Mackin DS,Beddar S

    更新日期:2015-09-21 00:00:00

  • Implementation of tetrahedral-mesh geometry in Monte Carlo radiation transport code PHITS.

    abstract::A new function to treat tetrahedral-mesh geometry was implemented in the particle and heavy ion transport code systems. To accelerate the computational speed in the transport process, an original algorithm was introduced to initially prepare decomposition maps for the container box of the tetrahedral-mesh geometry. Th...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa6b45

    authors: Furuta T,Sato T,Han MC,Yeom YS,Kim CH,Brown JL,Bolch WE

    更新日期:2017-06-21 00:00:00

  • Beam characterisation of the 1.5 T MRI-linac.

    abstract::As a prerequisite for clinical treatments it was necessary to characterize the Elekta 1.5 T MRI-linac 7 MV FFF radiation beam. Following acceptance testing, beam characterization data were acquired with Semiflex 3D (PTW 31021), microDiamond (PTW 60019), and Farmer-type (PTW 30013 and IBA FC65-G) detectors in an Elekta...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aab566

    authors: Woodings SJ,Bluemink JJ,de Vries JHW,Niatsetski Y,van Veelen B,Schillings J,Kok JGM,Wolthaus JWH,Hackett SL,van Asselen B,van Zijp HM,Pencea S,Roberts DA,Lagendijk JJW,Raaymakers BW

    更新日期:2018-04-19 00:00:00

  • Imaging placental function: current technology, clinical needs, and emerging modalities.

    abstract::The function of the placenta is challenging to characterize and as a result is understudied, despite the growing awareness of the impact of the placental environment on human health and development. Medical imaging has the potential to improve our ability to screen for diseases associated with placental insufficiency,...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1088/1361-6560/aaccd9

    authors: Wu C,Bayer CL

    更新日期:2018-07-09 00:00:00

  • Front-illuminated versus back-illuminated photon-counting CCD-based gamma camera: important consequences for spatial resolution and energy resolution.

    abstract::Charge-coupled devices (CCDs) coupled to scintillation crystals can be used for high-resolution imaging with x-rays and gamma rays. When the CCD images can be read out fast enough, the energy and interaction position of individual gamma quanta can be estimated by a real-time image analysis of the scintillation light f...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/8/N01

    authors: Heemskerk JW,Westra AH,Linotte PM,Ligtvoet KM,Zbijewski W,Beekman FJ

    更新日期:2007-04-21 00:00:00

  • Spectra from 2.5-15 microm of tissue phantom materials, optical clearing agents and ex vivo human skin: implications for depth profiling of human skin.

    abstract::Infrared measurements have been used to profile or image biological tissue, including human skin. Usually, analysis of such measurements has assumed that infrared absorption is due to water and collagen. Such an assumption may be reasonable for soft tissue, but introduction of exogenous agents into skin or the measure...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/48/2/402

    authors: Viator JA,Choi B,Peavy GM,Kimel S,Nelson JS

    更新日期:2003-01-21 00:00:00

  • Initial assessment of a simple system for frequency domain diffuse optical tomography.

    abstract::Diffuse optical tomography is an imaging technique whereby spatial maps of absorption and scattering coefficients are derived from the characteristics of multiply scattered light transmitted through the object. The system described here used four intensity-modulated light sources and measurements of the intensity and ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/40/10/011

    authors: Pogue BW,Patterson MS,Jiang H,Paulsen KD

    更新日期:1995-10-01 00:00:00

  • 4D maximum a posteriori reconstruction in dynamic SPECT using a compartmental model-based prior.

    abstract::A 4D ordered-subsets maximum a posteriori (OSMAP) algorithm for dynamic SPECT is described which uses a temporal prior that constrains each voxel's behaviour in time to conform to a compartmental model. No a priori limitations on kinetic parameters are applied; rather, the parameter estimates evolve as the algorithm i...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/5/315

    authors: Kadrmas DJ,Gullberg GT

    更新日期:2001-05-01 00:00:00

  • Monte Carlo calculations of the energy response of lithium dosemeters to high energy electrons (less than 30 MeV).

    abstract::Monte Carlo calculations of the energy response of LiF dosemeters have been carried out to help resolve the discrepancy between the measurements of Holt, Edelstein and Clark (1975) and those of Paliwal and Almond (1975) and others. It is concluded that the assumptions used by Holt et al. are largely responsible. They ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/22/5/003

    authors: O'Brien K

    更新日期:1977-09-01 00:00:00

  • PETSIM: Monte Carlo simulation of all sensitivity and resolution parameters of cylindrical positron imaging systems.

