Neuropsychological study of IQ scores in offspring of parents with bipolar I disorder.

Abstract:

INTRODUCTION:Studies comparing IQ in Offspring of Bipolar Parents (OBP) with Offspring of Healthy Controls (OHC) have reported conflicting findings. They have included OBP with mental health/neurodevelopmental disorders and/or pharmacological treatment which could affect results. This UK study aimed to assess IQ in OBP with no mental health/neurodevelopmental disorder and assess the relationship of sociodemographic variables with IQ. METHODS:IQ data using the Wechsler Abbreviated Scale of Intelligence (WASI) from 24 OBP and 34 OHC from the North East of England was analysed using mixed-effects modelling. RESULTS:All participants had IQ in the average range. OBP differed statistically significantly from OHC on Full Scale IQ (p = .001), Performance IQ (PIQ) (p = .003) and Verbal IQ (VIQ) (p = .001) but not on the PIQ-VIQ split. OBP and OHC groups did not differ on socio-economic status (SES) and gender. SES made a statistically significant contribution to the variance of IQ scores (p = .001). CONCLUSIONS:Using a robust statistical model of analysis, the OBP with no current/past history of mental health/neurodevelopmental disorders had lower IQ scores compared to OHC. This finding should be borne in mind when assessing and recommending interventions for OBP.

journal_name

Cogn Neuropsychiatry

authors

Sharma A,Camilleri N,Grunze H,Barron E,Le Couteur J,Close A,Rushton S,Kelly T,Ferrier IN,Le Couteur A

doi

10.1080/13546805.2016.1259103

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

17-27

issue

1

eissn

1354-6805

issn

1464-0619

journal_volume

22

pub_type

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