Methods of assessing body shape and composition in HIV-associated lipodystrophy.

abstract：PURPOSE OF REVIEW:Integrase strand transfer inhibitors (INSTIs) have become a key component of antiretroviral therapy since the approval of twice-daily raltegravir in 2007 and the more recent approval of elvitegravir in 2012. At the same time, a third compound, dolutegravir, is in late-phase clinical trials, being test...

journal_title：Current opinion in infectious diseases

authors： Quashie PK,Mesplède T,Wainberg MA

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence of the protective effect of voluntary medical male circumcision (VMMC) against HIV is well established. However, evidence of the protective effect of VMMC against other sexually transmitted infections (STIs) has been inconsistent or scarce across different populations and settings. This revie...

journal_title：Current opinion in infectious diseases

authors： Matoga M,Hosseinipour MC,Jewett S,Hoffman IF,Chasela C

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Two recent large randomized placebo-controlled clinical trials of adjunctive inhaled therapy for the treatment of ventilator-associated pneumonia failed to show a mortality effect or more rapid resolution of pneumonia symptoms. Does the failure of these studies to reach their endpoints suggest the end...

journal_title：Current opinion in infectious diseases

authors： Palmer LB

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Sepsis is an inflammatory condition associated with significant morbidity and mortality. Given the lack of specific therapies for the condition, prevention has garnered significant interest and increased importance. The article reviews the current literature regarding the use of aspirin and statins fo...

journal_title：Current opinion in infectious diseases

authors： Sanchez MA,Thomas CB,O'Neal HR

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies suggest that contemporary antibiotic dosing is unlikely to achieve best outcomes for critically ill patients because of extensive pharmacokinetic variability and altered pharmacodynamics. Dose adaptation is considered quite challenging because of unpredictable dose-exposure relationship...

journal_title：Current opinion in infectious diseases

authors： Parker SL,Sime FB,Roberts JA

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the availability of new antifungals and improved antifungal formulations, there is a continued need for the development of new drugs to treat invasive fungal infections. In high-risk populations, including heavily immunocompromised patients, those with multiple comorbidities, and patients in i...

journal_title：Current opinion in infectious diseases

authors： Wiederhold NP,Patterson TF

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The review examines the changing causes and the investigation of infectious and noninfectious diarrhoea in individuals with HIV. RECENT FINDINGS:Despite the excellent prognosis conferred by combination antiretroviral therapy, diarrhoea is still common in HIV-positive individuals and is associated wit...

journal_title：Current opinion in infectious diseases

authors： Logan C,Beadsworth MB,Beeching NJ

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Hepatitis E, a disease transmitted by hepatitis E virus, is increasingly recognized as being indigenous to affluent, temperate-zone countries. Issues pertaining to disease acquisition and hepatitis E virus infection, particularly in Western countries, are reviewed and highlighted. RECENT FINDINGS:Cli...

journal_title：Current opinion in infectious diseases

authors： Teo CG

更新日期：2006-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (InSTI) with an outstanding antiviral potency, good tolerability, good pharmacokinetic profile with a lack of major drug-drug interactions, and a barrier to resistance higher than the other compounds of the class (raltegravi...

journal_title：Current opinion in infectious diseases

authors： Blanco JL,Marcelin AG,Katlama C,Martinez E

更新日期：2018-06-01 00:00:00

abstract：:The subject of bacterial skin infection in the tropics has shown some significant advances in the past few years, although it is still relatively understudied. Of special interest is the emerging concern about the public health aspects of pyoderma, either primary or secondary to scabies, in developing countries. In ad...

journal_title：Current opinion in infectious diseases

authors： Mahé A

更新日期：2001-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Bacterial zoonoses are increasingly described in association with travel. Some bacterial zoonoses constitute important causes of post-travel illness. We focus on leptospirosis and rickettsiosis - the most common travel-associated bacterial zoonoses. RECENT FINDINGS:Leptospirosis is regarded to be the...

journal_title：Current opinion in infectious diseases

authors： Leshem E,Meltzer E,Schwartz E

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The majority of hepatitis C virus (HCV) infections in the United Kingdom and many developing countries were acquired through injecting. New clinical guidance suggests that HCV treatment should be offered to people with a transmission risk - such as people who inject drugs (PWID) - irrespective of seve...

journal_title：Current opinion in infectious diseases

authors： Hickman M,De Angelis D,Vickerman P,Hutchinson S,Martin NK

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Invasive fungal infections are an escalating problem in paediatrics. The purpose of this review is to update the recent evidence on antifungal treatment options as well as to provide an outline of best practices in treating children. RECENT FINDINGS:Candida and Aspergillus species are the leading cau...

journal_title：Current opinion in infectious diseases

authors： Katragkou A,Roilides E

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV infection profoundly impairs the immune mechanisms needed to control and clear Leishmania infection, and outcomes in patients with HIV-associated visceral leishmaniasis are poor. This review summarizes recent work describing the epidemiology, presentation and outcomes of HIV-associated visceral le...

journal_title：Current opinion in infectious diseases

authors： Jarvis JN,Lockwood DN

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Modeling of antibiotic resistance in pathogenic bacteria responsible for human disease has developed considerably over the last decade. Herein, we summarize the main published studies to illustrate the contribution of models for understanding both within-host and population-based phenomena. We then su...

