Advancing the HIV cure agenda: the next 5 years.


PURPOSE OF REVIEW:To explore how ethical considerations, improved diagnostics and data from clinical trials might see the lowering of some of the barriers blocking a cure for HIV infection over the next 5 years. RECENT FINDINGS:Despite the recent well publicized but eventually disappointing case reports, there remains only one successful HIV cure, the 'Berlin patient'. We will review the data suggesting that more potent agents might achieve in-vivo viral activation and explore the tantalizing phenomenon of 'posttreatment control' following treatment in primary HIV infection. We will also explore how new assays and novel interventions might move the field forward. SUMMARY:There is a need for new agents that can be safely tested to impact the viral reservoir, a more meaningful understanding of how to assay patient samples, and research into mechanisms behind how the reservoir is established and impacted by therapy. With HIV+ve individuals responding so well to antiretroviral therapy, new trials must be tested hand-in-hand with guidance from patient representatives, especially with respect to determining the acceptable risk. The road to a cure is going to be difficult, but it is vital that inevitable disappointments do not detract from the final goal, which remains worth striving for.


Curr Opin Infect Dis


Thornhill J,Fidler S,Frater J




Has Abstract


2015-02-01 00:00:00












  • Protection of healthcare workers from bloodborne pathogens.

    abstract:PURPOSE OF REVIEW:For decades, healthcare workers have been known to be at risk from acquiring a variety of bloodborne pathogen infections as a result of occupational exposure. Primary prevention of exposures, as recommended by universal precautions guidelines, remains the cornerstone of protecting healthcare workers. ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Beekmann SE,Henderson DK

    更新日期:2005-08-01 00:00:00

  • Brucellosis in low-income and middle-income countries.

    abstract:PURPOSE OF REVIEW:Human brucellosis is a neglected, underrecognized infection of widespread geographic distribution. It causes acute febrile illness and a potentially debilitating chronic infection in humans, and livestock infection has substantial socioeconomic impact. This review describes new information regarding t...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Rubach MP,Halliday JE,Cleaveland S,Crump JA

    更新日期:2013-10-01 00:00:00

  • Emerging multidrug-resistant Candida species.

    abstract:PURPOSE OF REVIEW:To describe the epidemiology, strategies for early detection, and clinical management of infections caused by the most commonly found multidrug-resistant (MDR) Candida spp. RECENT FINDINGS:Increasing numbers of reports describing invasive infections by MDR Candida auris and Candida glabrata has been ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Colombo AL,Júnior JNA,Guinea J

    更新日期:2017-12-01 00:00:00

  • Prevention and treatment of recurrent Clostridioides difficile infection.

    abstract:PURPOSE OF REVIEW:Clostridioides difficile infection (CDI) is a significant burden on the health system, especially due to high recurrence rates. Since the beginning of the CDI epidemic in early 2000s, many strategies for combatting recurrence have been explored, with moderate success so far. This review will focus on ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Shin JH,Warren CA

    更新日期:2019-10-01 00:00:00

  • Recent advances in vaccines against viral haemorrhagic fevers.

    abstract::Development of vaccines against viral haemorrhagic fevers is a public health priority. Recent advances in our knowledge of pathogenesis and of the immune responses elicited by these viruses emphasize the crucial role of the immune system in the control of infection, but also its probable involvement in pathogenesis. S...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Baize S,Marianneau P,Georges-Courbot MC,Deubel V

    更新日期:2001-10-01 00:00:00

  • Evolution of HIV integrase resistance mutations.

    abstract:PURPOSE OF REVIEW:Integrase strand transfer inhibitors (INSTIs) have become a key component of antiretroviral therapy since the approval of twice-daily raltegravir in 2007 and the more recent approval of elvitegravir in 2012. At the same time, a third compound, dolutegravir, is in late-phase clinical trials, being test...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Quashie PK,Mesplède T,Wainberg MA

    更新日期:2013-02-01 00:00:00

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    abstract:PURPOSE OF REVIEW:There is a history of inadequate treatments for cryptosporidiosis and a lack of understanding of the species that cause human disease. Against this background, we review the efficacy of antiparasitic agents, particularly nitazoxanide, which has led to increased treatment options, the potential for imm...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Smith HV,Corcoran GD

    更新日期:2004-12-01 00:00:00

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    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Ashby M,Petkova A,Hilpert K

    更新日期:2014-06-01 00:00:00

  • Fractional-dose yellow fever vaccination: how much more can we do with less?

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    pub_type: 杂志文章,评审


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    更新日期:2019-10-01 00:00:00

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    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


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    更新日期:2012-06-01 00:00:00

  • Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future.

    abstract:PURPOSE OF REVIEW:Particularities of the fetal immune response to infection cause a heightened inflammatory state that acts synergistically with microbial insult to induce damage. Proteomics offers the opportunity for detecting fetuses at risk of sepsis and neurological injury. RECENT FINDINGS:Molecular tools (16S-rRN...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Buhimschi CS,Bhandari V,Han YW,Dulay AT,Baumbusch MA,Madri JA,Buhimschi IA

    更新日期:2009-06-01 00:00:00

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    abstract:PURPOSE OF REVIEW:Antibiotic resistance continues to rise, whereas development of new agents to counter it has slowed. A heightened need exists to maintain the effectiveness of currently available agents. This review focuses on the need for better antimicrobial stewardship, expected benefits of well designed antimicrob...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Goff DA

    更新日期:2011-02-01 00:00:00

  • New anti-cancer therapies, new opportunities for infection.

