Role or oritavancin and dalbavancin in acute bacterial skin and skin structure infections and other potential indications.

Abstract:

PURPOSE OF REVIEW:To discuss the currently available evidence about the use oritavancin and dalbavancin for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and for other potential indications. RECENT FINDINGS:In this review, we briefly summarize the available data on efficacy (from randomized controlled trials) and on effectiveness and cure rates (from observational studies) pertaining to the use of oritavancin and dalbavancin either for ABSSSI or for other indications. SUMMARY:Oritavancin and dalbavancin are valid options for outpatient therapy and early discharge in patients with ABSSSI, especially when adherence to oral therapy cannot be guaranteed or no oral choices are available. Furthermore, it is worth noting that a non-negligible portion (sometimes the majority) of oritavancin and dalbavancin use in available real-life experiences is for indications other than ABSSSI, especially for Gram-positive osteomyelitis and endocarditis. The number of studies on the use of long-acting lipoglycopeptides for these currently off-label indications is rapidly increasing and will help to further optimize the use of these peculiar antibiotics in the forthcoming future.

journal_name

Curr Opin Infect Dis

authors

Bassetti M,Labate L,Vena A,Giacobbe DR

doi

10.1097/QCO.0000000000000714

subject

Has Abstract

pub_date

2021-01-05 00:00:00

eissn

0951-7375

issn

1473-6527

pii

00001432-900000000-99066

journal_volume

Publish Ahead of Print

pub_type

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