Abstract:
BACKGROUND:Substance abuse is highly prevalent in schizophrenia and it has been associated with negative consequences on the course of the pathology. Regarding cognition, the prevailing literature has produced mixed results. Some groups have reported greater cognitive impairments in dual diagnosis schizophrenia, while other groups have described the reverse. OBJECTIVE:The current cross-sectional study sought to investigate the potential differences in psychiatric symptoms and cognition between schizophrenia patients with and without substance use disorders. METHODS:Fifty-three schizophrenia patients were divided into two groups: with (n=30) and without (n=23) a substance use disorder (DSM-IV criteria). Psychiatric symptoms were measured with the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS). Psychomotor speed and spatial working memory were measured using Cambridge Neuropsychological Tests Automated Battery (CANTAB). RESULTS:Patients in the dual diagnosis group displayed more severe depressive symptoms and poorer strategy during the working memory task. CONCLUSIONS:These results are in keeping with the prevailing literature describing negative consequences of substance abuse in schizophrenia. Substance abuse may exacerbate depressive symptoms and interfere with metacognition in schizophrenia.
journal_name
Cogn Neuropsychiatryjournal_title
Cognitive neuropsychiatryauthors
Potvin S,Pampoulova T,Lipp O,Ait Bentaleb L,Lalonde P,Stip Edoi
10.1080/13546800802264330subject
Has Abstractpub_date
2008-07-01 00:00:00pages
357-66issue
4eissn
1354-6805issn
1464-0619pii
794909005journal_volume
13pub_type
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