Introduction: genes, cognition and neuropsychiatry.

Abstract:

:Numerous genes modulate dopamine and consequently prefrontal cortical function. Some of these genes - notably catechol-O-methyltransferase - have been shown to impact a variety of core cognitive processes that are dependent upon the prefrontal cortex. This demonstration that a single functional polymorphism can contribute so dramatically to individual differences heralds a new era for neuropsychiatry. Although enormous detail remains to be discovered about these various genes that regulate neurotransmitters, how they interact and how they affect brain systems, there is much excitement and promise regarding new neuropsychopharmacological possibilities. However, this new research program is magnitudes more complex than any enterprise embarked on hitherto and requires the development, validation and deployment of novel behavioural and neurophysiological phenotypes in order to unravel the pathologies within neural functional systems. This research foundation is essential if these genetic breakthroughs are to be translated to successful clinical agents.

journal_name

Cogn Neuropsychiatry

authors

Elvevåg B,Weinberger DR

doi

10.1080/13546800903126016

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

261-76

issue

4-5

eissn

1354-6805

issn

1464-0619

pii

913383287

journal_volume

14

pub_type

  • Differential patterns in mind perception in subclinical paranoia: relationships to self-reported empathy.

    abstract:INTRODUCTION:Although social cognition skills and biases are well-studied in paranoia, "mind perception" - perceiving the extent to which someone even possesses a thinking, feeling mind - is not. We sought to better characterise the profile of mind perception for individuals with paranoia. METHODS:We examined links be...

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    pub_type: 杂志文章

    doi:10.1080/13546805.2017.1287692

    authors: Buck B,Hester N,Penn DL,Gray K

    更新日期:2017-03-01 00:00:00

  • Anomalous experiences are more prevalent among highly suggestible individuals who are also highly dissociative.

    abstract::Introduction: Predictive coding models propose that high hypnotic suggestibility confers a predisposition to hallucinate due to an elevated propensity to weight perceptual beliefs (priors) over sensory evidence. Multiple lines of research corroborate this prediction and demonstrate a link between hypnotic suggestibili...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2020.1715932

    authors: Acunzo D,Cardeña E,Terhune DB

    更新日期:2020-05-01 00:00:00

  • Verbatim recall in formal thought disorder in schizophrenia: a study of contextual influences.

    abstract:INTRODUCTION:We have previously reported that people with schizophrenia and formal thought disorder (FTD) were disproportionately impaired in recalling sentences verbatim and in judging their plausibility. We proposed that these deficits were due to impairment in integrating higher-order semantic information to constru...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2013.870069

    authors: Dwyer K,Peters E,McKenna P,David A,McCarthy R

    更新日期:2014-01-01 00:00:00

  • The "Truman Show" delusion: psychosis in the global village.

    abstract:INTRODUCTION:We report a novel delusion, primarily persecutory in form, in which the patient believes that he is being filmed, and that the films are being broadcast for the entertainment of others. METHODS:We describe a series of patients who presented with a delusional system according to which they were the subject...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2012.666113

    authors: Gold J,Gold I

    更新日期:2012-11-01 00:00:00

  • Making an impact.

    abstract::Cognitive Neuropsychiatry has secured recognition in Thomson's Science and Social Science Citation Indices which will lead to the calculation of the journal impact factor. ...

    journal_title:Cognitive neuropsychiatry

    pub_type: 社论

    doi:10.1080/13546805.2012.715800

    authors: David AS,Halligan PW

    更新日期:2012-01-01 00:00:00

  • Automatic processing of facial emotion in schizophrenia with and without affective negative symptoms.

    abstract:INTRODUCTION:It is assumed that people spontaneously evaluate any incoming stimulus as pleasant or unpleasant. The evaluative response appears to structure perception and to have direct links to emotional states. METHODS:To investigate the automatic processing of face valence a sequential priming task based on emotion...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546800344000318

    authors: Suslow T,Droste T,Roestel C,Arolt V

    更新日期:2005-01-01 00:00:00

  • Visual-spatial processing and working-memory load as a function of negative and positive psychotic-like experiences.

