Latent inhibition, learned irrelevance, and schizotypy: assessing their relationship.

Abstract:

INTRODUCTION:Previous research suggests that latent inhibition is reduced in patients with acute schizophrenia and in healthy participants with high levels of schizotypic characteristics. Other evidence indicates the disruption of a related effect (learned irrelevance) in patients with acute schizophrenia. METHOD:This study used a recently developed latent inhibition procedure, that avoids methodological limitations of previous studies, and a related learned irrelevance procedure to assess the relationship between these phenomena and schizotypic characteristics in undergraduate participants. RESULTS:Participants preexposed to a letter (S) learnt the predictive relationship between that letter and another letter (X) slower than the relationship between a novel letter and X (a latent inhibition effect). Experiment 1 found reduced latent inhibition in the high schizotypy group after 10, but not 20 preexposures. In Experiment 2, participants preexposed to both S and X learnt a subsequent relationship between them slower than the relationship between a novel letter and X (a learned irrelevance effect). This effect was abolished in participants with high levels of schizotypy. CONCLUSIONS:These results are both the first demonstration of abolished learned irrelevance and of a significant reduction in latent inhibition without employing an explicit masking task in participants with high levels of positive schizotypy.

journal_name

Cogn Neuropsychiatry

authors

Schmidt-Hansen M,Killcross AS,Honey RC

doi

10.1080/13546800802664539

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

11-29

issue

1

eissn

1354-6805

issn

1464-0619

pii

908692888

journal_volume

14

pub_type

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