    abstract::Monte Carlo simulation techniques are applied to track the annihilation photons from positron decay, and store the photon histories. Reasonably realistic models of the isotope distribution in the brain and heart during typical PET studies, as well as the traditional phantoms used for measuring PET scanner performance ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/37/3/017

    authors: Thompson CJ,Moreno-Cantu J,Picard Y

    更新日期:1992-03-01 00:00:00

  • Prediction of positron emitter distributions for range monitoring in carbon ion therapy: an analytical approach.

    abstract::Range verification is one of the most relevant tasks in ion beam therapy. In the case of carbon ion therapy, positron emission tomography (PET) is the most widely used method for this purpose, which images the [Formula: see text]-activation following nuclear interactions of the ions with the tissue nuclei. Since the p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab17f9

    authors: Hofmann T,Fochi A,Parodi K,Pinto M

    更新日期:2019-05-21 00:00:00

  • Beveled fiber-optic probe couples a ball lens for improving depth-resolved fluorescence measurements of layered tissue: Monte Carlo simulations.

    abstract::In this study, we evaluate the feasibility of designing a beveled fiber-optic probe coupled with a ball lens for improving depth-resolved fluorescence measurements of epithelial tissue using Monte Carlo (MC) simulations. The results show that by using the probe configuration with a beveled tip collection fiber and a f...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/4/008

    authors: Jaillon F,Zheng W,Huang Z

    更新日期:2008-02-21 00:00:00

  • A novel description of FDG excretion in the renal system: application to metformin-treated models.

    abstract::This paper introduces a novel compartmental model describing the excretion of 18F-fluoro-deoxyglucose (FDG) in the renal system and a numerical method based on the maximum likelihood for its reduction. This approach accounts for variations in FDG concentration due to water re-absorption in renal tubules and the increa...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/10/2469

    authors: Garbarino S,Caviglia G,Sambuceti G,Benvenuto F,Piana M

    更新日期:2014-05-21 00:00:00

  • Feasibility of polymer gel-based measurements of radiation isocenter accuracy in magnetic fields.

    abstract::For conventional irradiation devices, the radiation isocenter accuracy is determined by star shot measurements on films. In magnetic resonance (MR)-guided radiotherapy devices, the results of this test may be altered by the magnetic field and the need to align the radiation and imaging isocenter may require a modifica...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aac228

    authors: Dorsch S,Mann P,Lang C,Haering P,Runz A,Karger CP

    更新日期:2018-05-29 00:00:00

  • Automated detection of spinal centrelines, vertebral bodies and intervertebral discs in CT and MR images of lumbar spine.

    abstract::We propose a completely automated algorithm for the detection of the spinal centreline and the centres of vertebral bodies and intervertebral discs in images acquired by computed tomography (CT) and magnetic resonance (MR) imaging. The developed methods are based on the analysis of the geometry of spinal structures an...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/1/015

    authors: Stern D,Likar B,Pernus F,Vrtovec T

    更新日期:2010-01-07 00:00:00

  • Estimation of renal scintigraphy parameters using a linear piecewise-continuous model.

    abstract::Instead of performing a numerical deconvolution, we propose to use a linear piecewise-continuous model of the renal impulse response function for parametric fitting of renal scintigraphy data, to obtain clinically useful renal parameters. The strengths of the present model are its simplicity and speed of computation, ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/48/12/402

    authors: Zhang JL,Zhang L,Koh TS,Shuter B

    更新日期:2003-06-21 00:00:00

  • High-energy radiation monitoring based on radio-fluorogenic co-polymerization. I: Small volume in situ probe.

    abstract::A method of radiation dosimetry is described which is based on the radiation-induced initiation of polymerization of a bulk monomer (e.g. methyl methacrylate) containing a small concentration (about 100 ppm) of a compound which is non-fluorescent but which becomes highly fluorescent when it is incorporated into a grow...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/10/015

    authors: Warman JM,de Haas MP,Luthjens LH

    更新日期:2009-05-21 00:00:00

  • Two-dimensional and quasi-three-dimensional dosimetry of hadron and photon beams with the Magic Cube and the Pixel Ionization Chamber.