    abstract:INTRODUCTION:Patients with schizophrenia show impairments in working-memory and visual-spatial processing, but little is known about the dynamic interplay between the two. To provide insight into this important question, we examined the effect of positive and negative symptom expressions in healthy adults on perceptual...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2016.1206873

    authors: Abu-Akel A,Reniers RL,Wood SJ

    更新日期:2016-09-01 00:00:00

  • Latent inhibition, learned irrelevance, and schizotypy: assessing their relationship.

    abstract:INTRODUCTION:Previous research suggests that latent inhibition is reduced in patients with acute schizophrenia and in healthy participants with high levels of schizotypic characteristics. Other evidence indicates the disruption of a related effect (learned irrelevance) in patients with acute schizophrenia. METHOD:This...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546800802664539

    authors: Schmidt-Hansen M,Killcross AS,Honey RC

    更新日期:2009-01-01 00:00:00

  • A study of recovery of memory function in a case of witnessed functional retrograde amnesia.

    abstract::We describe a case of transient functional retrograde amnesia that had features of a fugue state, and that was accompanied by loss of personal identity and significant autobiographical amnesia. Uniquely, we were able to gather information from witnesses who observed the episode from its onset, and we were also able to...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/135468096396541

    authors: Kapur N

    更新日期:1996-08-01 00:00:00

  • Context, complexity, and cognitive processing in schizophrenia.

    abstract:BACKGROUND:Cohen et al.'s (1990, 1999) concept of context has been employed to explain various schizophrenic cognitive deficits. Braver et al.'s (2001) modified definition allows us to link context to cognitive complexity and explain a range of our experimental findings. METHOD:Saccadic and manual responses to experim...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546800802058658

    authors: Schooler C,Roberts B,Cohen R

    更新日期:2008-05-01 00:00:00

  • Assessment of empathy via self-report and behavioural paradigms: data on convergent and discriminant validity.

    abstract:INTRODUCTION:Research on empathy has a long tradition in clinical research, as deficits in empathy have been found in many mental disorders. Over decades, a large amount of measures for empathy have been developed, but in many cases these have not been analysed with respect to validity. Therefore, this paper aims to re...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2014.991781

    authors: Melchers M,Montag C,Markett S,Reuter M

    更新日期:2015-01-01 00:00:00

  • Similar impairments shown on a neuropsychological test battery in adolescents with high-functioning autism and early onset schizophrenia: a two-year follow-up study.

    abstract::Introduction: Cognitive impairments are common in both Autism Spectrum Disorders (ASD) and schizophrenia, but it is unclear whether the pattern of difficulties is similar or different in the two disorders. This cross-sectional and longitudinal study compared the neuropsychological functioning in adolescents with ASD w...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2020.1713736

    authors: Øie MG,Andersen PN,Hovik KT,Skogli EW,Rund BR

    更新日期:2020-05-01 00:00:00

  • Visual exploration and action processing in schizophrenia.

    abstract:INTRODUCTION:Visual scanning is widely reported to be abnormal in schizophrenia. The majority of eye movement studies in schizophrenic patients have used pictures of a face in isolation in free viewings. This study was designed to examine whether attentional control, through instructions, modulates the visuomotor behav...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2012.683245

    authors: Delerue C,Boucart M

    更新日期:2013-05-01 00:00:00

  • Cognitive dysfunction and functional disability in alcohol-dependent adults with or without a comorbid affective disorder.

    abstract:INTRODUCTION:Little is known about the relationship between cognitive dysfunction and functional disability in alcohol dependence with comorbid affective disorders. We investigated the neuropsychology of alcohol dependence in detoxified adults with and without affective comorbidity and examined the factors associated w...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2015.1014031

    authors: Lee RS,Dore G,Juckes L,De Regt T,Naismith SL,Lagopoulos J,Tickell A,Hickie IB,Hermens DF

    更新日期:2015-01-01 00:00:00

  • Is theory-of-mind impaired in Parkinson's disease?

