Abstract:
:Numerous genes modulate dopamine and consequently prefrontal cortical function. Some of these genes - notably catechol-O-methyltransferase - have been shown to impact a variety of core cognitive processes that are dependent upon the prefrontal cortex. This demonstration that a single functional polymorphism can contribute so dramatically to individual differences heralds a new era for neuropsychiatry. Although enormous detail remains to be discovered about these various genes that regulate neurotransmitters, how they interact and how they affect brain systems, there is much excitement and promise regarding new neuropsychopharmacological possibilities. However, this new research program is magnitudes more complex than any enterprise embarked on hitherto and requires the development, validation and deployment of novel behavioural and neurophysiological phenotypes in order to unravel the pathologies within neural functional systems. This research foundation is essential if these genetic breakthroughs are to be translated to successful clinical agents.
journal_name
Cogn Neuropsychiatryjournal_title
Cognitive neuropsychiatryauthors
Elvevåg B,Weinberger DRdoi
10.1080/13546800903126016subject
Has Abstractpub_date
2009-01-01 00:00:00pages
261-76issue
4-5eissn
1354-6805issn
1464-0619pii
913383287journal_volume
14pub_type
abstract:INTRODUCTION:Although social cognition skills and biases are well-studied in paranoia, "mind perception" - perceiving the extent to which someone even possesses a thinking, feeling mind - is not. We sought to better characterise the profile of mind perception for individuals with paranoia. METHODS:We examined links be...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2017.1287692
更新日期:2017-03-01 00:00:00
abstract::Introduction: Predictive coding models propose that high hypnotic suggestibility confers a predisposition to hallucinate due to an elevated propensity to weight perceptual beliefs (priors) over sensory evidence. Multiple lines of research corroborate this prediction and demonstrate a link between hypnotic suggestibili...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2020.1715932
更新日期:2020-05-01 00:00:00
abstract:INTRODUCTION:We have previously reported that people with schizophrenia and formal thought disorder (FTD) were disproportionately impaired in recalling sentences verbatim and in judging their plausibility. We proposed that these deficits were due to impairment in integrating higher-order semantic information to constru...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2013.870069
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:We report a novel delusion, primarily persecutory in form, in which the patient believes that he is being filmed, and that the films are being broadcast for the entertainment of others. METHODS:We describe a series of patients who presented with a delusional system according to which they were the subject...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2012.666113
更新日期:2012-11-01 00:00:00
abstract::Cognitive Neuropsychiatry has secured recognition in Thomson's Science and Social Science Citation Indices which will lead to the calculation of the journal impact factor. ...
journal_title:Cognitive neuropsychiatry
pub_type: 社论
doi:10.1080/13546805.2012.715800
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:It is assumed that people spontaneously evaluate any incoming stimulus as pleasant or unpleasant. The evaluative response appears to structure perception and to have direct links to emotional states. METHODS:To investigate the automatic processing of face valence a sequential priming task based on emotion...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800344000318
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Patients with schizophrenia show impairments in working-memory and visual-spatial processing, but little is known about the dynamic interplay between the two. To provide insight into this important question, we examined the effect of positive and negative symptom expressions in healthy adults on perceptual...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2016.1206873
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Previous research suggests that latent inhibition is reduced in patients with acute schizophrenia and in healthy participants with high levels of schizotypic characteristics. Other evidence indicates the disruption of a related effect (learned irrelevance) in patients with acute schizophrenia. METHOD:This...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800802664539
更新日期:2009-01-01 00:00:00
abstract::We describe a case of transient functional retrograde amnesia that had features of a fugue state, and that was accompanied by loss of personal identity and significant autobiographical amnesia. Uniquely, we were able to gather information from witnesses who observed the episode from its onset, and we were also able to...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/135468096396541
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Cohen et al.'s (1990, 1999) concept of context has been employed to explain various schizophrenic cognitive deficits. Braver et al.'s (2001) modified definition allows us to link context to cognitive complexity and explain a range of our experimental findings. METHOD:Saccadic and manual responses to experim...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800802058658
更新日期:2008-05-01 00:00:00
abstract:INTRODUCTION:Research on empathy has a long tradition in clinical research, as deficits in empathy have been found in many mental disorders. Over decades, a large amount of measures for empathy have been developed, but in many cases these have not been analysed with respect to validity. Therefore, this paper aims to re...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2014.991781
更新日期:2015-01-01 00:00:00
abstract::Introduction: Cognitive impairments are common in both Autism Spectrum Disorders (ASD) and schizophrenia, but it is unclear whether the pattern of difficulties is similar or different in the two disorders. This cross-sectional and longitudinal study compared the neuropsychological functioning in adolescents with ASD w...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2020.1713736
更新日期:2020-05-01 00:00:00
abstract:INTRODUCTION:Visual scanning is widely reported to be abnormal in schizophrenia. The majority of eye movement studies in schizophrenic patients have used pictures of a face in isolation in free viewings. This study was designed to examine whether attentional control, through instructions, modulates the visuomotor behav...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2012.683245
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:Little is known about the relationship between cognitive dysfunction and functional disability in alcohol dependence with comorbid affective disorders. We investigated the neuropsychology of alcohol dependence in detoxified adults with and without affective comorbidity and examined the factors associated w...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2015.1014031
