Antibiotic stewardship: overcoming implementation barriers.

abstract：PURPOSE OF REVIEW:The aim of the article is to present recent epidemiological, microbiological, and clinical data for the surgical, antimicrobial, and adjunctive management of necrotizing soft-tissue infections (NSTI). RECENT FINDINGS:NSTI can be caused by a broad variety of organisms. Reports about NSTI caused by mul...

journal_title：Current opinion in infectious diseases

authors： Eckmann C,Montravers P

更新日期：2020-12-04 00:00:00

abstract：PURPOSE OF REVIEW:Necrotizing enterocolitis remains an enigmatic and potentially devastating condition with high morbidity and mortality. This review explores ways in which bacterial pathogens, together with gut microflora, influence the pathophysiology of necrotizing enterocolitis. Specifically, it examines the role o...

journal_title：Current opinion in infectious diseases

authors： Hammerman C,Kaplan M

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Schistosomiasis is a chronic and morbid disease that affects hundreds of millions of the poorest individuals in (sub)tropical regions, particularly sub-Saharan Africa. Just one drug, praziquantel (PZQ), is available. As discussed, efforts to expand mass drug administration programs may accelerate the ...

journal_title：Current opinion in infectious diseases

authors： Caffrey CR,Secor WE

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights progress made in the development of vaccines aimed at the stages of malaria parasites found in mosquitoes that block the transmission of malaria within a community. RECENT FINDINGS:Substantial progress has been made on the production and characterization of the leading candidat...

journal_title：Current opinion in infectious diseases

authors： Saul A

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent developments on evaluation of 8-aminoquinoline analogs with broader efficacy and reduced toxicity, which would provide better drugs for treatment of protozoal infections. RECENT FINDINGS:The earlier efforts towards development of 8-aminoquinoline analogs have been direct...

journal_title：Current opinion in infectious diseases

authors： Tekwani BL,Walker LA

更新日期：2006-12-01 00:00:00

abstract：:Influenza continues to be a major health concern and there is always the threat of a pandemic due to the emergence of a viral strain new to the human population, as exemplified by the avian influenza A/H5N1 virus which was responsible for six deaths in Hong Kong last year. Data reported in the past year, based on in-v...

journal_title：Current opinion in infectious diseases

authors： Mendel DB,Roberts NA

更新日期：1998-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The world's population is becoming increasing mobile. Each mobile population (e.g. immigrants, refugees, travelers) has certain characteristics that determine public health risk and infectious disease burden. Refugees present unique challenges to public health officials and infectious disease speciali...

journal_title：Current opinion in infectious diseases

authors： Stauffer WM,Weinberg M

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The success of male circumcision in reducing HIV acquisition among African heterosexuals has led to renewed interest in this biological intervention for HIV/sexually transmissible infection (STI) prevention in men who have sex with men (MSM). This review summarizes the available data on the associatio...

journal_title：Current opinion in infectious diseases

authors： Templeton DJ,Millett GA,Grulich AE

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent sequencing of the whole genome of Malassezia globosa and M. restricta forms the basis for molecular epidemiology studies and instigates investigations into their respective virulence factors. Thus, reviewing current knowledge on Malassezia molecular typing methods would reveal the pros and ...

journal_title：Current opinion in infectious diseases

authors： Gaitanis G,Bassukas ID,Velegraki A

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Infectious keratitis is a medical emergency. Improper management can lead to marked loss of vision. This review identifies recent trends in the study of infectious keratitis. RECENT FINDINGS:A multicountry outbreak of Fusarium keratitis emphasizes that contact lens wear is a major risk factor for inf...

journal_title：Current opinion in infectious diseases

authors： Thomas PA,Geraldine P

更新日期：2007-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides the rationale for the development of new antibiotics to treat community-acquired pneumonia (CAP). It also provides an overview of the new antibiotics targeting CAP that have recently received approval by the regulatory agencies, and those antibiotics that are in the development pi...

journal_title：Current opinion in infectious diseases

authors： Kollef MH,Betthauser KD

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Two recent large randomized placebo-controlled clinical trials of adjunctive inhaled therapy for the treatment of ventilator-associated pneumonia failed to show a mortality effect or more rapid resolution of pneumonia symptoms. Does the failure of these studies to reach their endpoints suggest the end...

journal_title：Current opinion in infectious diseases

authors： Palmer LB

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In contrast to patients at risk for hospital-acquired pneumonia or mechanically ventilated patients at risk for ventilator-associated pneumonia, healthcare-associated pneumonia is a relatively new clinical entity that includes a spectrum of adult patients who have close association with acute care hos...

journal_title：Current opinion in infectious diseases

authors： Craven DE

更新日期：2006-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In industrialized countries avoidance of breastfeeding is among the cornerstones of prevention of mother-to-child transmission of HIV. Breastfeeding carries risk for HIV transmission but improves survival, whereas formula feeding carries zero risk for transmission but increased risk for mortality. We ...

journal_title：Current opinion in infectious diseases

authors： Coovadia H,Kindra G

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on only the newest antifungal agents recently approved or still under development and the available data in pediatric and neonatal patients. The larger body of data in adult patients is used for comparative purposes only in an attempt to understand pediatric implications. RECENT F...

journal_title：Current opinion in infectious diseases

authors： Steinbach WJ,Benjamin DK

更新日期：2005-12-01 00:00:00

abstract：:Urinary tract infection is the second commonest infection encountered in both the community and the hospital setting. In order to avoid complications and to minimize the unnecessary use of antibiotics, it is essential to have a useful and rapid screening test to identify urinary tract infection. The presence of nitrit...

