Abstract:
INTRODUCTION:It has been suggested that the positive symptoms of acute schizophrenia are a consequence of a disruption of the process that produces latent inhibition (slower acquisition of conditioned responding after preexposure to the conditioned stimulus) and that this effect can be modelled by pro- and antipsychotic compounds in healthy participants and in nonhuman animals. This idea assumes that latent inhibition in humans and animals is underpinned by the same process(es). METHOD:First, we question the equivalence of human and animal latent inhibition. Second, we review the studies that have examined latent inhibition in populations with schizophrenia and in healthy populations after administration of amphetamine or haloperidol. RESULTS:Theoretical analysis of the similarities and differences in latent inhibition effects, and the procedures used to generate them, in humans and animals renders the suggested equivalence between them unconvincing. The studies examining latent inhibition in populations with schizophrenia and in healthy populations after administration of amphetamine or haloperidol are marked by a number of methodological shortcomings and reveal discrepant results. CONCLUSIONS:The theoretical and empirical analyses provide little support for a common process underlying deficits of latent inhibition in patients exhibiting positive symptoms of acute schizophrenia, and such deficits in experimental models in healthy humans and infrahumans.
journal_name
Cogn Neuropsychiatryjournal_title
Cognitive neuropsychiatryauthors
Schmidt-Hansen M,Le Pelley Mdoi
10.1080/13546805.2012.667202subject
Has Abstractpub_date
2012-11-01 00:00:00pages
473-505issue
6eissn
1354-6805issn
1464-0619journal_volume
17pub_type
杂志文章,评审abstract::Self-recognition and self-awareness are processes fundamental to human development. This report describes the case of an 80-year-old woman who demonstrated the ''mirror sign'', an inability to recognise the reflection of oneself in a mirror. An attempt has been made to provide a cognitive neuropsychological explanatio...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/135468096396613
更新日期:1996-05-01 00:00:00
abstract:INTRODUCTION:Cognitive neuropsychiatry has had much success in providing theoretical models for the causal origins of many delusional beliefs. Recently, it has been suggested that some anorexia nervosa patients' beliefs about their own body size should be considered delusions. As such, it seems high time the methods of...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2017.1401531
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Previous research has suggested that biases in cognitive processes involved in everyday reasoning may contribute to the development of delusional beliefs. The aim of this study was to explore jumping to conclusions (JTC), a data-gathering bias, and jumping to perceptions (JTP), a bias towards believing amb...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800903495684
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Abnormalities in associative frontostriatal circuits are often associated with obsessive-compulsive disorder (OCD), leading many researchers to predict that executive dysfunction should be particularly pronounced. However, deficits on putative tests of this construct have not consistently been identified. ...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1080/13546800444000227
更新日期:2006-03-01 00:00:00
abstract:INTRODUCTION:We have previously reported that people with schizophrenia and formal thought disorder (FTD) were disproportionately impaired in recalling sentences verbatim and in judging their plausibility. We proposed that these deficits were due to impairment in integrating higher-order semantic information to constru...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2013.870069
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Psychomotor slowing is an important feature of schizophrenia and the relation with negative symptoms is not fully understood. This study aims, first, to investigate the association between negative symptoms and psychomotor slowing. Second, we want to investigate whether fine motor slowing reflects clinical...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2013.779578
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Research on empathy has a long tradition in clinical research, as deficits in empathy have been found in many mental disorders. Over decades, a large amount of measures for empathy have been developed, but in many cases these have not been analysed with respect to validity. Therefore, this paper aims to re...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2014.991781
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:A sample of everyday difficulties was collected, encompassing errors and unusual experiences participants had encountered when recognising their own faces in everyday life, with the aim of characterising similarities and differences between the reported difficulties and the major forms of self-recognition ...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800344000075
更新日期:2004-08-01 00:00:00
abstract:INTRODUCTION:There is substantial evidence that patients with schizophrenia present with impaired Theory of Mind (ToM). Whereas previous studies have focused on general ToM abilities, the present study is aimed at testing the underlying behavioural and neurocognitive mechanisms of the impaired integration of affective ...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800802490034
更新日期:2008-11-01 00:00:00
abstract:INTRODUCTION:Category fluency is associated with speed-, executive- and semantic impairments in schizphrenia. It has traditionally been linked to negative symptoms, whereas the relation to positive symptoms is mixed. Associations to the consensus negative, positive and disorganisation factors have not been analysed bef...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1080/13546805.2017.1418306
更新日期:2018-01-01 00:00:00
abstract::Numerous genes modulate dopamine and consequently prefrontal cortical function. Some of these genes - notably catechol-O-methyltransferase - have been shown to impact a variety of core cognitive processes that are dependent upon the prefrontal cortex. This demonstration that a single functional polymorphism can contri...