    abstract::Therapeutic approaches in the practice of haematology/oncology are increasing in complexity. Agents such as the purine analogues and monoclonal antibodies may introduce a new spectrum of infection as a consequence of prolonged/profound lymphoid suppression. The use of high dose therapy with stem cells support is incre...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章


    authors: Potter M

    更新日期:1999-08-01 00:00:00

  • Effects of HIV voluntary medical male circumcision programs on sexually transmitted infections.

    abstract:PURPOSE OF REVIEW:Evidence of the protective effect of voluntary medical male circumcision (VMMC) against HIV is well established. However, evidence of the protective effect of VMMC against other sexually transmitted infections (STIs) has been inconsistent or scarce across different populations and settings. This revie...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章


    authors: Matoga M,Hosseinipour MC,Jewett S,Hoffman IF,Chasela C

    更新日期:2021-02-01 00:00:00

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    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章


    authors: Funk A,Schnadower D,Freedman SB

    更新日期:2020-10-01 00:00:00

  • Therapy for pneumococcal bacteremia: monotherapy or combination therapy?

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    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Feldman C,Anderson R

    更新日期:2009-04-01 00:00:00

  • Molecular evolution and functional divergence of Vibrio cholerae.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to synopsize and highlight the recent subtle genetic changes in cholera causing toxigenic Vibrio cholerae with special reference to their virulence, integrating and conjugative elements and toxin-antitoxin systems. It is not intended to cover issues on the whole genome se...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Das B,Pazhani GP,Sarkar A,Mukhopadhyay AK,Nair GB,Ramamurthy T

    更新日期:2016-10-01 00:00:00

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    abstract:PURPOSE OF REVIEW:Despite diagnostic and therapeutic advances, acute haematogenous osteomyelitis in children continues to cause significant morbidity and disease burden. The molecular epidemiology of causal organisms has wide geographic variation, but regardless of cause children often require several weeks of inpatien...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Weichert S,Sharland M,Clarke NM,Faust SN

    更新日期:2008-06-01 00:00:00

  • Therapy of nontuberculous mycobacterial disease.

    abstract:PURPOSE OF REVIEW:Nontuberculous mycobacterial disease, especially pulmonary disease, is increasingly encountered by clinicians. Therapy of the most common nontuberculous mycobacterial pathogen, Mycobacterium avium complex, improved with the introduction of macrolide-containing regimens, but treatment for this and most...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Griffith DE

    更新日期:2007-04-01 00:00:00

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    abstract:PURPOSE OF REVIEW:Bacterial zoonoses are increasingly described in association with travel. Some bacterial zoonoses constitute important causes of post-travel illness. We focus on leptospirosis and rickettsiosis - the most common travel-associated bacterial zoonoses. RECENT FINDINGS:Leptospirosis is regarded to be the...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Leshem E,Meltzer E,Schwartz E

    更新日期:2011-10-01 00:00:00

  • Molecular diagnosis of Pneumocystis pneumonia in immunocompromised patients.

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    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Guegan H,Robert-Gangneux F

    更新日期:2019-08-01 00:00:00

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    journal_title:Current opinion in infectious diseases

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    authors: Norris SJ,Weinstock GM

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    abstract:PURPOSE OF REVIEW:Ventilator-associated pneumonia (VAP) is the most frequent cause of death among the nosocomial infections acquired in the ICU. Routine surveillance endotracheal aspirate (ETA) cultures in patients on mechanical ventilation have been proposed to predict the cause of VAP. Our aim is to review the availa...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Luna CM,Bledel I,Raimondi A

    更新日期:2014-04-01 00:00:00

  • Complicated urinary tract infection.

    abstract::Urinary tract infection is the second commonest infection encountered in both the community and the hospital setting. In order to avoid complications and to minimize the unnecessary use of antibiotics, it is essential to have a useful and rapid screening test to identify urinary tract infection. The presence of nitrit...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章


    authors: Smyth EG,O'Connell N

    更新日期:1998-02-01 00:00:00

  • In pursuit of a human chlamydial vaccine.

    abstract::The best way to control chlamydial diseases is with an effective vaccine. Although previous studies suggest that a vaccine is an achievable goal, progress has been limited even though many vaccination strategies have been tested. A clearer understanding of the immunobiological basis of chlamydial protection and pathol...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章


    authors: Yang X,Brunham RC

    更新日期:1999-02-01 00:00:00

  • Bronchiectasis: new findings in the pathogenesis and treatment of this disease.

    abstract:PURPOSE OF REVIEW:Bronchiectasis is an under-appreciated cause of chronic lung disease in the USA. We highlight developments in diagnosis and treatment of this debilitating disease. RECENT FINDINGS:A possible link between gastroesophageal reflux and development of nontuberculous mycobacterial lung disease was highligh...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Ilowite J,Spiegler P,Chawla S

    更新日期:2008-04-01 00:00:00

  • Mycoplasma pneumoniae infections.

    abstract::Mycoplasma pneumoniae is a frequent cause of community-acquired respiratory infections in children and adults. Although the organism is felt to be the most frequent 'atypical' pathogen responsible for community-acquired pneumonia in adults, the prevalence of M. pneumoniae varies greatly from study to study, depending ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Hammerschlag MR

    更新日期:2001-04-01 00:00:00

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    abstract:PURPOSE OF REVIEW:Dengue, the most common arbovirus, is an increasingly significant cause of morbidity worldwide. After decades of research, an approved tetravalent dengue vaccine is finally available. Models constructed using recently available vaccine efficacy data allow for a data-driven discussion of the potential ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Robinson ML,Durbin AP

    更新日期:2017-10-01 00:00:00

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    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Parker SL,Sime FB,Roberts JA

    更新日期:2015-12-01 00:00:00

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    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审


    authors: Junghanss C,Marr KA

    更新日期:2002-08-01 00:00:00