Hidradenitis suppurativa: a review of cause and treatment.

Abstract:

PURPOSE OF REVIEW:Hidradenitis suppurativa is a chronic or relapsing inflammatory cutaneous disorder manifested by recurrent formation of abscesses, fistulating sinus and scarring in the apocrine-gland-bearing skin. This review discusses the different aetiological theories and management opportunities. RECENT FINDINGS:Current understanding of the pathogenesis suggests that hyperkeratosis of the infundibulum, leading to follicular occlusion of the pilosebaceous unit plays a role. Bacterial infection with staphylococci, Escherichia coli and streptococcus is considered as a secondary event in the pathogenesis. Smoking and obesity are both known as risk factors and are associated with more severe disease course. Recently, more attention has been put into the understanding of the immunopathology of the skin and the results indicate that hidradenitis suppurativa may be considered as an inflammatory disease of unknown cause based on a defect in the hair follicle immunity. The treatments are most appropriately chosen on the basis of disease severity and the existence of any associated risk factors or comorbidities. There are three levels in the management of hidradenitis suppurativa: topical options, systemic options and surgical methods including laser therapy. At each level several treatment principles have shown themselves to be efficient, and may therefore be used either alone or in combination. Therapies are generally effective against microorganisms, inflammation or infundibular hyperkeratosis. Where an antimicrobial therapy is used, the drugs used often have significant additional immunomodulatory effects. SUMMARY:The recent studies give us a better insight into the pathogenesis of hidradenitis suppurativa and should translate into improved therapies.

journal_name

Curr Opin Infect Dis

authors

Yazdanyar S,Jemec GB

doi

10.1097/QCO.0b013e3283428d07

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

118-23

issue

2

eissn

0951-7375

issn

1473-6527

journal_volume

24

pub_type

杂志文章,评审
  • Travel-associated zoonotic bacterial diseases.

    abstract:PURPOSE OF REVIEW:Bacterial zoonoses are increasingly described in association with travel. Some bacterial zoonoses constitute important causes of post-travel illness. We focus on leptospirosis and rickettsiosis - the most common travel-associated bacterial zoonoses. RECENT FINDINGS:Leptospirosis is regarded to be the...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32834a1bd2

    authors: Leshem E,Meltzer E,Schwartz E

    更新日期:2011-10-01 00:00:00

  • Fungal infections in bone marrow transplant patients.

    abstract:PURPOSE OF REVIEW:Invasive fungal infections have become the leading infectious cause of death in recipients of hematopoietic cell transplantation. Several factors have led to a renaissance in the study of invasive fungal infections. The growing incidence of both commonly encountered as well as emerging pathogens and t...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000136935.13662.af

    authors: Brown JM

    更新日期:2004-08-01 00:00:00

  • Mass drug administration and the global control of schistosomiasis: successes, limitations and clinical outcomes.

    abstract:PURPOSE OF REVIEW:Preventive chemotherapy is advocated for the global control and elimination of schistosomiasis. Despite the well known short-term benefits of treating patients for schistosomiasis, the impact of mass drug administration (MDA) campaigns to control the disease in the long term remains unresolved. RECEN...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000312

    authors: Olveda DU,McManus DP,Ross AG

    更新日期:2016-12-01 00:00:00

  • Probiotics and neonatal intestinal infection.

    abstract:PURPOSE OF REVIEW:Necrotizing enterocolitis remains an enigmatic and potentially devastating condition with high morbidity and mortality. This review explores ways in which bacterial pathogens, together with gut microflora, influence the pathophysiology of necrotizing enterocolitis. Specifically, it examines the role o...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000224823.73223.29

    authors: Hammerman C,Kaplan M

    更新日期:2006-06-01 00:00:00

  • The company malaria keeps: how co-infection with Epstein-Barr virus leads to endemic Burkitt lymphoma.

