Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment.

Abstract:

PURPOSE OF REVIEW:Mucormycosis is an increasingly common fungal infection with an unacceptably high mortality despite first-line antifungal therapy. Iron acquisition is a critical step in the causative organisms' pathogenetic mechanism. Therefore, abrogation of fungal iron acquisition is a promising therapeutic strategy to impact clinical outcomes for this deadly disease. RECENT FINDINGS:The increased risk of mucormycosis in patients with renal failure receiving deferoxamine iron chelation therapy is explained by the fact that deferoxamine actually acts as a siderophore for the agents of mucormycosis, supplying previously unavailable iron to the fungi. The iron liberated from deferoxamine is likely transported into the fungus by the high-affinity iron permease. In contrast, two other iron chelators, deferiprone and deferasirox, do not supply iron to the fungus and were shown to be cidal against Zygomycetes in vitro. Further, both iron chelators were shown to effectively treat mucormycosis in animal models, and one has been successfully used as salvage therapy for a patient with rhinocerebral mucormycosis. SUMMARY:Further investigation and development of iron chelators as adjunctive therapy for mucormycosis is warranted.

journal_name

Curr Opin Infect Dis

authors

Ibrahim AS,Spellberg B,Edwards J Jr

doi

10.1097/QCO.0b013e3283165fd1

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

620-5

issue

6

eissn

0951-7375

issn

1473-6527

pii

00001432-200812000-00008

journal_volume

21

pub_type

杂志文章,评审
  • Optimizing dosing of antibiotics in critically ill patients.

    abstract:PURPOSE OF REVIEW:Recent studies suggest that contemporary antibiotic dosing is unlikely to achieve best outcomes for critically ill patients because of extensive pharmacokinetic variability and altered pharmacodynamics. Dose adaptation is considered quite challenging because of unpredictable dose-exposure relationship...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000206

    authors: Parker SL,Sime FB,Roberts JA

    更新日期:2015-12-01 00:00:00

  • Cystic fibrosis.

    abstract::Cystic fibrosis is the most common lethal inherited disorder with autosomal recessive inheritance. Major progress has been made in understanding the molecular mechanisms leading to increased susceptibility to Pseudomonas aeruginosa colonization. Persistent respiratory infection with P. aeruginosa leads to progressive ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200204000-00013

    authors: Brennan AL,Geddes DM

    更新日期:2002-04-01 00:00:00

  • Dolutegravir resistance mutations: lessons from monotherapy studies.

    abstract:PURPOSE OF REVIEW:Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (InSTI) with an outstanding antiviral potency, good tolerability, good pharmacokinetic profile with a lack of major drug-drug interactions, and a barrier to resistance higher than the other compounds of the class (raltegravi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000453

    authors: Blanco JL,Marcelin AG,Katlama C,Martinez E

    更新日期:2018-06-01 00:00:00

  • Dengue vaccines: implications for dengue control.

    abstract:PURPOSE OF REVIEW:Dengue, the most common arbovirus, is an increasingly significant cause of morbidity worldwide. After decades of research, an approved tetravalent dengue vaccine is finally available. Models constructed using recently available vaccine efficacy data allow for a data-driven discussion of the potential ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000394

    authors: Robinson ML,Durbin AP

    更新日期:2017-10-01 00:00:00

  • Why have trials of inhaled antibiotics for ventilator-associated infections failed?

    abstract:PURPOSE OF REVIEW:Two recent large randomized placebo-controlled clinical trials of adjunctive inhaled therapy for the treatment of ventilator-associated pneumonia failed to show a mortality effect or more rapid resolution of pneumonia symptoms. Does the failure of these studies to reach their endpoints suggest the end...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000525

    authors: Palmer LB

    更新日期:2019-04-01 00:00:00

  • Childhood tuberculosis: advances in immunopathogenesis, treatment and prevention.