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Theory-of-mind (ToM) refers to the ability to understand and predict the behaviour of others based on their mental states. Research from brain imaging and lesion studies indicate that the frontal lobes are both involved and necessary to understand mental states. METHODS:A total of 13 people with Parkinson...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800244000292
更新日期:2003-08-01 00:00:00
abstract::The psychopathological basis of delusions in schizophrenia is poorly understood. The most enduring of several early theories has suggested a causal link with formal thought disorder, whereas recent approaches have proposed relationships with a variety of cognitive abnormalities. The correlations of delusions with othe...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/135468096396451
更新日期:1996-11-01 00:00:00
abstract:INTRODUCTION:There is substantial evidence that patients with schizophrenia present with impaired Theory of Mind (ToM). Whereas previous studies have focused on general ToM abilities, the present study is aimed at testing the underlying behavioural and neurocognitive mechanisms of the impaired integration of affective ...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800802490034
更新日期:2008-11-01 00:00:00
abstract:INTRODUCTION:Cognitive remediation therapy (CRT) has been reported to positively affect neurocognitive processes among patients with schizophrenia; however, the degree to which changes in cognition is linked to improved clinical symptoms, remains poorly understood. The current study aimed to investigate whether cogniti...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1080/13546805.2016.1260537
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Cognitive neuropsychiatry has had much success in providing theoretical models for the causal origins of many delusional beliefs. Recently, it has been suggested that some anorexia nervosa patients' beliefs about their own body size should be considered delusions. As such, it seems high time the methods of...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2017.1401531
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Most evidence suggests that schizophrenia is associated with pervasive prospective memory (PM) impairment that does not vary as a function of task demands. However, a central tenet of the Multiprocess Framework is that PM involves both automatic and strategic processes, and that their relative prominence v...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2011.581536
更新日期:2012-01-01 00:00:00
abstract::Introduction: Studies have documented both executive functions (EF) impairment in children with Attention Deficit / Hyperactivity Disorders (ADHD) and Theory of Mind (ToM), yielding mixed results, possibly because of a variety of tasks used, all requiring different levels of language skills.Aim: To investigate the rel...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2019.1681951
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Although there is evidence for language abnormality in schizophrenia, few studies have examined sign language in deaf patients with the disorder. This is of potential interest because a hallmark of sign languages is their use of classifiers (semantic or entity classifiers), a reference-tracking device with...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2018.1476227
更新日期:2018-07-01 00:00:00
abstract:INTRODUCTION:There is evidence that schizophrenics have an abnormal corpus callosum and an abnormal pattern of cerebral asymmetries. We investigated whether there are corresponding functional abnormalities in interhemispheric transfer (IT) and laterality effects. METHODS:Medicated schizophrenic patients and matched co...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800143000195
更新日期:2002-05-01 00:00:00
abstract:INTRODUCTION:Category fluency is associated with speed-, executive- and semantic impairments in schizphrenia. It has traditionally been linked to negative symptoms, whereas the relation to positive symptoms is mixed. Associations to the consensus negative, positive and disorganisation factors have not been analysed bef...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1080/13546805.2017.1418306
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Individuals with schizophrenia, particularly those with passivity symptoms, often feel that their actions and thoughts are controlled by an external agent. Recent evidence has elucidated the role of body representations in the aetiology of passivity symptoms, yet one representation - body structural descri...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2016.1231111
更新日期:2016-07-01 00:00:00
abstract::The thalamus has been described as a "relay station" for sensory information from most sensory modalities projecting to cortical areas. Therefore injury to the thalamus may result in multimodal sensory and motor deficits. In the present study, a 61-year-old woman suffered a right thalamic cerebral vascular accident (C...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800701319094
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:In this paper, we argue for a novel account of one cognitive factor implicated in delusional cognition. According to the erotetic theory of delusion we present, the central cognitive factor in delusion is impaired endogenous question raising. METHOD:After presenting the erotetic theory, we draw on it to m...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2015.1067601
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The aim of the present study was to compare spatial working memory performance of females and males schizophrenia patients to verify whether the sexual dimorphism of spatial abilities present in the general population is found also in schizophrenia. METHODS:We analysed different types of errors committed ...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800903399183
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:We investigated the relationship of insight with executive functions and symptoms in a group of stabilised inpatients with schizophrenia. METHODS:Executive functions using an extensive battery constituted of several tests as well as psychopathology were assessed in 38 inpatients with a DSM-IV diagnosis of...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800444000308
更新日期:2006-09-01 00:00:00
abstract::Introduction: Cognitive impairment is related to an increase in cardiovascular risk (CVR) in the general population. However, in severe mental disorder (SMD), the evidence is less consistent. Few studies have evaluated the relationship between cognition and vascular burden in SMD. This study determines the relationshi...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2019.1676709
更新日期:2020-01-01 00:00:00