Host determinants of antiretroviral drug activity.

abstract：PURPOSE OF REVIEW:Cytomegalovirus infection is initiated when tumor necrosis factor binds to the cytomegalovirus receptors of latently infected cells, resulting in the reactivation of the virus and the production of clinical disease of two types: direct infection causing pneumonia, mononucleosis, colitis and other vira...

journal_title：Current opinion in infectious diseases

authors： Rubin RH

更新日期：2007-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Antimicrobial resistance towards conventional antibiotics is a serious problem for modern medicine and for our society. Multidrug-resistant bacteria are very difficult to treat and treatment options have begun to run out. Here, we summarize the newest studies of drug development using cationic antimic...

journal_title：Current opinion in infectious diseases

authors： Ashby M,Petkova A,Hilpert K

更新日期：2014-06-01 00:00:00

abstract：:One of the initial responses of an organism to infection by pathogenic viruses is the synthesis of antiviral cytokines such as the type I interferons (interferon-alpha/beta), interleukins, and other proinflammatory cytokines and chemokines. Interferons provide a first line of defence against virus infections by genera...

journal_title：Current opinion in infectious diseases

authors： Grandvaux N,tenOever BR,Servant MJ,Hiscott J

更新日期：2002-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to summarize important papers concerning measles disease and measles-containing vaccines published in 2004. RECENT FINDINGS:Endemic measles has been successfully controlled in the Americas and, to a lesser extent, in Europe. This has been achieved with a high uptake of t...

journal_title：Current opinion in infectious diseases

authors： Elliman D,Sengupta N

更新日期：2005-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The need for better drugs to treat patients with Chagas disease remains urgent. This review summarizes the advancements in drug development over the past 2 years. RECENT FINDINGS:Drug development efforts are almost exclusively occurring as preclinical research, although phase II studies for the antif...

journal_title：Current opinion in infectious diseases

authors： Buckner FS,Navabi N

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To consider new treatment options for cytomegalovirus (CMV) infection, review recent trials, and anticipate their use in clinical practice, focussing on bone marrow transplantation, congenital infection, and intervention during pregnancy. RECENT FINDINGS:Three double-blind randomized placebo-controll...

journal_title：Current opinion in infectious diseases

authors： Griffiths P,Lumley S

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The scale-up of direct-acting antiviral (DAA) therapy and introduction of preexposure prophylaxis (PrEP) has changed the epidemiology of sexually acquired hepatitis C virus (HCV) amongst HIV-positive and HIV-negative MSM. RECENT FINDINGS:Sexually acquired HCV continues to occur predominantly amongst ...

journal_title：Current opinion in infectious diseases

authors： Lockart I,Matthews GV,Danta M

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:In contrast to patients at risk for hospital-acquired pneumonia or mechanically ventilated patients at risk for ventilator-associated pneumonia, healthcare-associated pneumonia is a relatively new clinical entity that includes a spectrum of adult patients who have close association with acute care hos...

journal_title：Current opinion in infectious diseases

authors： Craven DE

更新日期：2006-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Strict adherence to clinical practice guidelines is recognized to improve outcomes but the inconvenient truth is that only a small subset of what is done in medicine has been tested in appropriate, well designed studies. In this article, we aim to review controversial aspects of the clinical managemen...

journal_title：Current opinion in infectious diseases

authors： Peçanha-Pietrobom PM,Colombo AL

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Clostridioides difficile infection (CDI) is a significant burden on the health system, especially due to high recurrence rates. Since the beginning of the CDI epidemic in early 2000s, many strategies for combatting recurrence have been explored, with moderate success so far. This review will focus on ...

journal_title：Current opinion in infectious diseases

authors： Shin JH,Warren CA

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses recent developments that relate to the pathogenesis of severe malaria and its treatment, and also highlights the increase in the global burden of malaria and provides a summary of clinical trials of malaria vaccines. RECENT FINDINGS:Malaria, one of the world's most important par...

journal_title：Current opinion in infectious diseases

authors： Maitland K,Bejon P,Newton CR

更新日期：2003-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Enteric fever continues to be an important infection among populations in endemic countries and among travelers to these areas. This review aims to describe recent epidemiological trends and developments in diagnosis, treatment and prevention. RECENT FINDINGS:Data indicate that the burden of enteric ...

journal_title：Current opinion in infectious diseases

authors： Meltzer E,Schwartz E

更新日期：2010-10-01 00:00:00

abstract：:Intestinal protozoal infections cause significant disease not only in the tropics but also in immunocompromised hosts and returning travellers in the developed world. Precise diagnosis of protozoal intestinal infection by microscopy can be difficult. Enzyme immunoassays for antigen detection are being used for some pr...

journal_title：Current opinion in infectious diseases

authors： Schuster H,Chiodini PL

更新日期：2001-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Preventive chemotherapy is advocated for the global control and elimination of schistosomiasis. Despite the well known short-term benefits of treating patients for schistosomiasis, the impact of mass drug administration (MDA) campaigns to control the disease in the long term remains unresolved. RECEN...

journal_title：Current opinion in infectious diseases

authors： Olveda DU,McManus DP,Ross AG

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Particularities of the fetal immune response to infection cause a heightened inflammatory state that acts synergistically with microbial insult to induce damage. Proteomics offers the opportunity for detecting fetuses at risk of sepsis and neurological injury. RECENT FINDINGS:Molecular tools (16S-rRN...

journal_title：Current opinion in infectious diseases

authors： Buhimschi CS,Bhandari V,Han YW,Dulay AT,Baumbusch MA,Madri JA,Buhimschi IA

