Experimental infections with West Nile virus.

Abstract:

PURPOSE OF REVIEW:West Nile virus emerged recently in North America as a serious human and animal pathogen. This review summarizes the use of experimental infections with West Nile virus in diverse vertebrate species that have been used to answer fundamental questions about the host response, pathogenesis of West Nile virus infection and virus evolution. RECENT FINDINGS:West Nile virus has an extremely broad vertebrate host range. Infection of common species of birds has defined those with high vs. low potential to serve as amplifying hosts for the virus. In general, mammals (primates, horses, companion animals) are dead-end hosts for West Nile virus, although some circumstances (i.e. immunosuppression) may allow individuals to become capable of transmitting the virus to mosquitoes. Some mammals (rodents, rabbits, squirrels) and reptiles (alligators) have been found to develop a viremia of sufficient magnitude to predict at least low competence for infecting feeding mosquitoes. Finally, experimental infection of rodents, horses and primates with West Nile virus has been integral to developing and evaluating the efficacy of West Nile virus vaccines. SUMMARY:Experimental infection with West Nile virus has assisted in delineating those hosts important and not important to the transmission cycle, in understanding how the virus induces disease in susceptible hosts, and in validating the efficacy of vaccines used for control of disease.

journal_name

Curr Opin Infect Dis

authors

Bowen RA,Nemeth NM

doi

10.1097/QCO.0b013e32816b5cad

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

293-7

issue

3

eissn

0951-7375

issn

1473-6527

pii

00001432-200706000-00010

journal_volume

20

pub_type

杂志文章,评审
  • Viruses causing childhood diarrhoea in the developing world.

    abstract:PURPOSE OF REVIEW:Acute gastroenteritis is one of the leading causes of morbidity and mortality in children in the developing world. With improvements in hygiene and sanitation, the burden of disease due to bacterial and parasitic infections has decreased and an increasing proportion of diarrhoea hospitalizations are a...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328330662f

    authors: Ramani S,Kang G

    更新日期:2009-10-01 00:00:00

  • Advances in antimicrobial therapy of community-acquired pneumonia.

    abstract::Community-acquired pneumonia has a significant impact upon healthcare in North America and worldwide. In the U.S. it is responsible for three to four million cases yearly and 78,000 deaths. It is not a homogeneous entity and it may be caused by a number of pathogens including Streptococcus pneumoniae, the atypicals (M...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199904000-00006

    authors: Mandell LA

    更新日期:1999-04-01 00:00:00

  • Bronchiectasis: new findings in the pathogenesis and treatment of this disease.

    abstract:PURPOSE OF REVIEW:Bronchiectasis is an under-appreciated cause of chronic lung disease in the USA. We highlight developments in diagnosis and treatment of this debilitating disease. RECENT FINDINGS:A possible link between gastroesophageal reflux and development of nontuberculous mycobacterial lung disease was highligh...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3282f4f237

    authors: Ilowite J,Spiegler P,Chawla S

    更新日期:2008-04-01 00:00:00

  • Enteric fever: a travel medicine oriented view.

    abstract:PURPOSE OF REVIEW:Enteric fever continues to be an important infection among populations in endemic countries and among travelers to these areas. This review aims to describe recent epidemiological trends and developments in diagnosis, treatment and prevention. RECENT FINDINGS:Data indicate that the burden of enteric ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32833c7ca1

    authors: Meltzer E,Schwartz E

    更新日期:2010-10-01 00:00:00

  • Therapy for pneumococcal bacteremia: monotherapy or combination therapy?

    abstract:PURPOSE OF REVIEW:The issue of whether the outcome of bacteremic pneumococcal infections is improved with the use of combination antibiotic therapy versus monotherapy is still not resolved. This review highlights recent studies that have addressed this issue. RECENT FINDINGS:Some studies have indicated benefit of comb...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283232a30

    authors: Feldman C,Anderson R

    更新日期:2009-04-01 00:00:00

  • New developments in epidemiology, diagnosis, and treatment of fascioliasis.

