Abstract:
:In this study, we evaluate the feasibility of designing a beveled fiber-optic probe coupled with a ball lens for improving depth-resolved fluorescence measurements of epithelial tissue using Monte Carlo (MC) simulations. The results show that by using the probe configuration with a beveled tip collection fiber and a flat tip excitation fiber associated with a ball lens, discrimination of fluorescence signals generated in different tissue depths is achievable. In comparison with a flat-tip collection fiber, the use of a large bevel angled collection fiber enables a better differentiation between the shallow and deep tissue layers by changing the excitation-collection fiber separations. This work suggests that the beveled fiber-optic probe coupled with a ball lens has the potential to facilitate depth-resolved fluorescence measurements of epithelial tissues.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Jaillon F,Zheng W,Huang Zdoi
10.1088/0031-9155/53/4/008subject
Has Abstractpub_date
2008-02-21 00:00:00pages
937-51issue
4eissn
0031-9155issn
1361-6560pii
S0031-9155(08)61611-5journal_volume
53pub_type
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