Automated prostate segmentation in whole-body MRI scans for epidemiological studies.


:The whole prostatic volume (PV) is an important indicator for benign prostate hyperplasia. Correlating the PV with other clinical parameters in a population-based prospective cohort study (SHIP-2) requires valid prostate segmentation in a large number of whole-body MRI scans. The axial proton density fast spin echo fat saturated sequence is used for prostate screening in SHIP-2. Our automated segmentation method is based on support vector machines (SVM). We used three-dimensional neighborhood information to build classification vectors from automatically generated features and randomly selected 16 MR examinations for validation. The Hausdorff distance reached a mean value of 5.048 ± 2.413, and a mean value of 5.613 ± 2.897 compared to manual segmentation by observers A and B. The comparison between volume measurement of SVM-based segmentation and manual segmentation of observers A and B depicts a strong correlation resulting in Spearman's rank correlation coefficients (ρ) of 0.936 and 0.859, respectively. Our automated methodology based on SVM for prostate segmentation can segment the prostate in WBI scans with good segmentation quality and has considerable potential for integration in epidemiological studies.


Phys Med Biol


Habes M,Schiller T,Rosenberg C,Burchardt M,Hoffmann W




Has Abstract


2013-09-07 00:00:00












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    abstract::Proton beams used for radiotherapy will produce neutrons when interacting with matter. The purpose of this study was to quantify the equivalent dose to tissue due to secondary neutrons in pediatric and adult patients treated by proton therapy for brain lesions. Assessment of the equivalent dose to organs away from the...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Zacharatou Jarlskog C,Lee C,Bolch WE,Xu XG,Paganetti H

    更新日期:2008-02-07 00:00:00

  • Effect of material property heterogeneity on biomechanical modeling of prostate under deformation.

    abstract::Biomechanical model based deformable image registration has been widely used to account for prostate deformation in various medical imaging procedures. Biomechanical material properties are important components of a biomechanical model. In this study, the effect of incorporating tumor-specific material properties in t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Samavati N,McGrath DM,Jewett MA,van der Kwast T,Ménard C,Brock KK

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  • A depth-encoding PET detector for high resolution PET using 1 mm SiPMs.

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Du J,Bai X,Cherry SR

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  • Investigation of detection limits for diffuse optical tomography systems: II. Analysis of slab and cup geometry for breast imaging.

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Ziegler R,Brendel B,Rinneberg H,Nielsen T

    更新日期:2009-01-21 00:00:00

  • The relevance of very low energy ions for heavy-ion therapy.

    abstract::Heavy-ion radiotherapy exploits the high biological effectiveness of localized energy deposition delivered by so-called Bragg-peak particles. Recent publications have challenged the established procedures to calculate biological effective dose distributions in treatment planning. They emphasize the importance of very ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Elsässer T,Gemmel A,Scholz M,Schardt D,Krämer M

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  • An age-dependent series of eye models for radiation dosimetry.

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    pub_type: 杂志文章


    authors: Vejdani-Noghreiyan A,Ebrahimi-Khankook A

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


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  • Microwave thermal ablation using CT-scanner for predicting the variation of ablated region over time: advantages and limitations.

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Jaszczak M,Wach R,Maras P,Dudek M,Kozicki M

    更新日期:2018-09-06 00:00:00

  • Are phantoms useful for predicting the potential of dose reduction in full-field digital mammography?

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    pub_type: 杂志文章


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    journal_title:Physics in medicine and biology

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  • Anatomically-aided PET reconstruction using the kernel method.

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    journal_title:Physics in medicine and biology

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    authors: Kiss MZ,Sayers DE,Zhong Z

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  • Monitor unit calculation on the beam axis of open and wedged asymmetric high-energy photon beams.

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Georg D

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    journal_title:Physics in medicine and biology

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    authors: Paelinck L,De Wagter C,Van Esch A,Duthoy W,Depuydt T,De Neve W

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    authors: Unkelbach J,Oelfke U

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Eklund K,Ahnesjö A

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  • Neutron scattering cross sections and partial kerma values for oxygen, nitrogen and calcium at 18 less than En less than 60 MeV.

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    authors: Islam MS,Finlay RW,Petler JS,Rapaport J,Alarcon R,Wierzbicki J

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  • Staging of cervical cancer based on tumor heterogeneity characterized by texture features on (18)F-FDG PET images.

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    journal_title:Physics in medicine and biology

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    authors: Mu W,Chen Z,Liang Y,Shen W,Yang F,Dai R,Wu N,Tian J

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  • A new extended-length parallel-plate ionization chamber.

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    journal_title:Physics in medicine and biology

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    authors: Maia AF,Caldas LV

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  • Global point signature for shape analysis of carpal bones.

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  • Investigation of a scanned cylindrical ultrasound system for breast hyperthermia.

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    journal_title:Physics in medicine and biology

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    authors: Ju KC,Tseng LT,Chen YY,Lin WL

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  • Radiation damage, repopulation and cell recovery analysis of in vitro tumour cell megacolony culture data using a non-Poissonian cell repopulation TCP model.

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Stavrev P,Weldon M,Warkentin B,Stavreva N,Fallone BG

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  • Computational dosimetry in embryos exposed to electromagnetic plane waves over the frequency range of 10 MHz-1.5 GHz.

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Kawai H,Nagaoka T,Watanabe S,Saito K,Takahashi M,Ito K

    更新日期:2010-01-07 00:00:00

  • Building an open-source simulation platform of acoustic radiation force-based breast elastography.

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Wang Y,Peng B,Jiang J

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  • Long-length tomosynthesis and 3D-2D registration for intraoperative assessment of spine instrumentation.

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Zhang X,Uneri A,Wu P,Ketcha MD,Jones C,Huang Y,Lo SL,Helm PA,Siewerdsen JH

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Evans PM,Symonds-Tayler JR,Colgan R,Hugo GD,Letts N,Sandin C

    更新日期:2010-04-21 00:00:00

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    journal_title:Physics in medicine and biology

    pub_type: 杂志文章


    authors: Piessens M,Reynaert N

    更新日期:2000-08-01 00:00:00