Recent advances in adherence and invasion of pathogenic Escherichia coli.

Abstract:

PURPOSE OF REVIEW:Colonization of the host epithelia by pathogenic Escherichia coli is influenced by the ability of the bacteria to interact with host surfaces. Because the initial step of an E. coli infection is to adhere, invade, and persist within host cells, some strategies used by intestinal and extraintestinal E. coli to infect host cell are presented. RECENT FINDINGS:This review highlights recent progress understanding how extraintestinal pathogenic E. coli strains express specific adhesins or invasins that allow colonization of the urinary tract or the meninges, while intestinal E. coli strains are able to colonize different regions of the intestinal tract using other specialized adhesins or invasins. Finally, evaluation of different diets and environmental conditions regulating the colonization of these pathogens is discussed. SUMMARY:Discovery of new interactions between pathogenic E. coli and the host epithelial cells unravels the need for more mechanistic studies that can provide new clues regarding how to combat these infections.

journal_name

Curr Opin Infect Dis

authors

Kalita A,Hu J,Torres AG

doi

10.1097/QCO.0000000000000092

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

459-64

issue

5

eissn

0951-7375

issn

1473-6527

journal_volume

27

pub_type

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