    abstract:PURPOSE OF REVIEW:Co-infection with Plasmodium falciparum malaria and Epstein-Barr virus (EBV) are implicated in the cause of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in equatorial Africa. Although the causal association between EBV and eBL has been established, P. falciparum malaria's role i...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328349ac4f

    authors: Moormann AM,Snider CJ,Chelimo K

    更新日期:2011-10-01 00:00:00

  • Carbapenem use in critically ill patients.

    abstract:PURPOSE OF REVIEW:To review available data on carbapenem use in ICU. Carbapenem is a broad spectrum well tolerated antibiotic family that keep an excellent activity to extended spectrum β-lactamases and AmpC hyperproducer and in susceptible Pseudomonas aeruginosa and Acinetobacter baumannii. It becomes a drug of choice...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000622

    authors: Patrier J,Timsit JF

    更新日期:2020-02-01 00:00:00

  • Parasitic infections of the intestine.

    abstract::Intestinal protozoal infections cause significant disease not only in the tropics but also in immunocompromised hosts and returning travellers in the developed world. Precise diagnosis of protozoal intestinal infection by microscopy can be difficult. Enzyme immunoassays for antigen detection are being used for some pr...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200110000-00013

    authors: Schuster H,Chiodini PL

    更新日期:2001-10-01 00:00:00

  • Sexual networks and sexually transmitted infections: innovations and findings.

    abstract:PURPOSE OF REVIEW:With increasing recognition of the importance of sexual networks in the dissemination of sexually transmitted infections (STIs), research is expanding. This review focuses on methodology for conducting sexual network research with in-depth presentations of recent and novel studies conducted on four co...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283422647

    authors: Doherty IA

    更新日期:2011-02-01 00:00:00

  • HIV-1 subtypes: epidemiology and significance for HIV management.

    abstract:PURPOSE OF REVIEW:This review presents an update on the molecular epidemic patterns of HIV-1 infection and the effects of subtype-related genetic variability on transmission, disease progression, response to antiretroviral therapy and drug-resistance pathways. RECENT FINDINGS:The molecular epidemiology of HIV-1 infect...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000200293.45532.68

    authors: Geretti AM

    更新日期:2006-02-01 00:00:00

  • The changing spectrum of candidemia in oncology patients: therapeutic implications.

    abstract::Infections caused by Candida spp. are frequent and serious in oncology patients. Over the past decade, the introduction of azole antifungals as prophylactic agents, and other factors have caused a shift in the species of Candida that cause infection. During the period under review (June 1999 to June 2000), several stu...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-200012000-00006

    authors: Marr KA

    更新日期:2000-12-01 00:00:00

  • Drug combinations for visceral leishmaniasis.

    abstract:PURPOSE OF REVIEW:Several attempts have been made to combine drugs for treating visceral leishmaniasis, but only recently have effective drugs become available and combinations been tested systematically. RECENT FINDINGS:Sequential treatments with liposomal amphotericin B followed by miltefosine or paromomycin (as sho...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32833fca9d

    authors: Olliaro PL

    更新日期:2010-12-01 00:00:00

  • Rotavirus vaccines.

    abstract::The past few years have seen important developments in understanding the epidemiological and virological characteristics of rotaviruses, and rapid progress has been made in rotavirus vaccine development, but further challenges remain before a vaccine is introduced into widespread use. The licensure of the first rotavi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-200010000-00011

    authors: Lynch M,Bresee JS,Gentsch JR,Glass RI

    更新日期:2000-10-01 00:00:00

  • Genitourinary pathogens and preterm birth.

    abstract:PURPOSE OF REVIEW:The aim is to describe and quantify the association between genitourinary tract infections and preterm birth. RECENT FINDINGS:Recent studies confirm the importance of identifying and treating both asymptomatic and symptomatic bacteriuria in pregnancy, which is reflected in current antenatal screening...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328360dc31

    authors: Cunnington M,Kortsalioudaki C,Heath P

    更新日期:2013-06-01 00:00:00

  • Malaria.

