Abstract:
PURPOSE OF REVIEW:This review focuses on recent developments on evaluation of 8-aminoquinoline analogs with broader efficacy and reduced toxicity, which would provide better drugs for treatment of protozoal infections. RECENT FINDINGS:The earlier efforts towards development of 8-aminoquinoline analogs have been directed to extensive derivatization programs. This has led to discovery of tafenoquine for prophylaxis against malaria infections and sitamaquine with utility for treatment of visceral leishmaniasis. Bulaquine, a primaquine pro-drug, has shown reduced methemoglobin toxicity and better malaria-transmission-blocking activity than primaquine. Stereoselective pharmacologic and toxicologic characteristics of chiral 8-aminoquinolines provided the lead for enantiomeric separation of an 8-aminoquinoline analog NPC1161B, with greatly reduced toxicity and potent antimalarial action against blood as well as tissue stages of the parasite. NPC1161B has also shown promising use as an antileishmanial agent. Better understanding of the mechanisms of toxicity and efficacy may help in development of 8-aminoquinoline analogs with superior therapeutic actions, reduced toxicity and broader utility. SUMMARY:Extensive derivatization approaches followed by better understanding of structure-activity relationships and biotransformation mechanisms of toxicity have provided 8-aminoquinoline analogs with better pharmacologic and reduced toxicologic profiles. The novel 8-aminoquinoline analogs may have broader utility in public health as future antiprotozoals.
journal_name
Curr Opin Infect Disjournal_title
Current opinion in infectious diseasesauthors
Tekwani BL,Walker LAdoi
10.1097/QCO.0b013e328010b848subject
Has Abstractpub_date
2006-12-01 00:00:00pages
623-31issue
6eissn
0951-7375issn
1473-6527pii
00001432-200612000-00015journal_volume
19pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Hepatitis C virus is an RNA virus that usually establishes persistent infection in its host. As an important cause of cirrhosis and hepatocellular carcinoma worldwide, hepatitis C is a growing public health concern. Despite recent advances in therapy, most people infected with the virus can expect lif...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200406000-00004
更新日期:2004-06-01 00:00:00
abstract:PURPOSE OF REVIEW:An increasing number of laboratories have implemented multiplex molecular panels for the diagnosis of gastrointestinal infections. This review focuses on recent data addressing the performance of US Food and Drug Administration-cleared multiplex gastrointestinal panels and discusses the advantages and...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000276
更新日期:2016-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Hepatitis E, a disease transmitted by hepatitis E virus, is increasingly recognized as being indigenous to affluent, temperate-zone countries. Issues pertaining to disease acquisition and hepatitis E virus infection, particularly in Western countries, are reviewed and highlighted. RECENT FINDINGS:Cli...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/01.qco.0000244052.61629.49
更新日期:2006-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Colonization of the host epithelia by pathogenic Escherichia coli is influenced by the ability of the bacteria to interact with host surfaces. Because the initial step of an E. coli infection is to adhere, invade, and persist within host cells, some strategies used by intestinal and extraintestinal E....
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000092
更新日期:2014-10-01 00:00:00
abstract::Interleukin-10 is the most potent anti-inflammatory cytokine yet identified. It has multiple actions affecting the innate immune system as well as humoral and cellular immune responses. It occupies a pivotal role in the regulation of the immune response to microbial pathogens in health and disease. Knowledge gained in...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/00001432-200006000-00004
更新日期:2000-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The early treatment of invasive fungal infection is critical but is hampered by the non-specific nature of clinical and radiological signs and the insensitivity of current laboratory diagnostic methods. If mortality due to invasive fungal infection is to be reduced, new, preemptive therapeutic strateg...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200312000-00002
更新日期:2003-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Clostridioides difficile infection (CDI) is a significant burden on the health system, especially due to high recurrence rates. Since the beginning of the CDI epidemic in early 2000s, many strategies for combatting recurrence have been explored, with moderate success so far. This review will focus on ...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000587
更新日期:2019-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Ventilator-associated pneumonia (VAP) is the most frequent cause of death among the nosocomial infections acquired in the ICU. Routine surveillance endotracheal aspirate (ETA) cultures in patients on mechanical ventilation have been proposed to predict the cause of VAP. Our aim is to review the availa...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000042
更新日期:2014-04-01 00:00:00
abstract::Helicobacter pylori is a bacterium that colonizes the human stomach, especially during childhood. Although it has been studied intensively during the past decade, many controversies still exist on many important issues, including the clinical relevance of virulence factors, indications for treatment, recommended proce...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200106000-00012
更新日期:2001-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Migrants living in high-income countries are disproportionately affected by HIV infection and frequently have characteristics associated with poor HIV clinical outcomes. HIV epidemiology among migrants is influenced by changes in migration patterns and variations in transmission risk behaviors. Here w...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000415
更新日期:2018-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to summarize recent developments in our understanding of the modifiable behavioural and biological factors contributing to the transmission of genital herpes simplex infection, and the limited data on the use of antiviral agents for reducing transmission risk in serodiscordan...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200402000-00009
更新日期:2004-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Fungal outbreaks have been reported in healthcare settings, showing that construction activities are a serious threat to immunocompromised hosts. Preventive measures to control fungal outbreaks (especially Aspergillus spp.) are considered essential during hospital construction. In this article, we upd...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/QCO.0000000000000566
更新日期:2019-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Co-infection with Plasmodium falciparum malaria and Epstein-Barr virus (EBV) are implicated in the cause of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in equatorial Africa. Although the causal association between EBV and eBL has been established, P. falciparum malaria's role i...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e328349ac4f