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent developments on evaluation of 8-aminoquinoline analogs with broader efficacy and reduced toxicity, which would provide better drugs for treatment of protozoal infections. RECENT FINDINGS:The earlier efforts towards development of 8-aminoquinoline analogs have been direct...

journal_title：Current opinion in infectious diseases

authors： Tekwani BL,Walker LA

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to evaluate basic mechanisms, prevalence, risk factors, outcomes, and potential treatments of cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). RECENT FINDINGS:In this review, we present a new model to evaluate the pathophysiology of cardiac disease in patie...

journal_title：Current opinion in infectious diseases

authors： Aliberti S,Ramirez JA

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies suggest that contemporary antibiotic dosing is unlikely to achieve best outcomes for critically ill patients because of extensive pharmacokinetic variability and altered pharmacodynamics. Dose adaptation is considered quite challenging because of unpredictable dose-exposure relationship...

journal_title：Current opinion in infectious diseases

authors： Parker SL,Sime FB,Roberts JA

更新日期：2015-12-01 00:00:00

abstract：:Development of vaccines against viral haemorrhagic fevers is a public health priority. Recent advances in our knowledge of pathogenesis and of the immune responses elicited by these viruses emphasize the crucial role of the immune system in the control of infection, but also its probable involvement in pathogenesis. S...

journal_title：Current opinion in infectious diseases

authors： Baize S,Marianneau P,Georges-Courbot MC,Deubel V

更新日期：2001-10-01 00:00:00

abstract：:Tuberculosis in childhood is an important cause of mortality worldwide. The disease is difficult to diagnose and the underlying immune mechanisms are poorly understood. Advances in the application of molecular genetic tools, as illustrated by the recent completion of the genome sequence of Mycobacterium tuberculosis, ...

journal_title：Current opinion in infectious diseases

authors： Kampmann B,Young D

更新日期：1998-06-01 00:00:00

abstract：PURPOSE OF REVIEW:We aim to review the epidemiology of respiratory viral infections and the strengths and limitations of multiplex respiratory pathogen panels that are currently available along with their respective features and differences. RECENT FINDINGS:We give particular emphasis to the pathogens included on each...

journal_title：Current opinion in infectious diseases

authors： Cawcutt KA,Fey PD,Kalil AC

更新日期：2017-04-01 00:00:00

abstract：:Helicobacter pylori is a bacterium that colonizes the human stomach, especially during childhood. Although it has been studied intensively during the past decade, many controversies still exist on many important issues, including the clinical relevance of virulence factors, indications for treatment, recommended proce...

journal_title：Current opinion in infectious diseases

authors： Vandenplas Y

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides the rationale for the development of new antibiotics to treat community-acquired pneumonia (CAP). It also provides an overview of the new antibiotics targeting CAP that have recently received approval by the regulatory agencies, and those antibiotics that are in the development pi...

journal_title：Current opinion in infectious diseases

authors： Kollef MH,Betthauser KD

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Bronchiectasis is an under-appreciated cause of chronic lung disease in the USA. We highlight developments in diagnosis and treatment of this debilitating disease. RECENT FINDINGS:A possible link between gastroesophageal reflux and development of nontuberculous mycobacterial lung disease was highligh...

journal_title：Current opinion in infectious diseases

authors： Ilowite J,Spiegler P,Chawla S

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Viruses are an increasingly recognized cause of community-acquired pneumonia (CAP), but their exact role in nosocomial pneumonia is still debated. This review focuses on the role of viruses as a cause of nosocomial pneumonia. RECENT FINDINGS:Respiratory viruses may be responsible for healthcare-a...

journal_title：Current opinion in infectious diseases

authors： Luyt CE,Bréchot N,Chastre J

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Fungal infections are prevalent in very low birthweight (<1500 g) infants and are associated with significant morbidity and mortality. A better understanding of the adherence factors, molecular diagnostics and risk factors for invasive fungal infection are important in treatment and prevention. RECEN...

journal_title：Current opinion in infectious diseases

authors： Kaufman D

更新日期：2004-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Hepatitis C virus is an RNA virus that usually establishes persistent infection in its host. As an important cause of cirrhosis and hepatocellular carcinoma worldwide, hepatitis C is a growing public health concern. Despite recent advances in therapy, most people infected with the virus can expect lif...

journal_title：Current opinion in infectious diseases

authors： Darling JM,Wright TL

更新日期：2004-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the epidemiology, strategies for early detection, and clinical management of infections caused by the most commonly found multidrug-resistant (MDR) Candida spp. RECENT FINDINGS:Increasing numbers of reports describing invasive infections by MDR Candida auris and Candida glabrata has been ...

journal_title：Current opinion in infectious diseases

authors： Colombo AL,Júnior JNA,Guinea J

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Toxoplasmosis in haematopoietic cell transplant (HCT) recipients is associated with high morbidity and mortality rates. Prophylaxis following HCT is recommended for high-risk pre-HCT toxoplasma-seropositive (pre-HCTSP) recipients. However, there is no agreement or consistency among programmes on wheth...

journal_title：Current opinion in infectious diseases

authors： Gajurel K,Dhakal R,Montoya JG

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on some of the recent advances in the understanding of HIV immunopathogenesis and the diagnosis and treatment of several autoimmune conditions associated with HIV in the era of potent antiretroviral therapy. RECENT FINDINGS:Chronic immune activation with progressive immune exhaust...

journal_title：Current opinion in infectious diseases

authors： Stratton R,Slapak G,Mahungu T,Kinloch-de Loes S

更新日期：2009-02-01 00:00:00