    abstract:PURPOSE OF REVIEW:This review focuses on the recent developments in the epidemiology, burden of disease, diagnostic tests, and treatment of fascioliasis. RECENT FINDINGS:Recent epidemiologic data suggest that either the endemic areas are expanding or disease is being recognized in areas where it was not previously obs...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283567b7e

    authors: Cabada MM,White AC Jr

    更新日期:2012-10-01 00:00:00

  • New approaches to prevention of staphylococcal infection in surgery.

    abstract:PURPOSE OF REVIEW:The present review describes the literature about the prevention of Staphylococcus aureus infections in surgery, published from August 2006 to January 2008, and puts it into perspective. RECENT FINDINGS:To prevent Staphylococcus aureus infections after surgical procedures, three methods were describe...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328301391d

    authors: van Rijen MM,Kluytmans JA

    更新日期:2008-08-01 00:00:00

  • Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients.

    abstract:PURPOSE OF REVIEW:New respiratory viruses have been discovered in recent years and new molecular diagnostic assays have been developed that improve our understanding of respiratory virus infections. This article will review the changing epidemiology of these viruses after hematopoietic stem cell and solid organ transpl...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283480440

    authors: Renaud C,Campbell AP

    更新日期:2011-08-01 00:00:00

  • Two drugs regimens for HIV.

    abstract:PURPOSE OF REVIEW:As the evidence for two-drug regimens (2DR) for HIV treatment accumulates and 2DR start to enter consensus guidelines, this review covers the history, rationale and current evidence for 2DR in first-line and switch settings. RECENT FINDINGS:Until recently, most evidence for 2DR was for boosted protea...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000615

    authors: Waters L,Church H

    更新日期:2020-02-01 00:00:00

  • The novel applications of the quantitative analysis of neutrophil cell surface FcgammaRI (CD64) to the diagnosis of infectious and inflammatory diseases.

    abstract:PURPOSE OF REVIEW:Several studies show that the number of FcgammaRI (CD64) on the surface of neutrophils increases in infections. However, in spite of increased research interest in recent years, there is no clear general view on the usability of neutrophil FcgammaRI in clinical infection diagnostics. This review tries...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32833939b0

    authors: Nuutila J

    更新日期:2010-06-01 00:00:00

  • Risk stratification for multidrug-resistant Gram-negative infections in ICU patients.

    abstract:PURPOSE OF REVIEW:Antimicrobial resistance among Gram-negative microorganisms has alarmingly increased in the past 10 years worldwide. Infections caused by these microorganisms are difficult to treat, especially in critically ill patients.The present review examines how to accurately predict which patients carry a grea...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000599

    authors: Burillo A,Muñoz P,Bouza E

    更新日期:2019-12-01 00:00:00

  • Optimizing dosing of antibiotics in critically ill patients.

    abstract:PURPOSE OF REVIEW:Recent studies suggest that contemporary antibiotic dosing is unlikely to achieve best outcomes for critically ill patients because of extensive pharmacokinetic variability and altered pharmacodynamics. Dose adaptation is considered quite challenging because of unpredictable dose-exposure relationship...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000206

    authors: Parker SL,Sime FB,Roberts JA

    更新日期:2015-12-01 00:00:00

  • Urinary tract infection in diabetes.

    abstract:PURPOSE OF REVIEW:The aim of this article is to review recent publications relevant to understanding the interaction of urinary tract infection and diabetes mellitus, including epidemiology, pathogenesis, microbiology, and treatment. RECENT FINDINGS:The largest number of identified reports described aspects of epidemi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200502000-00009

    authors: Nicolle LE

    更新日期:2005-02-01 00:00:00

  • Parasitic infections of the intestine.

