New antifungal antibiotics.

abstract：PURPOSE OF REVIEW:To review risk-based pre-emptive treatment for adenovirus (ADV) based on quantitative PCR (qPCR) and to provide an update on clinical trials of brincidofovir (BCV) and ADV-specific cytotoxic T lymphocytes (ADV-CTLs). RECENT FINDINGS:ADV qPCR in various body compartments enables distinction of clinica...

journal_title：Current opinion in infectious diseases

authors： Lee YJ,Prockop SE,Papanicolaou GA

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:New respiratory viruses have been discovered in recent years and new molecular diagnostic assays have been developed that improve our understanding of respiratory virus infections. This article will review the changing epidemiology of these viruses after hematopoietic stem cell and solid organ transpl...

journal_title：Current opinion in infectious diseases

authors： Renaud C,Campbell AP

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Several attempts have been made to combine drugs for treating visceral leishmaniasis, but only recently have effective drugs become available and combinations been tested systematically. RECENT FINDINGS:Sequential treatments with liposomal amphotericin B followed by miltefosine or paromomycin (as sho...

journal_title：Current opinion in infectious diseases

authors： Olliaro PL

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Imiquimod is the first member of a new class of immune response modifiers; it was first approved in 1997 for the topical treatment of external genital and perianal warts. It is an imidazoquinoline, a novel synthetic compound which is an immune response stimulator, enhancing both the innate and acquire...

journal_title：Current opinion in infectious diseases

authors： Garland SM

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The immune reconstitution inflammatory syndrome (IRIS) is an important clinical complication in HIV-infected patients initiating antiretroviral therapy. This review focuses on the latest literature pertaining to the pathogenesis of IRIS. RECENT FINDINGS:The clinical manifestations of IRIS are heterog...

journal_title：Current opinion in infectious diseases

authors： Martin-Blondel G,Mars LT,Liblau RS

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Antimicrobial resistance towards conventional antibiotics is a serious problem for modern medicine and for our society. Multidrug-resistant bacteria are very difficult to treat and treatment options have begun to run out. Here, we summarize the newest studies of drug development using cationic antimic...

journal_title：Current opinion in infectious diseases

authors： Ashby M,Petkova A,Hilpert K

更新日期：2014-06-01 00:00:00

abstract：:Urinary tract infection is the second commonest infection encountered in both the community and the hospital setting. In order to avoid complications and to minimize the unnecessary use of antibiotics, it is essential to have a useful and rapid screening test to identify urinary tract infection. The presence of nitrit...

journal_title：Current opinion in infectious diseases

authors： Smyth EG,O'Connell N

更新日期：1998-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Clostridioides difficile infection (CDI) is a significant burden on the health system, especially due to high recurrence rates. Since the beginning of the CDI epidemic in early 2000s, many strategies for combatting recurrence have been explored, with moderate success so far. This review will focus on ...

journal_title：Current opinion in infectious diseases

authors： Shin JH,Warren CA

更新日期：2019-10-01 00:00:00

abstract：:Bone marrow transplant recipients are at increased risk of a variety of infections from endogenous and exogenous sources. Various practices, including the use of prophylactic agents and a controlled environment are often employed in the name of infection control. Comparable data are lacking because of non-unified defi...

journal_title：Current opinion in infectious diseases

authors： Kusne S,Krystofiak S

更新日期：2001-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent developments on evaluation of 8-aminoquinoline analogs with broader efficacy and reduced toxicity, which would provide better drugs for treatment of protozoal infections. RECENT FINDINGS:The earlier efforts towards development of 8-aminoquinoline analogs have been direct...

journal_title：Current opinion in infectious diseases

authors： Tekwani BL,Walker LA

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:An increasing number of laboratories have implemented multiplex molecular panels for the diagnosis of gastrointestinal infections. This review focuses on recent data addressing the performance of US Food and Drug Administration-cleared multiplex gastrointestinal panels and discusses the advantages and...

journal_title：Current opinion in infectious diseases

authors： Liesman RM,Binnicker MJ

更新日期：2016-08-01 00:00:00

abstract：:Otitis media is a very common reason for the prescription of antibiotics in children. Antimicrobial therapy is mostly empirical, based on the knowledge of the frequency and susceptibility patterns of causative pathogens and of the penetration and other pharmacokinetic properties of several oral antibiotics. Pharmacoec...

journal_title：Current opinion in infectious diseases

authors： Paradisi F,Corti G

更新日期：1998-12-01 00:00:00

abstract：:This review reports on recent developments in the areas of diagnosis, chemotherapy and pathology, where female genital schistosomiasis was recently identified as a common cause of morbidity in Schistosoma haematobium-endemic areas. As a profound understanding of processes underlying resistance and susceptibility to in...

journal_title：Current opinion in infectious diseases

authors： Yazdanbakhsh M,Deelder AM

更新日期：1998-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Climate change, deforestation, urbanization, and increased population mobility have made the risk of large outbreaks of yellow fever more likely than ever. Yellow fever vaccine production barely meets demands. In this review, we address the causes of the recent yellow fever outbreaks, why fractional d...

journal_title：Current opinion in infectious diseases

authors： Visser LG

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic pulmonary aspergillosis (CPA) is a relatively rare, slowly progressive pulmonary syndrome due to Aspergillus spp. that requires specific knowledge in terms of disease entity, diagnosis, management and azole resistance. This review focuses on the recent understanding of CPA entity and the emerg...