journal_title：Current opinion in infectious diseases

authors： Opatowski L,Guillemot D,Boëlle PY,Temime L

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:As physicians are confronted with a diversity of adverse events and variability in response to medication among patients, this review will focus on the available evidence regarding the impact of genetic variation on drug response. Specifically, variation in drug metabolizing enzymes such as the cytoch...

journal_title：Current opinion in infectious diseases

authors： Boffito M,Winston A,Owen A

更新日期：2005-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Healthcare-associated infections (HAIs) challenge healthcare systems worldwide. As healthcare workers' hands are considered the main vector for transmission of pathogens, effective hand hygiene is the single most important action to prevent HAIs. We sought to highlight new developments and advances in...

journal_title：Current opinion in infectious diseases

authors： Stadler RN,Tschudin-Sutter S

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To explore recent developments in computerized evidence-based guidelines and decision support systems that have been designed to improve the effectiveness and efficiency of antibiotic prescribing. RECENT FINDINGS:The most frequently utilized decision support systems are electronic guidelines and prot...

journal_title：Current opinion in infectious diseases

authors： Sintchenko V,Coiera E,Gilbert GL

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To consider new treatment options for cytomegalovirus (CMV) infection, review recent trials, and anticipate their use in clinical practice, focussing on bone marrow transplantation, congenital infection, and intervention during pregnancy. RECENT FINDINGS:Three double-blind randomized placebo-controll...

journal_title：Current opinion in infectious diseases

authors： Griffiths P,Lumley S

更新日期：2014-12-01 00:00:00

abstract：:Helicobacter pylori is a bacterium that colonizes the human stomach, especially during childhood. Although it has been studied intensively during the past decade, many controversies still exist on many important issues, including the clinical relevance of virulence factors, indications for treatment, recommended proce...

journal_title：Current opinion in infectious diseases

authors： Vandenplas Y

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In contrast to patients at risk for hospital-acquired pneumonia or mechanically ventilated patients at risk for ventilator-associated pneumonia, healthcare-associated pneumonia is a relatively new clinical entity that includes a spectrum of adult patients who have close association with acute care hos...

journal_title：Current opinion in infectious diseases

authors： Craven DE

更新日期：2006-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the current success of artemisinin combination therapy, the threat of drug-resistant falciparum malaria remains severe. Reversal of resistance to old drugs remains one strategy to deal with this problem. This review highlights recent significant findings. RECENT FINDINGS:This review provides ...

journal_title：Current opinion in infectious diseases

authors： Egan TJ,Kaschula CH

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides the rationale for the development of new antibiotics to treat community-acquired pneumonia (CAP). It also provides an overview of the new antibiotics targeting CAP that have recently received approval by the regulatory agencies, and those antibiotics that are in the development pi...

journal_title：Current opinion in infectious diseases

authors： Kollef MH,Betthauser KD

更新日期：2019-04-01 00:00:00

abstract：:Influenza continues to be a major health concern and there is always the threat of a pandemic due to the emergence of a viral strain new to the human population, as exemplified by the avian influenza A/H5N1 virus which was responsible for six deaths in Hong Kong last year. Data reported in the past year, based on in-v...

journal_title：Current opinion in infectious diseases

authors： Mendel DB,Roberts NA

更新日期：1998-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Amphotericin B (AmpB) is considered the first-line treatment for visceral leishmaniasis in areas in which resistance to antimony is prevalent. This review describes recent advances in clinically available and novel drug delivery systems of AmpB to treat visceral leishmaniasis. RECENT FINDINGS:Over th...

journal_title：Current opinion in infectious diseases

authors： Mohamed-Ahmed AH,Brocchini S,Croft SL

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:18F-Fluorodeoxyglucose positron emission tomography/computed tomography is a well-established technique for diagnosis and management of a number of neoplastic conditions. However, in recent years the body of literature regarding its potential role in infectious diseases has progressively increased, wi...

journal_title：Current opinion in infectious diseases

authors： Bassetti M,Carnelutti A,Muser D,Righi E,Petrosillo N,Di Gregorio F,Werner TJ,Alavi A

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to discuss the rationale of and current evidence for prolonged beta-lactam infusion in the management of Gram-negative infections. RECENT FINDINGS:Pharmacokinetic/pharmacodynamic (PK/PD) data from various in-vitro and in-vivo experimental studies conclusively support prolong...

journal_title：Current opinion in infectious diseases

authors： Abdul-Aziz MH,Portunato F,Roberts JA

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Opportunistic infections contribute to morbidity and mortality after myeloablative allogeneic stem cell transplantation. The development of nonmyeloablative or toxicity-reduced conditioning regimens for allogeneic hematopoietic stem cell transplantation might change this picture significantly. These r...

journal_title：Current opinion in infectious diseases

authors： Junghanss C,Marr KA

更新日期：2002-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Burkholderia mallei is a facultative intracellular pathogen that causes the highly contagious and often the fatal disease, glanders. With its high rate of infectivity via aerosol and recalcitrance toward antibiotics, this pathogen is considered a potential biological threat agent. This review focuses ...

journal_title：Current opinion in infectious diseases

authors： Saikh KU,Mott TM

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Antimicrobial resistance towards conventional antibiotics is a serious problem for modern medicine and for our society. Multidrug-resistant bacteria are very difficult to treat and treatment options have begun to run out. Here, we summarize the newest studies of drug development using cationic antimic...

journal_title：Current opinion in infectious diseases

authors： Ashby M,Petkova A,Hilpert K

更新日期：2014-06-01 00:00:00