Abstract:
PURPOSE OF REVIEW:Vaccination in pregnancy boosts maternal vaccine-specific antibody concentration and therefore increases transplacental transfer of antibody to optimize protection of the infant. The purpose of this review is to describe what is known about placental transfer of antibody in the context of vaccination in pregnancy, focussing on the recent literature and areas of debate, particularly about the timing of vaccination. RECENT FINDINGS:There is a debate about the timing of pertussis vaccination in pregnancy with some studies reporting that vaccination in the third trimester results in higher pertussis antigen-specific IgG concentrations in cord blood and others finding that the concentration is higher following vaccination in the second trimester. The impact of timing of vaccination on antibody avidity in cord blood has also been investigated and one study suggests that avidity may be increased following vaccination at 27-30 gestational weeks compared with later vaccination. SUMMARY:Understanding placental transfer of antibody is vital in informing maternal vaccination strategy. There has been recent research about the timing of pertussis vaccination in pregnancy that has implications for the timing of both current and future vaccines to be used in pregnancy.
journal_name
Curr Opin Infect Disjournal_title
Current opinion in infectious diseasesauthors
Calvert A,Jones CEdoi
10.1097/QCO.0000000000000372subject
Has Abstractpub_date
2017-06-01 00:00:00pages
268-273issue
3eissn
0951-7375issn
1473-6527journal_volume
30pub_type
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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更新日期:2011-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e3283509cfa
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2011-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e328360dc31
更新日期:2013-06-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2019-12-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e328354f179
更新日期:2012-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/00001432-199908000-00009
更新日期:1999-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/QCO.0000000000000622
更新日期:2020-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e328357e65c
更新日期:2012-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/QCO.0000000000000714
更新日期:2021-01-05 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/01.qco.0000216626.05821.40
更新日期:2006-04-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000499
更新日期:2018-12-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000531
更新日期:2019-04-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e328301391d
更新日期:2008-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/00001432-200008000-00003
更新日期:2000-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/00001432-200002000-00006
更新日期:2000-02-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2001-04-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2003-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2001-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2003-12-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00