journal_title：Current opinion in infectious diseases

authors： Izumikawa K,Takazono T,Kohno S

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights progress made in the development of vaccines aimed at the stages of malaria parasites found in mosquitoes that block the transmission of malaria within a community. RECENT FINDINGS:Substantial progress has been made on the production and characterization of the leading candidat...

journal_title：Current opinion in infectious diseases

authors： Saul A

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the article is to present recent epidemiological, microbiological, and clinical data for the surgical, antimicrobial, and adjunctive management of necrotizing soft-tissue infections (NSTI). RECENT FINDINGS:NSTI can be caused by a broad variety of organisms. Reports about NSTI caused by mul...

journal_title：Current opinion in infectious diseases

authors： Eckmann C,Montravers P

更新日期：2020-12-04 00:00:00

abstract：:Gram-positive cocci account for the large majority of cases of infective endocarditis. Pathogenesis investigations of endocarditis have therefore focused on purported virulence factors in staphylococci, viridans group streptococci and enterococci. In addition to novel molecular techniques that have been adapted for us...

journal_title：Current opinion in infectious diseases

authors： Baddour LM

更新日期：1999-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Rates of carbapenem-resistant Enterobacteriaceae (CRE), especially Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negatives, have increased worldwide. Infections caused by these organisms have been associated with a high mortality, which might be due in part to the limited availability of an...

journal_title：Current opinion in infectious diseases

authors： Munoz-Price LS,Quinn JP

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Human brucellosis is a neglected, underrecognized infection of widespread geographic distribution. It causes acute febrile illness and a potentially debilitating chronic infection in humans, and livestock infection has substantial socioeconomic impact. This review describes new information regarding t...

journal_title：Current opinion in infectious diseases

authors： Rubach MP,Halliday JE,Cleaveland S,Crump JA

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Nontuberculous mycobacterial disease, especially pulmonary disease, is increasingly encountered by clinicians. Therapy of the most common nontuberculous mycobacterial pathogen, Mycobacterium avium complex, improved with the introduction of macrolide-containing regimens, but treatment for this and most...

journal_title：Current opinion in infectious diseases

authors： Griffith DE

更新日期：2007-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the currently available evidence about the use oritavancin and dalbavancin for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and for other potential indications. RECENT FINDINGS:In this review, we briefly summarize the available data on efficacy (from randomi...

journal_title：Current opinion in infectious diseases

authors： Bassetti M,Labate L,Vena A,Giacobbe DR

更新日期：2021-01-05 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to describe and quantify the association between genitourinary tract infections and preterm birth. RECENT FINDINGS:Recent studies confirm the importance of identifying and treating both asymptomatic and symptomatic bacteriuria in pregnancy, which is reflected in current antenatal screening...

journal_title：Current opinion in infectious diseases

authors： Cunnington M,Kortsalioudaki C,Heath P

更新日期：2013-06-01 00:00:00

abstract：:Influenza continues to be a major health concern and there is always the threat of a pandemic due to the emergence of a viral strain new to the human population, as exemplified by the avian influenza A/H5N1 virus which was responsible for six deaths in Hong Kong last year. Data reported in the past year, based on in-v...

journal_title：Current opinion in infectious diseases

authors： Mendel DB,Roberts NA

更新日期：1998-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the availability of new antifungals and improved antifungal formulations, there is a continued need for the development of new drugs to treat invasive fungal infections. In high-risk populations, including heavily immunocompromised patients, those with multiple comorbidities, and patients in i...

journal_title：Current opinion in infectious diseases

authors： Wiederhold NP,Patterson TF

更新日期：2015-12-01 00:00:00

abstract：:Lyme disease is the most common vector-borne infection affecting children living in temperate parts of the western hemisphere. The widespread anxiety about the long-term consequences of the illness, however, finds no support in the literature. Although the number of long-term follow-up studies is limited, the prognosi...

journal_title：Current opinion in infectious diseases

authors： Berglund J

更新日期：1999-06-01 00:00:00

abstract：PURPOSE OF REVIEW:HCV infection becomes chronic in 50-85% of cases. The treatment of chronic hepatitis C is currently based on a combination of pegylated interferon (IFN)-alpha and ribavirin. With this regimen, a failure to eradicate infection occurs in 18-24% of patients infected by genotype 2 or 3, and in 54-58% of p...

journal_title：Current opinion in infectious diseases

authors： Pawlotsky JM

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Sepsis is an inflammatory condition associated with significant morbidity and mortality. Given the lack of specific therapies for the condition, prevention has garnered significant interest and increased importance. The article reviews the current literature regarding the use of aspirin and statins fo...

journal_title：Current opinion in infectious diseases

authors： Sanchez MA,Thomas CB,O'Neal HR

更新日期：2012-06-01 00:00:00

abstract：:The past few years have seen important developments in understanding the epidemiological and virological characteristics of rotaviruses, and rapid progress has been made in rotavirus vaccine development, but further challenges remain before a vaccine is introduced into widespread use. The licensure of the first rotavi...

journal_title：Current opinion in infectious diseases

authors： Lynch M,Bresee JS,Gentsch JR,Glass RI

更新日期：2000-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In hematopoietic cell transplant (HCT) recipients, paramyxovirus infections are major viral respiratory tract infections that, if they progress to lower respiratory tract infections, are associated with reduced survival rates in this population. There are important knowledge gaps regarding treatment d...

journal_title：Current opinion in infectious diseases

authors： Batista MV,El Haddad L,Chemaly RF

更新日期：2018-12-01 00:00:00