    abstract::Tuberculosis in childhood is an important cause of mortality worldwide. The disease is difficult to diagnose and the underlying immune mechanisms are poorly understood. Advances in the application of molecular genetic tools, as illustrated by the recent completion of the genome sequence of Mycobacterium tuberculosis, ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:

    authors: Kampmann B,Young D

    更新日期:1998-06-01 00:00:00

  • Update on treatment of cytomegalovirus infection in pregnancy and of the newborn with congenital cytomegalovirus.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to assess the recent studies of therapy of pregnant women and neonates, aimed at preventing the consequences of congenital cytomegalovirus (CMV) infection. RECENT FINDINGS:A recent randomized controlled trial of treatment of CMV during pregnancy with hyperimmune globulin...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000317

    authors: Rawlinson WD,Hamilton ST,van Zuylen WJ

    更新日期:2016-12-01 00:00:00

  • Prevention and treatment of recurrent Clostridioides difficile infection.

    abstract:PURPOSE OF REVIEW:Clostridioides difficile infection (CDI) is a significant burden on the health system, especially due to high recurrence rates. Since the beginning of the CDI epidemic in early 2000s, many strategies for combatting recurrence have been explored, with moderate success so far. This review will focus on ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000587

    authors: Shin JH,Warren CA

    更新日期:2019-10-01 00:00:00

  • Recent advances in development of amphotericin B formulations for the treatment of visceral leishmaniasis.

    abstract:PURPOSE OF REVIEW:Amphotericin B (AmpB) is considered the first-line treatment for visceral leishmaniasis in areas in which resistance to antimony is prevalent. This review describes recent advances in clinically available and novel drug delivery systems of AmpB to treat visceral leishmaniasis. RECENT FINDINGS:Over th...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328359eff2

    authors: Mohamed-Ahmed AH,Brocchini S,Croft SL

    更新日期:2012-12-01 00:00:00

  • Paramyxovirus infections in hematopoietic cell transplant recipients.

    abstract:PURPOSE OF REVIEW:In hematopoietic cell transplant (HCT) recipients, paramyxovirus infections are major viral respiratory tract infections that, if they progress to lower respiratory tract infections, are associated with reduced survival rates in this population. There are important knowledge gaps regarding treatment d...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000503

    authors: Batista MV,El Haddad L,Chemaly RF

    更新日期:2018-12-01 00:00:00

  • Hidradenitis suppurativa: a review of cause and treatment.

    abstract:PURPOSE OF REVIEW:Hidradenitis suppurativa is a chronic or relapsing inflammatory cutaneous disorder manifested by recurrent formation of abscesses, fistulating sinus and scarring in the apocrine-gland-bearing skin. This review discusses the different aetiological theories and management opportunities. RECENT FINDINGS...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283428d07

    authors: Yazdanyar S,Jemec GB

    更新日期:2011-04-01 00:00:00

  • Two drugs regimens for HIV.

    abstract:PURPOSE OF REVIEW:As the evidence for two-drug regimens (2DR) for HIV treatment accumulates and 2DR start to enter consensus guidelines, this review covers the history, rationale and current evidence for 2DR in first-line and switch settings. RECENT FINDINGS:Until recently, most evidence for 2DR was for boosted protea...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000615

    authors: Waters L,Church H

    更新日期:2020-02-01 00:00:00

  • New antibiotics for community-acquired pneumonia.

    abstract:PURPOSE OF REVIEW:This review provides the rationale for the development of new antibiotics to treat community-acquired pneumonia (CAP). It also provides an overview of the new antibiotics targeting CAP that have recently received approval by the regulatory agencies, and those antibiotics that are in the development pi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000526

    authors: Kollef MH,Betthauser KD

    更新日期:2019-04-01 00:00:00

  • Acute haematogenous osteomyelitis in children: is there any evidence for how long we should treat?