    abstract::Intestinal protozoal infections cause significant disease not only in the tropics but also in immunocompromised hosts and returning travellers in the developed world. Precise diagnosis of protozoal intestinal infection by microscopy can be difficult. Enzyme immunoassays for antigen detection are being used for some pr...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200110000-00013

    authors: Schuster H,Chiodini PL

    更新日期:2001-10-01 00:00:00

  • Travel-associated zoonotic bacterial diseases.

    abstract:PURPOSE OF REVIEW:Bacterial zoonoses are increasingly described in association with travel. Some bacterial zoonoses constitute important causes of post-travel illness. We focus on leptospirosis and rickettsiosis - the most common travel-associated bacterial zoonoses. RECENT FINDINGS:Leptospirosis is regarded to be the...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32834a1bd2

    authors: Leshem E,Meltzer E,Schwartz E

    更新日期:2011-10-01 00:00:00

  • Polyclonal and monoclonal antibodies for the treatment of influenza.

    abstract:PURPOSE OF REVIEW:This review summarizes past and ongoing efforts for using polyclonal and monoclonal antibodies for the treatment of influenza, and is focused on products that have entered clinical trials. RECENT FINDINGS:At least three polyclonal and eight monoclonal antibody products have been tested in clinical tr...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000499

    authors: Beigel JH

    更新日期:2018-12-01 00:00:00

  • Mind the gaps: challenges in the clinical management of invasive candidiasis in critically ill patients.

    abstract:PURPOSE OF REVIEW:Strict adherence to clinical practice guidelines is recognized to improve outcomes but the inconvenient truth is that only a small subset of what is done in medicine has been tested in appropriate, well designed studies. In this article, we aim to review controversial aspects of the clinical managemen...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000684

    authors: Peçanha-Pietrobom PM,Colombo AL

    更新日期:2020-12-01 00:00:00

  • Emerging clinical issues in refugees.

    abstract:PURPOSE OF REVIEW:The world's population is becoming increasing mobile. Each mobile population (e.g. immigrants, refugees, travelers) has certain characteristics that determine public health risk and infectious disease burden. Refugees present unique challenges to public health officials and infectious disease speciali...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32832f14a4

    authors: Stauffer WM,Weinberg M

    更新日期:2009-10-01 00:00:00

  • Current thinking on genital herpes.

    abstract:PURPOSE OF REVIEW:Genital herpes has a high global prevalence and burden of disease. This manuscript highlights recent advances in our understanding of genital herpes simplex virus (HSV) infections. RECENT FINDINGS:Studies demonstrate a changing epidemiological landscape with an increasing proportion of genital herpes...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000029

    authors: Hofstetter AM,Rosenthal SL,Stanberry LR

    更新日期:2014-02-01 00:00:00

  • Infectious keratitis.

    abstract:PURPOSE OF REVIEW:Infectious keratitis is a medical emergency. Improper management can lead to marked loss of vision. This review identifies recent trends in the study of infectious keratitis. RECENT FINDINGS:A multicountry outbreak of Fusarium keratitis emphasizes that contact lens wear is a major risk factor for inf...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328017f878

    authors: Thomas PA,Geraldine P

    更新日期:2007-04-01 00:00:00

  • Effect of major abdominal surgery on the host immune response to infection.

    abstract:PURPOSE OF REVIEW:The present review summarizes key studies on the effects of major abdominal surgery on the host response to infection published during the last 18 months. RECENT FINDINGS:Surgical trauma causes stereotyped systemic proinflammatory and compensatory anti-inflammatory reactions. It is leukocyte reprogra...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32833939cb

    authors: Buttenschoen K,Fathimani K,Buttenschoen DC

    更新日期:2010-06-01 00:00:00

  • Autoimmunity and HIV.

    abstract:PURPOSE OF REVIEW:This review focuses on some of the recent advances in the understanding of HIV immunopathogenesis and the diagnosis and treatment of several autoimmune conditions associated with HIV in the era of potent antiretroviral therapy. RECENT FINDINGS:Chronic immune activation with progressive immune exhaust...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283210006

    authors: Stratton R,Slapak G,Mahungu T,Kinloch-de Loes S

    更新日期:2009-02-01 00:00:00

  • New drugs and treatment for cryptosporidiosis.