    abstract:PURPOSE OF REVIEW:This review addresses recent developments that relate to the pathogenesis of severe malaria and its treatment, and also highlights the increase in the global burden of malaria and provides a summary of clinical trials of malaria vaccines. RECENT FINDINGS:Malaria, one of the world's most important par...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200310000-00004

    authors: Maitland K,Bejon P,Newton CR

    更新日期:2003-10-01 00:00:00

  • Emerging clinical issues in refugees.

    abstract:PURPOSE OF REVIEW:The world's population is becoming increasing mobile. Each mobile population (e.g. immigrants, refugees, travelers) has certain characteristics that determine public health risk and infectious disease burden. Refugees present unique challenges to public health officials and infectious disease speciali...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32832f14a4

    authors: Stauffer WM,Weinberg M

    更新日期:2009-10-01 00:00:00

  • Paramyxovirus infections in hematopoietic cell transplant recipients.

    abstract:PURPOSE OF REVIEW:In hematopoietic cell transplant (HCT) recipients, paramyxovirus infections are major viral respiratory tract infections that, if they progress to lower respiratory tract infections, are associated with reduced survival rates in this population. There are important knowledge gaps regarding treatment d...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000503

    authors: Batista MV,El Haddad L,Chemaly RF

    更新日期:2018-12-01 00:00:00

  • Prevention and treatment of recurrent Clostridioides difficile infection.

    abstract:PURPOSE OF REVIEW:Clostridioides difficile infection (CDI) is a significant burden on the health system, especially due to high recurrence rates. Since the beginning of the CDI epidemic in early 2000s, many strategies for combatting recurrence have been explored, with moderate success so far. This review will focus on ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000587

    authors: Shin JH,Warren CA

    更新日期:2019-10-01 00:00:00

  • New anti-hepatitis B virus drugs under development and evaluation.

    abstract:PURPOSE OF REVIEW:Although available therapies can effectively inhibit hepatitis B virus (HBV) replication in patients with active chronic hepatitis B (CHB) infection, therapeutic efficacy is limited because of potential drug resistance, and an inability to mediate viral clearance and to rectify immune impairment in CH...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000318

    authors: Pan J,Tong S,Kang L,Tang J

    更新日期:2016-12-01 00:00:00

  • Clinical aspects of visceral leishmaniasis in HIV infection.

    abstract:PURPOSE OF REVIEW:HIV infection profoundly impairs the immune mechanisms needed to control and clear Leishmania infection, and outcomes in patients with HIV-associated visceral leishmaniasis are poor. This review summarizes recent work describing the epidemiology, presentation and outcomes of HIV-associated visceral le...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32835c2198

    authors: Jarvis JN,Lockwood DN

    更新日期:2013-02-01 00:00:00

  • New antibiotics for community-acquired pneumonia.

    abstract:PURPOSE OF REVIEW:This review provides the rationale for the development of new antibiotics to treat community-acquired pneumonia (CAP). It also provides an overview of the new antibiotics targeting CAP that have recently received approval by the regulatory agencies, and those antibiotics that are in the development pi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000526

    authors: Kollef MH,Betthauser KD

    更新日期:2019-04-01 00:00:00

  • Mechanisms of chronic enteroviral persistence in tissue.

    abstract::Although the association remains controversial, enteroviruses have been implicated in the aetiology of several chronic diseases in humans. Investigations in vitro lead to better understanding of virus-cell interactions, and improve our knowledge of the molecular factors that are involved in the establishment and maint...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200106000-00002

    authors: Frisk G

    更新日期:2001-06-01 00:00:00

  • Complicated urinary tract infection.

    abstract::Urinary tract infection is the second commonest infection encountered in both the community and the hospital setting. In order to avoid complications and to minimize the unnecessary use of antibiotics, it is essential to have a useful and rapid screening test to identify urinary tract infection. The presence of nitrit...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199802000-00014

    authors: Smyth EG,O'Connell N

    更新日期:1998-02-01 00:00:00

  • Recent developments in leishmaniasis.