    abstract:INTRODUCTION:Theory-of-mind (ToM) refers to the ability to understand and predict the behaviour of others based on their mental states. Research from brain imaging and lesion studies indicate that the frontal lobes are both involved and necessary to understand mental states. METHODS:A total of 13 people with Parkinson...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546800244000292

    authors: Mengelberg A,Siegert RJ

    更新日期:2003-08-01 00:00:00

  • Delusions in schizophrenia: a phenomenological and psychological exploration.

    abstract::The psychopathological basis of delusions in schizophrenia is poorly understood. The most enduring of several early theories has suggested a causal link with formal thought disorder, whereas recent approaches have proposed relationships with a variety of cognitive abnormalities. The correlations of delusions with othe...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/135468096396451

    authors: Bentham AM,McKay AP,Quemada I,Clare L,Eastwood N,McKenna PJ

    更新日期:1996-11-01 00:00:00

  • Integration of emotional and cognitive aspects of theory of mind in schizophrenia and its relation to prefrontal neurocognitive performance.

    abstract:INTRODUCTION:There is substantial evidence that patients with schizophrenia present with impaired Theory of Mind (ToM). Whereas previous studies have focused on general ToM abilities, the present study is aimed at testing the underlying behavioural and neurocognitive mechanisms of the impaired integration of affective ...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546800802490034

    authors: Shur S,Shamay-Tsoory SG,Levkovitz Y

    更新日期:2008-11-01 00:00:00

  • Effects of cognitive remediation therapy on neurocognition and negative symptoms in schizophrenia: an Italian naturalistic study.

    abstract:INTRODUCTION:Cognitive remediation therapy (CRT) has been reported to positively affect neurocognitive processes among patients with schizophrenia; however, the degree to which changes in cognition is linked to improved clinical symptoms, remains poorly understood. The current study aimed to investigate whether cogniti...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/13546805.2016.1260537

    authors: Lanfredi M,Deste G,Ferrari C,Barlati S,Magni LR,Rossi R,de Peri L,Bonomi M,Rossi G,Vita A

    更新日期:2017-01-01 00:00:00

  • Explaining body size beliefs in anorexia.

    abstract:INTRODUCTION:Cognitive neuropsychiatry has had much success in providing theoretical models for the causal origins of many delusional beliefs. Recently, it has been suggested that some anorexia nervosa patients' beliefs about their own body size should be considered delusions. As such, it seems high time the methods of...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2017.1401531

    authors: Gadsby S

    更新日期:2017-11-01 00:00:00

  • Prospective memory in schizophrenia and schizotypy.

    abstract:INTRODUCTION:Most evidence suggests that schizophrenia is associated with pervasive prospective memory (PM) impairment that does not vary as a function of task demands. However, a central tenet of the Multiprocess Framework is that PM involves both automatic and strategic processes, and that their relative prominence v...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2011.581536

    authors: Henry JD,Rendell PG,Rogers P,Altgassen M,Kliegel M

    更新日期:2012-01-01 00:00:00

  • A new semi-nonverbal task glance, moderate role of cognitive flexibility in ADHD children's theory of mind.

    abstract::Introduction: Studies have documented both executive functions (EF) impairment in children with Attention Deficit / Hyperactivity Disorders (ADHD) and Theory of Mind (ToM), yielding mixed results, possibly because of a variety of tasks used, all requiring different levels of language skills.Aim: To investigate the rel...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2019.1681951

    authors: Mohammadzadeh A,Khorrami Banaraki A,Tehrani Doost M,Castelli F

    更新日期:2020-01-01 00:00:00

  • Language abnormality in deaf people with schizophrenia: a problem with classifiers.

    abstract:INTRODUCTION:Although there is evidence for language abnormality in schizophrenia, few studies have examined sign language in deaf patients with the disorder. This is of potential interest because a hallmark of sign languages is their use of classifiers (semantic or entity classifiers), a reference-tracking device with...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2018.1476227

    authors: Chatzidamianos G,McCarthy RA,Du Feu M,Rosselló J,McKenna PJ

    更新日期:2018-07-01 00:00:00

  • Interhemispheric transfer and laterality effects in simple visual reaction time in schizophrenics.