    abstract:PURPOSE OF REVIEW:Despite diagnostic and therapeutic advances, acute haematogenous osteomyelitis in children continues to cause significant morbidity and disease burden. The molecular epidemiology of causal organisms has wide geographic variation, but regardless of cause children often require several weeks of inpatien...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283005441

    authors: Weichert S,Sharland M,Clarke NM,Faust SN

    更新日期:2008-06-01 00:00:00

  • Treating tuberculosis in solid organ transplant recipients.

    abstract:PURPOSE OF REVIEW:To summarize recent findings in the management of active tuberculosis (TB) in solid organ transplant (SOT) recipients. RECENT FINDINGS:Mycobacterium tuberculosis causes substantial morbidity and mortality in SOT recipients. According to the literature, transplantation might not be an absolute contrai...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000102

    authors: Sun HY

    更新日期:2014-12-01 00:00:00

  • The role of viruses in nosocomial pneumonia.

    abstract:PURPOSE OF REVIEW:The frequency and impact of viruses among intensive care unit (ICU) nonimmunocompromised patients remains controversial. This review analyzes their place as causal pathogens in ventilator-associated pneumonia, as well as their effects on ICU patients' outcomes. RECENT FINDINGS:Herpesviruses, namely h...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328343b6e4

    authors: Chiche L,Forel JM,Papazian L

    更新日期:2011-04-01 00:00:00

  • In-vitro and in-vivo efficacy of influenza neuraminidase inhibitors.

    abstract::Influenza continues to be a major health concern and there is always the threat of a pandemic due to the emergence of a viral strain new to the human population, as exemplified by the avian influenza A/H5N1 virus which was responsible for six deaths in Hong Kong last year. Data reported in the past year, based on in-v...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199812000-00013

    authors: Mendel DB,Roberts NA

    更新日期:1998-12-01 00:00:00

  • Outbreaks of nontuberculous mycobacteria.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize the emerging literature on nontuberculous mycobacteria outbreaks in healthcare settings. As our ability to identify mycobacterial species develops, we are better able to recognize epidemiologic connections and better understand the prevalence and importance o...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000386

    authors: Sood G,Parrish N

    更新日期:2017-08-01 00:00:00

  • Community-acquired pneumonia in adults.

    abstract::Efforts to reduce hospitalization or the length of stay are common topics in papers published last year. Chlamydia pneumoniae is now recognized worldwide as a common pathogen in community-acquired pneumonia. A great variation in the frequency of various pathogens is found in different countries, stressing the importan...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199804000-00010

    authors: Holmberg H

    更新日期:1998-04-01 00:00:00

  • Best practice in treating infants and children with proven, probable or suspected invasive fungal infections.

    abstract:PURPOSE OF REVIEW:Invasive fungal infections are an escalating problem in paediatrics. The purpose of this review is to update the recent evidence on antifungal treatment options as well as to provide an outline of best practices in treating children. RECENT FINDINGS:Candida and Aspergillus species are the leading cau...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3283460e22

    authors: Katragkou A,Roilides E

    更新日期:2011-06-01 00:00:00

  • Current management of necrotizing soft-tissue infections.

    abstract:PURPOSE OF REVIEW:The aim of the article is to present recent epidemiological, microbiological, and clinical data for the surgical, antimicrobial, and adjunctive management of necrotizing soft-tissue infections (NSTI). RECENT FINDINGS:NSTI can be caused by a broad variety of organisms. Reports about NSTI caused by mul...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000700

    authors: Eckmann C,Montravers P

    更新日期:2020-12-04 00:00:00

  • Enteric fever: a travel medicine oriented view.

    abstract:PURPOSE OF REVIEW:Enteric fever continues to be an important infection among populations in endemic countries and among travelers to these areas. This review aims to describe recent epidemiological trends and developments in diagnosis, treatment and prevention. RECENT FINDINGS:Data indicate that the burden of enteric ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32833c7ca1

    authors: Meltzer E,Schwartz E

    更新日期:2010-10-01 00:00:00

  • Control of influenza in healthcare settings: early lessons from the 2009 pandemic.