journal_title:Cognitive neuropsychiatry
pub_type:
doi:10.1080/13546800903126016
更新日期:2009-01-01 00:00:00
abstract::Introduction: Cognitive impairment is related to an increase in cardiovascular risk (CVR) in the general population. However, in severe mental disorder (SMD), the evidence is less consistent. Few studies have evaluated the relationship between cognition and vascular burden in SMD. This study determines the relationshi...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2019.1676709
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:It is assumed that people spontaneously evaluate any incoming stimulus as pleasant or unpleasant. The evaluative response appears to structure perception and to have direct links to emotional states. METHODS:To investigate the automatic processing of face valence a sequential priming task based on emotion...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800344000318
更新日期:2005-01-01 00:00:00
abstract::Confabulations and delusions both involve the production of false claims. Although they may have different types of content, they share several characteristics. For example, they are often held with considerable conviction and are resistant to counter evidence, they may be acted upon, and they may be accompanied by a ...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章,评审
doi:10.1080/13546800903441902
更新日期:2010-01-01 00:00:00
abstract::Background: Jumping to conclusions (JTC) and overconfidence in errors are well established in individuals with a liability to psychosis. Experimental research suggests that subjecting individuals to dilemmas and doubt prompts a subsequent hardening of attitudes and may foster delusion-like convictions. For the present...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1080/13546805.2019.1642863
更新日期:2019-07-01 00:00:00
abstract::Numerous studies have suggested, via the interpretation of the negative priming effect as a measure of cognitive inhibition, that schizotypal subjects are less able to inhibit irrelevant distracting information. Recent research has revealed, however, that negative priming effects can be caused by two quite different p...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/135468097396423
更新日期:1997-02-01 00:00:00
abstract:INTRODUCTION:Little is known about the relationship between cognitive dysfunction and functional disability in alcohol dependence with comorbid affective disorders. We investigated the neuropsychology of alcohol dependence in detoxified adults with and without affective comorbidity and examined the factors associated w...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2015.1014031
更新日期:2015-01-01 00:00:00
abstract::Bipolar disorder is characterised by affective instability and mood dysregulation. Understanding of the neural mechanism underlying this remains limited, however. Here, findings will be described from studies that have employed neuroimaging techniques to measure neural responses to emotionally salient stimuli in indiv...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章,评审
doi:10.1080/13546800444000290
更新日期:2006-05-01 00:00:00
abstract::Introduction: Studies have documented both executive functions (EF) impairment in children with Attention Deficit / Hyperactivity Disorders (ADHD) and Theory of Mind (ToM), yielding mixed results, possibly because of a variety of tasks used, all requiring different levels of language skills.Aim: To investigate the rel...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2019.1681951
更新日期:2020-01-01 00:00:00
abstract::Patients with Gilles de la Tourette syndrome (TS) frequently show obsessions and compulsions. Pathophysiologically, TS has been linked to abnormalities of the basal ganglia and forebrain which are related to emotional processes. Because recordings of event-related potentials (ERPs) have shown that the emotional conten...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/135468099396052
更新日期:1999-02-01 00:00:00
abstract::Introduction: Auditory verbal hallucinations (AVH) are a core symptom of psychotic disorders such as schizophrenia but are also reported in 10-15% of the general population. Impairments in self-voice recognition are frequently reported in schizophrenia and associated with the severity of AVH, particularly when the sel...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2019.1621159
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:Visual scanning is widely reported to be abnormal in schizophrenia. The majority of eye movement studies in schizophrenic patients have used pictures of a face in isolation in free viewings. This study was designed to examine whether attentional control, through instructions, modulates the visuomotor behav...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2012.683245
更新日期:2013-05-01 00:00:00
abstract::In order to ask whether autism is associated with difficulty in self-monitoring we gave a group of children and adolescents with autism a task in which they themselves had to remember whether they or another person had performed certain actions. In our first experiment, three groups of participants had to recall wheth...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/135468099395855
更新日期:1999-11-01 00:00:00
abstract::Although schizophrenic patients, as a group, show deficits on measures of explicit learning, it is unclear whether they also have deficits on measures of implicit learning. The current study assessed procedural learning in a sample of 48 chronic schizophrenic inpatients and 23 normal controls using the serial reaction...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/135468097396360
更新日期:1997-05-01 00:00:00
abstract:INTRODUCTION:Alteration of empathy is common in patients with psychiatric disorders. Reliable and valid assessment tools for measuring empathy of clinical samples is needed. The Questionnaire of Cognitive and Affective Empathy (QCAE) is a newly-developed instrument to capture cognitive and affective components of empat...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2020.1846025
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION:Patients with schizophrenia show impairments in working-memory and visual-spatial processing, but little is known about the dynamic interplay between the two. To provide insight into this important question, we examined the effect of positive and negative symptom expressions in healthy adults on perceptual...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2016.1206873
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Recent reports of lexical-semantic deficits in patients with schizophrenia (Laws, Al-Uzri, & Mortimer, 2000; Laws, McKenna, & Kondel, 1998) suggest that younger patients have problems accessing intact memories and older patients show apparent "loss" of the lexical-semantic memory representations themselves...
journal_title:Cognitive neuropsychiatry
pub_type: 临床试验,杂志文章
doi:10.1080/13546800444000137
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Substance abuse is highly prevalent in schizophrenia and it has been associated with negative consequences on the course of the pathology. Regarding cognition, the prevailing literature has produced mixed results. Some groups have reported greater cognitive impairments in dual diagnosis schizophrenia, while ...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800802264330
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:Cognitive impairment is a pervasive feature of schizophrenia, and is a major determinant of the functional disability that is characteristic of the disorder. However, research investigating whether patients with schizophrenia show a deficit awareness remains unclear. The present study aimed to replicate an...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546805.2014.909311
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Memory for public and autobiographical events was investigated in people diagnosed with depression, schizophrenia, and a group of healthy controls. The aim was to determine whether the overgeneral memory effect emerged in clinical conditions other than depression and in memory domains other than autobiogra...
journal_title:Cognitive neuropsychiatry
pub_type: 杂志文章
doi:10.1080/13546800601066142
更新日期:2007-07-01 00:00:00