    abstract:PURPOSE OF REVIEW:There is a history of inadequate treatments for cryptosporidiosis and a lack of understanding of the species that cause human disease. Against this background, we review the efficacy of antiparasitic agents, particularly nitazoxanide, which has led to increased treatment options, the potential for imm...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200412000-00008

    authors: Smith HV,Corcoran GD

    更新日期:2004-12-01 00:00:00

  • Dolutegravir resistance mutations: lessons from monotherapy studies.

    abstract:PURPOSE OF REVIEW:Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (InSTI) with an outstanding antiviral potency, good tolerability, good pharmacokinetic profile with a lack of major drug-drug interactions, and a barrier to resistance higher than the other compounds of the class (raltegravi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000453

    authors: Blanco JL,Marcelin AG,Katlama C,Martinez E

    更新日期:2018-06-01 00:00:00

  • Methods of assessing body shape and composition in HIV-associated lipodystrophy.

    abstract::Although HIV-associated lipodystrophy can be diagnosed just from clinical examination, criteria for diagnosis and judgement of severity are not clearly defined. Clinical assessment can be systematized with questionnaires for patients and physicians. Computed tomography, nuclear magnetic imaging and dual-energy X-ray a...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200202000-00003

    authors: Schwenk A

    更新日期:2002-02-01 00:00:00

  • Update on nonantibiotic therapies for acute gastroenteritis.

    abstract:PURPOSE OF REVIEW:The aim of this review is to provide an update of nonantibiotic therapies for acute gastroenteritis (AGE), focusing on antiemetics and probiotics. RECENT FINDINGS:The mainstay of therapy for nonsevere AGE remains oral rehydration therapy (ORT). Recent randomized controlled trials and metaanalyses hav...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000670

    authors: Funk A,Schnadower D,Freedman SB

    更新日期:2020-10-01 00:00:00

  • Risk of invasive fungal infections during hospital construction: how to minimize its impact in immunocompromised patients.

    abstract:PURPOSE OF REVIEW:Fungal outbreaks have been reported in healthcare settings, showing that construction activities are a serious threat to immunocompromised hosts. Preventive measures to control fungal outbreaks (especially Aspergillus spp.) are considered essential during hospital construction. In this article, we upd...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000566

    authors: Alvarez-Moreno CA,Combariza JF

    更新日期:2019-08-01 00:00:00

  • Sexual networks and sexually transmitted infections: innovations and findings.

    abstract:PURPOSE OF REVIEW:With increasing recognition of the importance of sexual networks in the dissemination of sexually transmitted infections (STIs), research is expanding. This review focuses on methodology for conducting sexual network research with in-depth presentations of recent and novel studies conducted on four co...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283422647

    authors: Doherty IA

    更新日期:2011-02-01 00:00:00

  • Impact of diagnostic markers on early antifungal therapy.

    abstract:PURPOSE OF REVIEW:The early treatment of invasive fungal infection is critical but is hampered by the non-specific nature of clinical and radiological signs and the insensitivity of current laboratory diagnostic methods. If mortality due to invasive fungal infection is to be reduced, new, preemptive therapeutic strateg...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200312000-00002

    authors: Jones BL,McLintock LA

    更新日期:2003-12-01 00:00:00

  • Toxoplasma prophylaxis in haematopoietic cell transplant recipients: a review of the literature and recommendations.

    abstract:PURPOSE OF REVIEW:Toxoplasmosis in haematopoietic cell transplant (HCT) recipients is associated with high morbidity and mortality rates. Prophylaxis following HCT is recommended for high-risk pre-HCT toxoplasma-seropositive (pre-HCTSP) recipients. However, there is no agreement or consistency among programmes on wheth...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000169

    authors: Gajurel K,Dhakal R,Montoya JG

    更新日期:2015-08-01 00:00:00