    abstract::Two detectors for fast two-dimensional (2D) and quasi-three-dimensional (quasi-3D) verification of the dose delivered by radiotherapy beams have been developed at University and Istituto Nazionale di Fisica Nucleare (INFN) of Torino. The Magic Cube is a stack of strip-segmented ionization chambers interleaved with wat...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/16/017

    authors: Cirio R,Garelli E,Schulte R,Amerio S,Boriano A,Bourhaleb F,Coutrakon G,Donetti M,Giordanengo S,Koss P,Madon E,Marchetto F,Nastasi U,Peroni C,Santuari D,Sardo A,Scielzo G,Stasi M,Trevisiol E

    更新日期:2004-08-21 00:00:00

  • Automated prostate segmentation in whole-body MRI scans for epidemiological studies.

    abstract::The whole prostatic volume (PV) is an important indicator for benign prostate hyperplasia. Correlating the PV with other clinical parameters in a population-based prospective cohort study (SHIP-2) requires valid prostate segmentation in a large number of whole-body MRI scans. The axial proton density fast spin echo fa...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/17/5899

    authors: Habes M,Schiller T,Rosenberg C,Burchardt M,Hoffmann W

    更新日期:2013-09-07 00:00:00

  • Monte Carlo calculations of beam quality correction factors kQ for electron dosimetry with a parallel-plate Roos chamber.

    abstract::Current dosimetry protocols (AAPM, IAEA, DIN) recommend the use of parallel-plate ionization chambers for the measurement of absorbed dose-to-water in clinical electron beams. For well-guarded plane-parallel chambers, it is assumed that the perturbation correction pQ is unity for all electron energies. In this study, ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/6/006

    authors: Zink K,Wulff J

    更新日期:2008-03-21 00:00:00

  • Blood irradiation with accelerator produced electron beams.

    abstract::Blood and blood products are irradiated with gamma rays to reduce the risk of graft versus host disease (GVHD). A simple technique using electron beams produced by a medical linear accelerator has been studied to evaluate irradiation of blood and blood products. Variations in applied doses for a single field 20 MeV el...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/11/401

    authors: Butson MJ,Cheung T,Yu PK,Stokes MJ

    更新日期:2000-11-01 00:00:00

  • Energy and spatial distribution of multiple order Compton scatter in SPECT: a Monte Carlo investigation.

    abstract::Energy and spatial projection distributions were simulated for gamma camera imaging of multiple order Compton scattered photons. SPECT imaging of a line source of radioactivity located in a water filled cylindrical phantom was modelled using Monte Carlo techniques. Photon trajectories were followed from emission to de...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/29/10/005

    authors: Floyd CE,Jaszczak RJ,Harris CC,Coleman RE

    更新日期:1984-10-01 00:00:00

  • Effects of tissue mechanical and acoustic anisotropies on the performance of a cross-correlation-based ultrasound strain imaging method.

    abstract::The anisotropic mechanical properties (mechanical anisotropy) and view-dependent ultrasonic backscattering (acoustic anisotropy) of striated muscle due to the underlying myofiber arrangement have been well documented, but whether they impact on ultrasound strain imaging (USI) techniques remains unclear. The aim of thi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa530b

    authors: Li H,Lee WN

    更新日期:2017-02-21 00:00:00

  • 19F MRI oximetry: simulation of perfluorocarbon distribution impact.

    abstract::In (19)F MRI oximetry, a method used to image tumour hypoxia, perfluorocarbons serve as oxygenation markers. The goal of this study is to evaluate the impact of perfluorocarbon distribution and concentration in (19)F MRI oximetry through a computer simulation. The simulation studies the correspondence between (19)F me...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/8/013

    authors: Baete SH,Vandecasteele J,De Deene Y

    更新日期:2011-04-21 00:00:00

  • Monte Carlo generated mammograms: development and validation.

    abstract::We have developed a model using Monte Carlo methods to simulate x-ray mammography. All possible physical processes of interaction of x-rays with matter have been taken into account. A simplified geometry of the mammographic apparatus has been considered along with a software phantom of compressed breast. The phantom m...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/11/012

    authors: Spyrou G,Tzanakos G,Bakas A,Panayiotakis G

    更新日期:1998-11-01 00:00:00

  • Distributed three-dimensional simulation of B-mode ultrasound imaging using a first-order k-space method.

    abstract::Computational modeling is an important tool in ultrasound imaging research, but realistic three-dimensional (3D) simulations can exceed the capabilities of serial computers. This paper uses a 3D simulator based on a k-space method that incorporates relaxation absorption and nonreflecting boundary conditions. The simul...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/17/007

    authors: Daoud MI,Lacefield JC

    更新日期:2009-09-07 00:00:00