    abstract:INTRODUCTION:There is evidence that schizophrenics have an abnormal corpus callosum and an abnormal pattern of cerebral asymmetries. We investigated whether there are corresponding functional abnormalities in interhemispheric transfer (IT) and laterality effects. METHODS:Medicated schizophrenic patients and matched co...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546800143000195

    authors: Florio V,Fossella S,Maravita A,Miniussi C,Marzi CA

    更新日期:2002-05-01 00:00:00

  • Category fluency in schizophrenia: opposing effects of negative and positive symptoms?

    abstract:INTRODUCTION:Category fluency is associated with speed-, executive- and semantic impairments in schizphrenia. It has traditionally been linked to negative symptoms, whereas the relation to positive symptoms is mixed. Associations to the consensus negative, positive and disorganisation factors have not been analysed bef...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/13546805.2017.1418306

    authors: Egeland J,Holmen TL,Bang-Kittilsen G,Bigseth TT,Engh JA

    更新日期:2018-01-01 00:00:00

  • Body representations in schizophrenia: an alteration of body structural description is common to people with schizophrenia while alterations of body image worsen with passivity symptoms.

    abstract:INTRODUCTION:Individuals with schizophrenia, particularly those with passivity symptoms, often feel that their actions and thoughts are controlled by an external agent. Recent evidence has elucidated the role of body representations in the aetiology of passivity symptoms, yet one representation - body structural descri...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2016.1231111

    authors: Graham-Schmidt KT,Martin-Iverson MT,Holmes NP,Waters F

    更新日期:2016-07-01 00:00:00

  • Asymmetry in the emotional content of lateralised multimodal hallucinations following right thalamic stroke.

    abstract::The thalamus has been described as a "relay station" for sensory information from most sensory modalities projecting to cortical areas. Therefore injury to the thalamus may result in multimodal sensory and motor deficits. In the present study, a 61-year-old woman suffered a right thalamic cerebral vascular accident (C...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546800701319094

    authors: Mollet GA,Harrison DW,Walters RP,Foster PS

    更新日期:2007-09-01 00:00:00

  • The erotetic theory of delusional thinking.

    abstract:INTRODUCTION:In this paper, we argue for a novel account of one cognitive factor implicated in delusional cognition. According to the erotetic theory of delusion we present, the central cognitive factor in delusion is impaired endogenous question raising. METHOD:After presenting the erotetic theory, we draw on it to m...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2015.1067601

    authors: Parrott M,Koralus P

    更新日期:2015-01-01 00:00:00

  • Sexual dimorphism of spatial working memory profiles in schizophrenia.

    abstract:INTRODUCTION:The aim of the present study was to compare spatial working memory performance of females and males schizophrenia patients to verify whether the sexual dimorphism of spatial abilities present in the general population is found also in schizophrenia. METHODS:We analysed different types of errors committed ...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546800903399183

    authors: Lecardeur L,Mendrek A,Stip E

    更新日期:2010-07-01 00:00:00

  • Insight, symptoms and executive functions in schizophrenia.

    abstract:INTRODUCTION:We investigated the relationship of insight with executive functions and symptoms in a group of stabilised inpatients with schizophrenia. METHODS:Executive functions using an extensive battery constituted of several tests as well as psychopathology were assessed in 38 inpatients with a DSM-IV diagnosis of...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546800444000308

    authors: Simon AE,Berger GE,Giacomini V,Ferrero F,Mohr S

    更新日期:2006-09-01 00:00:00

  • Association between cognitive impairment and cardiovascular burden in patients with severe mental disorder.

    abstract::Introduction: Cognitive impairment is related to an increase in cardiovascular risk (CVR) in the general population. However, in severe mental disorder (SMD), the evidence is less consistent. Few studies have evaluated the relationship between cognition and vascular burden in SMD. This study determines the relationshi...

    journal_title:Cognitive neuropsychiatry

    pub_type: 杂志文章

    doi:10.1080/13546805.2019.1676709

    authors: Foguet-Boreu Q,Guàrdia Sancho A,Santos Lopez JM,Roura Poch P,Palmarola Ginesta J,Puig-Ribera AM,Muñoz Pradós J

    更新日期:2020-01-01 00:00:00