更新日期:2011-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The issue of whether the outcome of bacteremic pneumococcal infections is improved with the use of combination antibiotic therapy versus monotherapy is still not resolved. This review highlights recent studies that have addressed this issue. RECENT FINDINGS:Some studies have indicated benefit of comb...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e3283232a30
更新日期:2009-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim is to evaluate basic mechanisms, prevalence, risk factors, outcomes, and potential treatments of cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). RECENT FINDINGS:In this review, we present a new model to evaluate the pathophysiology of cardiac disease in patie...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000055
更新日期:2014-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Two recent large randomized placebo-controlled clinical trials of adjunctive inhaled therapy for the treatment of ventilator-associated pneumonia failed to show a mortality effect or more rapid resolution of pneumonia symptoms. Does the failure of these studies to reach their endpoints suggest the end...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000525
更新日期:2019-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Mucormycosis is an increasingly common fungal infection with an unacceptably high mortality despite first-line antifungal therapy. Iron acquisition is a critical step in the causative organisms' pathogenetic mechanism. Therefore, abrogation of fungal iron acquisition is a promising therapeutic strateg...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e3283165fd1
更新日期:2008-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The success of male circumcision in reducing HIV acquisition among African heterosexuals has led to renewed interest in this biological intervention for HIV/sexually transmissible infection (STI) prevention in men who have sex with men (MSM). This review summarizes the available data on the associatio...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e328334e54d
更新日期:2010-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent studies suggest that contemporary antibiotic dosing is unlikely to achieve best outcomes for critically ill patients because of extensive pharmacokinetic variability and altered pharmacodynamics. Dose adaptation is considered quite challenging because of unpredictable dose-exposure relationship...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000206
更新日期:2015-12-01 00:00:00
abstract::Bone marrow transplant recipients are at increased risk of a variety of infections from endogenous and exogenous sources. Various practices, including the use of prophylactic agents and a controlled environment are often employed in the name of infection control. Comparable data are lacking because of non-unified defi...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200108000-00005
更新日期:2001-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The leishmaniases, caused by protozoan parasites of the genus Leishmania, are a significant health problem in many regions of the world. This review highlights the recent advances in the study of leishmaniasis related to parasite biology, disease pathogenesis, clinical evaluation and treatment, and pr...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200210000-00005
更新日期:2002-10-01 00:00:00
abstract::The best way to control chlamydial diseases is with an effective vaccine. Although previous studies suggest that a vaccine is an achievable goal, progress has been limited even though many vaccination strategies have been tested. A clearer understanding of the immunobiological basis of chlamydial protection and pathol...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/00001432-199902000-00009
更新日期:1999-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Benzathine Penicillin G has been used to treat syphilis for over 50 years; however, the precise regimen of penicillin for treatment of syphilis in HIV-positive individuals remains a hot topic of debate. Although international guidelines recommend the same treatment for syphilis, regardless of HIV stat...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000132
更新日期:2015-02-01 00:00:00
abstract:PURPOSE OF REVIEW:We review the potential new diagnostic tools for determining the cause of pneumonia in the setting of community-acquired infection after outlining the limitation of currently available tests. RECENT FINDINGS:A number of new tools are on the horizon with the potential to overcome the problems of exist...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000148
更新日期:2015-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Preventive chemotherapy is advocated for the global control and elimination of schistosomiasis. Despite the well known short-term benefits of treating patients for schistosomiasis, the impact of mass drug administration (MDA) campaigns to control the disease in the long term remains unresolved. RECEN...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章
doi:10.1097/QCO.0000000000000312
更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (InSTI) with an outstanding antiviral potency, good tolerability, good pharmacokinetic profile with a lack of major drug-drug interactions, and a barrier to resistance higher than the other compounds of the class (raltegravi...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000453
更新日期:2018-06-01 00:00:00
abstract::Highly active antiretroviral therapy rapidly reduces virus replication in the lymphoid tissue. Production of viral RNA, however, may still be detected in the lymphoid tissue despite negative plasma viremia. Continuing virus production and latent infection in resting cells seem to be important factors for viral rebound...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200102000-00004
更新日期:2001-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite the availability of new antifungals and improved antifungal formulations, there is a continued need for the development of new drugs to treat invasive fungal infections. In high-risk populations, including heavily immunocompromised patients, those with multiple comorbidities, and patients in i...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000203
更新日期:2015-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Antimicrobial stewardship is now recognized as a formal strategy for curbing the upward trend in antibiotic resistance. Literature on antimicrobial stewardship has focused on areas of strategic importance and operational delivery. A number of barriers have been recognized in the implementation of succ...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e3283483262
更新日期:2011-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Particularities of the fetal immune response to infection cause a heightened inflammatory state that acts synergistically with microbial insult to induce damage. Proteomics offers the opportunity for detecting fetuses at risk of sepsis and neurological injury. RECENT FINDINGS:Molecular tools (16S-rRN...
journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32832a5963
更新日期:2009-06-01 00:00:00