Abstract:
PURPOSE OF REVIEW:Preventive chemotherapy is advocated for the global control and elimination of schistosomiasis. Despite the well known short-term benefits of treating patients for schistosomiasis, the impact of mass drug administration (MDA) campaigns to control the disease in the long term remains unresolved. RECENT FINDINGS:Many studies have advocated the success of MDA programs in order to attract donor funds for elimination efforts but such successes are often short-lived given the drug does not alter the life cycle of the organism or prevent reinfection. Within a matter of months to years after halting treatment, the prevalence, intensity of infection and morbidity of disease return to baseline levels. Other mitigating factors contribute to the failings of MDA campaigns namely: poverty, poor drug coverage, poor drug compliance, and, in the case of Asiatic schistosomiasis, zoonotic transmission. Genetic and innate and acquired immunologic mechanisms complicate the epidemiologic picture of schistosomiasis globally, and may contribute indirectly to MDA shortcomings. The possibility of drug resistance is an ever present concern because of the sole reliance on one drug, praziquantel. SUMMARY:Preventive chemotherapy is advocated for the global control and elimination of schistosomiasis. The short-term benefits of MDA campaigns are well documented but the long-term benefits are questionable.
journal_name
Curr Opin Infect Disjournal_title
Current opinion in infectious diseasesauthors
Olveda DU,McManus DP,Ross AGdoi
10.1097/QCO.0000000000000312subject
Has Abstractpub_date
2016-12-01 00:00:00pages
595-608issue
6eissn
0951-7375issn
1473-6527journal_volume
29pub_type
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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journal_title:Current opinion in infectious diseases
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更新日期:2007-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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更新日期:2017-04-01 00:00:00
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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journal_title:Current opinion in infectious diseases
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更新日期:2005-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
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更新日期:2011-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2006-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000415
更新日期:2018-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
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更新日期:2011-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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更新日期:2017-12-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00