journal_title：Current opinion in infectious diseases

authors： Smyth EG,O'Connell N

更新日期：1998-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Although available therapies can effectively inhibit hepatitis B virus (HBV) replication in patients with active chronic hepatitis B (CHB) infection, therapeutic efficacy is limited because of potential drug resistance, and an inability to mediate viral clearance and to rectify immune impairment in CH...

journal_title：Current opinion in infectious diseases

authors： Pan J,Tong S,Kang L,Tang J

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Amphotericin B (AmpB) is considered the first-line treatment for visceral leishmaniasis in areas in which resistance to antimony is prevalent. This review describes recent advances in clinically available and novel drug delivery systems of AmpB to treat visceral leishmaniasis. RECENT FINDINGS:Over th...

journal_title：Current opinion in infectious diseases

authors： Mohamed-Ahmed AH,Brocchini S,Croft SL

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The immune reconstitution inflammatory syndrome (IRIS) is an important clinical complication in HIV-infected patients initiating antiretroviral therapy. This review focuses on the latest literature pertaining to the pathogenesis of IRIS. RECENT FINDINGS:The clinical manifestations of IRIS are heterog...

journal_title：Current opinion in infectious diseases

authors： Martin-Blondel G,Mars LT,Liblau RS

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Imiquimod is the first member of a new class of immune response modifiers; it was first approved in 1997 for the topical treatment of external genital and perianal warts. It is an imidazoquinoline, a novel synthetic compound which is an immune response stimulator, enhancing both the innate and acquire...

journal_title：Current opinion in infectious diseases

authors： Garland SM

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to discuss the rationale of and current evidence for prolonged beta-lactam infusion in the management of Gram-negative infections. RECENT FINDINGS:Pharmacokinetic/pharmacodynamic (PK/PD) data from various in-vitro and in-vivo experimental studies conclusively support prolong...

journal_title：Current opinion in infectious diseases

authors： Abdul-Aziz MH,Portunato F,Roberts JA

更新日期：2020-12-01 00:00:00

abstract：:Highly active antiretroviral therapy rapidly reduces virus replication in the lymphoid tissue. Production of viral RNA, however, may still be detected in the lymphoid tissue despite negative plasma viremia. Continuing virus production and latent infection in resting cells seem to be important factors for viral rebound...

journal_title：Current opinion in infectious diseases

authors： Stellbrink HJ,van Lunzen J

更新日期：2001-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Genital Chlamydia trachomatis is common among young, sexually active people. Infections are most often asymptomatic but have potential long-term consequences for female reproductive health. The link between C. trachomatis and ectopic pregnancy is mainly based on early seroepidemiological case-control ...

journal_title：Current opinion in infectious diseases

authors： Bakken IJ

更新日期：2008-02-01 00:00:00

abstract：:Therapeutic approaches in the practice of haematology/oncology are increasing in complexity. Agents such as the purine analogues and monoclonal antibodies may introduce a new spectrum of infection as a consequence of prolonged/profound lymphoid suppression. The use of high dose therapy with stem cells support is incre...

journal_title：Current opinion in infectious diseases

authors： Potter M

更新日期：1999-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Hidradenitis suppurativa is a chronic or relapsing inflammatory cutaneous disorder manifested by recurrent formation of abscesses, fistulating sinus and scarring in the apocrine-gland-bearing skin. This review discusses the different aetiological theories and management opportunities. RECENT FINDINGS...

journal_title：Current opinion in infectious diseases

authors： Yazdanyar S,Jemec GB

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The early treatment of invasive fungal infection is critical but is hampered by the non-specific nature of clinical and radiological signs and the insensitivity of current laboratory diagnostic methods. If mortality due to invasive fungal infection is to be reduced, new, preemptive therapeutic strateg...

journal_title：Current opinion in infectious diseases

authors： Jones BL,McLintock LA

更新日期：2003-12-01 00:00:00

abstract：:One of the initial responses of an organism to infection by pathogenic viruses is the synthesis of antiviral cytokines such as the type I interferons (interferon-alpha/beta), interleukins, and other proinflammatory cytokines and chemokines. Interferons provide a first line of defence against virus infections by genera...

journal_title：Current opinion in infectious diseases

authors： Grandvaux N,tenOever BR,Servant MJ,Hiscott J

更新日期：2002-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Early treatment of invasive mold infections improves the outcome. Therapy is often delayed, however, because available diagnostic tools such as culture, microscopy and conventional radiology lack sensitivity; consequently, empirical initiation of antifungal therapy has been advocated, particularly for...

journal_title：Current opinion in infectious diseases

authors： Maertens J,Deeren D,Dierickx D,Theunissen K

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To explore recent developments in computerized evidence-based guidelines and decision support systems that have been designed to improve the effectiveness and efficiency of antibiotic prescribing. RECENT FINDINGS:The most frequently utilized decision support systems are electronic guidelines and prot...

journal_title：Current opinion in infectious diseases

authors： Sintchenko V,Coiera E,Gilbert GL

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To explore how ethical considerations, improved diagnostics and data from clinical trials might see the lowering of some of the barriers blocking a cure for HIV infection over the next 5 years. RECENT FINDINGS:Despite the recent well publicized but eventually disappointing case reports, there remains...

journal_title：Current opinion in infectious diseases

authors： Thornhill J,Fidler S,Frater J

更新日期：2015-02-01 00:00:00