    abstract:PURPOSE OF REVIEW:The leishmaniases, caused by protozoan parasites of the genus Leishmania, are a significant health problem in many regions of the world. This review highlights the recent advances in the study of leishmaniasis related to parasite biology, disease pathogenesis, clinical evaluation and treatment, and pr...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200210000-00005

    authors: Melby PC

    更新日期:2002-10-01 00:00:00

  • Infection control issues after bone marrow transplantation.

    abstract::Bone marrow transplant recipients are at increased risk of a variety of infections from endogenous and exogenous sources. Various practices, including the use of prophylactic agents and a controlled environment are often employed in the name of infection control. Comparable data are lacking because of non-unified defi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200108000-00005

    authors: Kusne S,Krystofiak S

    更新日期:2001-08-01 00:00:00

  • Effects of HIV voluntary medical male circumcision programs on sexually transmitted infections.

    abstract:PURPOSE OF REVIEW:Evidence of the protective effect of voluntary medical male circumcision (VMMC) against HIV is well established. However, evidence of the protective effect of VMMC against other sexually transmitted infections (STIs) has been inconsistent or scarce across different populations and settings. This revie...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000696

    authors: Matoga M,Hosseinipour MC,Jewett S,Hoffman IF,Chasela C

    更新日期:2021-02-01 00:00:00

  • The role of multiplex molecular panels for the diagnosis of gastrointestinal infections in immunocompromised patients.

    abstract:PURPOSE OF REVIEW:An increasing number of laboratories have implemented multiplex molecular panels for the diagnosis of gastrointestinal infections. This review focuses on recent data addressing the performance of US Food and Drug Administration-cleared multiplex gastrointestinal panels and discusses the advantages and...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000276

    authors: Liesman RM,Binnicker MJ

    更新日期:2016-08-01 00:00:00

  • Recent advances in development of amphotericin B formulations for the treatment of visceral leishmaniasis.

    abstract:PURPOSE OF REVIEW:Amphotericin B (AmpB) is considered the first-line treatment for visceral leishmaniasis in areas in which resistance to antimony is prevalent. This review describes recent advances in clinically available and novel drug delivery systems of AmpB to treat visceral leishmaniasis. RECENT FINDINGS:Over th...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328359eff2

    authors: Mohamed-Ahmed AH,Brocchini S,Croft SL

    更新日期:2012-12-01 00:00:00

  • Strategies to reverse drug resistance in malaria.

    abstract:PURPOSE OF REVIEW:Despite the current success of artemisinin combination therapy, the threat of drug-resistant falciparum malaria remains severe. Reversal of resistance to old drugs remains one strategy to deal with this problem. This review highlights recent significant findings. RECENT FINDINGS:This review provides ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3282f1673a

    authors: Egan TJ,Kaschula CH

    更新日期:2007-12-01 00:00:00

  • Fractional-dose yellow fever vaccination: how much more can we do with less?

    abstract:PURPOSE OF REVIEW:Climate change, deforestation, urbanization, and increased population mobility have made the risk of large outbreaks of yellow fever more likely than ever. Yellow fever vaccine production barely meets demands. In this review, we address the causes of the recent yellow fever outbreaks, why fractional d...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000576

    authors: Visser LG

    更新日期:2019-10-01 00:00:00

  • Update on nonantibiotic therapies for acute gastroenteritis.

    abstract:PURPOSE OF REVIEW:The aim of this review is to provide an update of nonantibiotic therapies for acute gastroenteritis (AGE), focusing on antiemetics and probiotics. RECENT FINDINGS:The mainstay of therapy for nonsevere AGE remains oral rehydration therapy (ORT). Recent randomized controlled trials and metaanalyses hav...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000670

    authors: Funk A,Schnadower D,Freedman SB

    更新日期:2020-10-01 00:00:00