Abstract:
PURPOSE OF REVIEW:Although available therapies can effectively inhibit hepatitis B virus (HBV) replication in patients with active chronic hepatitis B (CHB) infection, therapeutic efficacy is limited because of potential drug resistance, and an inability to mediate viral clearance and to rectify immune impairment in CHB patients. This review will summarize the state-of-the-art for anti-HBV drugs and focus on potential drugs and targets under development and evaluation. RECENT FINDINGS:New developing drugs are evaluated for their antiviral effects in the areas of interference with the viral replication cycle, elimination of covalently closed circular DNA, modulation of host immunity and identification of the La protein and its regulator casein kinase as possible targets for the development of anti-HBV therapies. SUMMARY:These novel compounds and targets have showed great inhibitory effects on HBV replication in vitro and in animal models. Several novel therapies are promising in early clinical trials. Potentially, combination of newly developing and current antiviral drugs may cure CHB in the clinic.
journal_name
Curr Opin Infect Disjournal_title
Current opinion in infectious diseasesauthors
Pan J,Tong S,Kang L,Tang Jdoi
10.1097/QCO.0000000000000318subject
Has Abstractpub_date
2016-12-01 00:00:00pages
632-638issue
6eissn
0951-7375issn
1473-6527pii
00001432-201612000-00012journal_volume
29pub_type
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000092
更新日期:2014-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
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doi:10.1097/QCO.0b013e328334e54d
更新日期:2010-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
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更新日期:2014-04-01 00:00:00