    abstract:PURPOSE OF REVIEW:The emergence of 2009 pandemic H1N1 influenza A (pH1N1) has provided a unique challenge to influenza control in healthcare settings. We provide an overview of the early lessons from the 2009 pandemic. RECENT FINDINGS:The modes of influenza transmission and their contributions to the development of in...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32833bb804

    authors: Carlson AL,Budd AP,Perl TM

    更新日期:2010-08-01 00:00:00

  • Strategies to reverse drug resistance in malaria.

    abstract:PURPOSE OF REVIEW:Despite the current success of artemisinin combination therapy, the threat of drug-resistant falciparum malaria remains severe. Reversal of resistance to old drugs remains one strategy to deal with this problem. This review highlights recent significant findings. RECENT FINDINGS:This review provides ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3282f1673a

    authors: Egan TJ,Kaschula CH

    更新日期:2007-12-01 00:00:00

  • The role of multiplex molecular panels for the diagnosis of gastrointestinal infections in immunocompromised patients.

    abstract:PURPOSE OF REVIEW:An increasing number of laboratories have implemented multiplex molecular panels for the diagnosis of gastrointestinal infections. This review focuses on recent data addressing the performance of US Food and Drug Administration-cleared multiplex gastrointestinal panels and discusses the advantages and...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000276

    authors: Liesman RM,Binnicker MJ

    更新日期:2016-08-01 00:00:00

  • Cardiac diseases complicating community-acquired pneumonia.

    abstract:PURPOSE OF REVIEW:The aim is to evaluate basic mechanisms, prevalence, risk factors, outcomes, and potential treatments of cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). RECENT FINDINGS:In this review, we present a new model to evaluate the pathophysiology of cardiac disease in patie...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000055

    authors: Aliberti S,Ramirez JA

    更新日期:2014-06-01 00:00:00

  • Managing the risk of nosocomial transmission of prion diseases.

    abstract:PURPOSE OF REVIEW:Prion diseases such as Creutzfeldt-Jakob disease represent a unique infection control problem because prions exhibit an unusual resistance to conventional chemical and physical decontamination methods. This paper reviews the recent literature and provides recommendations for the prevention of nosocomi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200208000-00011

    authors: Weber DJ,Rutala WA

    更新日期:2002-08-01 00:00:00

  • Toxoplasma prophylaxis in haematopoietic cell transplant recipients: a review of the literature and recommendations.

    abstract:PURPOSE OF REVIEW:Toxoplasmosis in haematopoietic cell transplant (HCT) recipients is associated with high morbidity and mortality rates. Prophylaxis following HCT is recommended for high-risk pre-HCT toxoplasma-seropositive (pre-HCTSP) recipients. However, there is no agreement or consistency among programmes on wheth...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000169

    authors: Gajurel K,Dhakal R,Montoya JG

    更新日期:2015-08-01 00:00:00

  • Antifungal prophylaxis in neutropenia.

    abstract::Despite the widespread prophylactic use of antifungal agents in neutropenic patients, invasive fungal infections continue to emerge as major causes of morbidity and mortality. With the exception of fluconazole prophylaxis in allogeneic marrow transplant recipients, no firm conclusions can be drawn due to the lack of r...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199912000-00004

    authors: Maertens JA,Boogaerts MA

    更新日期:1999-12-01 00:00:00

  • Pathogenesis of the immune reconstitution inflammatory syndrome in HIV-infected patients.

    abstract:PURPOSE OF REVIEW:The immune reconstitution inflammatory syndrome (IRIS) is an important clinical complication in HIV-infected patients initiating antiretroviral therapy. This review focuses on the latest literature pertaining to the pathogenesis of IRIS. RECENT FINDINGS:The clinical manifestations of IRIS are heterog...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328352b664

    authors: Martin-Blondel G,Mars LT,Liblau RS

    更新日期:2012-06-01 00:00:00