Abstract:
PURPOSE OF REVIEW:Hidradenitis suppurativa is a chronic or relapsing inflammatory cutaneous disorder manifested by recurrent formation of abscesses, fistulating sinus and scarring in the apocrine-gland-bearing skin. This review discusses the different aetiological theories and management opportunities. RECENT FINDINGS:Current understanding of the pathogenesis suggests that hyperkeratosis of the infundibulum, leading to follicular occlusion of the pilosebaceous unit plays a role. Bacterial infection with staphylococci, Escherichia coli and streptococcus is considered as a secondary event in the pathogenesis. Smoking and obesity are both known as risk factors and are associated with more severe disease course. Recently, more attention has been put into the understanding of the immunopathology of the skin and the results indicate that hidradenitis suppurativa may be considered as an inflammatory disease of unknown cause based on a defect in the hair follicle immunity. The treatments are most appropriately chosen on the basis of disease severity and the existence of any associated risk factors or comorbidities. There are three levels in the management of hidradenitis suppurativa: topical options, systemic options and surgical methods including laser therapy. At each level several treatment principles have shown themselves to be efficient, and may therefore be used either alone or in combination. Therapies are generally effective against microorganisms, inflammation or infundibular hyperkeratosis. Where an antimicrobial therapy is used, the drugs used often have significant additional immunomodulatory effects. SUMMARY:The recent studies give us a better insight into the pathogenesis of hidradenitis suppurativa and should translate into improved therapies.
journal_name
Curr Opin Infect Disjournal_title
Current opinion in infectious diseasesauthors
Yazdanyar S,Jemec GBdoi
10.1097/QCO.0b013e3283428d07subject
Has Abstractpub_date
2011-04-01 00:00:00pages
118-23issue
2eissn
0951-7375issn
1473-6527journal_volume
24pub_type
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32834a1bd2
更新日期:2011-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Invasive fungal infections have become the leading infectious cause of death in recipients of hematopoietic cell transplantation. Several factors have led to a renaissance in the study of invasive fungal infections. The growing incidence of both commonly encountered as well as emerging pathogens and t...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Necrotizing enterocolitis remains an enigmatic and potentially devastating condition with high morbidity and mortality. This review explores ways in which bacterial pathogens, together with gut microflora, influence the pathophysiology of necrotizing enterocolitis. Specifically, it examines the role o...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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doi:10.1097/QCO.0b013e328349ac4f
更新日期:2011-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To review available data on carbapenem use in ICU. Carbapenem is a broad spectrum well tolerated antibiotic family that keep an excellent activity to extended spectrum β-lactamases and AmpC hyperproducer and in susceptible Pseudomonas aeruginosa and Acinetobacter baumannii. It becomes a drug of choice...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
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更新日期:2001-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
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更新日期:2011-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This review presents an update on the molecular epidemic patterns of HIV-1 infection and the effects of subtype-related genetic variability on transmission, disease progression, response to antiretroviral therapy and drug-resistance pathways. RECENT FINDINGS:The molecular epidemiology of HIV-1 infect...
journal_title:Current opinion in infectious diseases
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更新日期:2006-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Several attempts have been made to combine drugs for treating visceral leishmaniasis, but only recently have effective drugs become available and combinations been tested systematically. RECENT FINDINGS:Sequential treatments with liposomal amphotericin B followed by miltefosine or paromomycin (as sho...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32833fca9d
更新日期:2010-12-01 00:00:00
abstract::The past few years have seen important developments in understanding the epidemiological and virological characteristics of rotaviruses, and rapid progress has been made in rotavirus vaccine development, but further challenges remain before a vaccine is introduced into widespread use. The licensure of the first rotavi...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/00001432-200010000-00011
更新日期:2000-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim is to describe and quantify the association between genitourinary tract infections and preterm birth. RECENT FINDINGS:Recent studies confirm the importance of identifying and treating both asymptomatic and symptomatic bacteriuria in pregnancy, which is reflected in current antenatal screening...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e328360dc31
更新日期:2013-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review addresses recent developments that relate to the pathogenesis of severe malaria and its treatment, and also highlights the increase in the global burden of malaria and provides a summary of clinical trials of malaria vaccines. RECENT FINDINGS:Malaria, one of the world's most important par...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200310000-00004
更新日期:2003-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The world's population is becoming increasing mobile. Each mobile population (e.g. immigrants, refugees, travelers) has certain characteristics that determine public health risk and infectious disease burden. Refugees present unique challenges to public health officials and infectious disease speciali...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32832f14a4
更新日期:2009-10-01 00:00:00
abstract:PURPOSE OF REVIEW:In hematopoietic cell transplant (HCT) recipients, paramyxovirus infections are major viral respiratory tract infections that, if they progress to lower respiratory tract infections, are associated with reduced survival rates in this population. There are important knowledge gaps regarding treatment d...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000503
更新日期:2018-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Clostridioides difficile infection (CDI) is a significant burden on the health system, especially due to high recurrence rates. Since the beginning of the CDI epidemic in early 2000s, many strategies for combatting recurrence have been explored, with moderate success so far. This review will focus on ...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000587
更新日期:2019-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:HIV infection profoundly impairs the immune mechanisms needed to control and clear Leishmania infection, and outcomes in patients with HIV-associated visceral leishmaniasis are poor. This review summarizes recent work describing the epidemiology, presentation and outcomes of HIV-associated visceral le...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32835c2198
更新日期:2013-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000526
更新日期:2019-04-01 00:00:00
abstract::Although the association remains controversial, enteroviruses have been implicated in the aetiology of several chronic diseases in humans. Investigations in vitro lead to better understanding of virus-cell interactions, and improve our knowledge of the molecular factors that are involved in the establishment and maint...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200106000-00002
更新日期:2001-06-01 00:00:00
abstract::Urinary tract infection is the second commonest infection encountered in both the community and the hospital setting. In order to avoid complications and to minimize the unnecessary use of antibiotics, it is essential to have a useful and rapid screening test to identify urinary tract infection. The presence of nitrit...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/00001432-199802000-00014
更新日期:1998-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200210000-00005
更新日期:2002-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2001-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
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更新日期:2021-02-01 00:00:00
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更新日期:2016-08-01 00:00:00
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更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Climate change, deforestation, urbanization, and increased population mobility have made the risk of large outbreaks of yellow fever more likely than ever. Yellow fever vaccine production barely meets demands. In this review, we address the causes of the recent yellow fever outbreaks, why fractional d...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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更新日期:2020-10-01 00:00:00