Abstract:
INTRODUCTION:We have previously reported that people with schizophrenia and formal thought disorder (FTD) were disproportionately impaired in recalling sentences verbatim and in judging their plausibility. We proposed that these deficits were due to impairment in integrating higher-order semantic information to construct a global whole. However, it is also possible that a lower-level linguistic problem affecting lexical activation could account for this pattern. METHODS:The present study analysed and compared the sentence repetition errors produced by people with FTD, people with schizophrenia who were non-FTD and healthy controls. Errors due to failure of activation of the target lexical items were differentiated from those due to erroneous integration of information. RESULTS:People with FTD produced significantly more unrelated lexical substitutions and omissions in their corpora than the other two groups, indicating an impairment of activation. In addition, they made significantly more erroneous contextual inferences and unrelated references, suggesting they were impaired in reconstructing the global whole from successfully activated items. CONCLUSION:These findings are consistent with a dual process account of impairments in FTD. Difficulties in repeating and judging sentence acceptability arises due to a combination of difficulty with activation and deficits in using linguistic context to process and produce speech. It is suggested that processing difficulties in FTD result from an impairment in using semantic context to drive lexical access and construction of a global whole.
journal_name
Cogn Neuropsychiatryjournal_title
Cognitive neuropsychiatryauthors
Dwyer K,Peters E,McKenna P,David A,McCarthy Rdoi
10.1080/13546805.2013.870069subject
Has Abstractpub_date
2014-01-01 00:00:00pages
337-58issue
4eissn
1354-6805issn
1464-0619journal_volume
19pub_type
杂志文章abstract:INTRODUCTION:Most evidence suggests that schizophrenia is associated with pervasive prospective memory (PM) impairment that does not vary as a function of task demands. However, a central tenet of the Multiprocess Framework is that PM involves both automatic and strategic processes, and that their relative prominence v...
journal_title:Cognitive neuropsychiatry
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