Therapy for pneumococcal bacteremia: monotherapy or combination therapy?

abstract：PURPOSE OF REVIEW:Antimicrobial stewardship is now recognized as a formal strategy for curbing the upward trend in antibiotic resistance. Literature on antimicrobial stewardship has focused on areas of strategic importance and operational delivery. A number of barriers have been recognized in the implementation of succ...

journal_title：Current opinion in infectious diseases

authors： Bal AM,Gould IM

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The leishmaniases, caused by protozoan parasites of the genus Leishmania, are a significant health problem in many regions of the world. This review highlights the recent advances in the study of leishmaniasis related to parasite biology, disease pathogenesis, clinical evaluation and treatment, and pr...

journal_title：Current opinion in infectious diseases

authors： Melby PC

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Bacterial meningitis is a medical emergency and is associated with a high disease burden. We reviewed recent progress in the management of patients with community-acquired bacterial meningitis. RECENT FINDINGS:The worldwide burden of disease of bacterial meningitis remains high, despite the decreasin...

journal_title：Current opinion in infectious diseases

authors： Costerus JM,Brouwer MC,Bijlsma MW,van de Beek D

更新日期：2017-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The frequency and impact of viruses among intensive care unit (ICU) nonimmunocompromised patients remains controversial. This review analyzes their place as causal pathogens in ventilator-associated pneumonia, as well as their effects on ICU patients' outcomes. RECENT FINDINGS:Herpesviruses, namely h...

journal_title：Current opinion in infectious diseases

authors： Chiche L,Forel JM,Papazian L

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute gastroenteritis is one of the leading causes of morbidity and mortality in children in the developing world. With improvements in hygiene and sanitation, the burden of disease due to bacterial and parasitic infections has decreased and an increasing proportion of diarrhoea hospitalizations are a...

journal_title：Current opinion in infectious diseases

authors： Ramani S,Kang G

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent developments on evaluation of 8-aminoquinoline analogs with broader efficacy and reduced toxicity, which would provide better drugs for treatment of protozoal infections. RECENT FINDINGS:The earlier efforts towards development of 8-aminoquinoline analogs have been direct...

journal_title：Current opinion in infectious diseases

authors： Tekwani BL,Walker LA

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will focus on the epidemiology and cause of diarrheal illness in solid organ transplant and stem-cell transplant population recipients with a specific focus on the role of advanced multiplex technology in the diagnosis of diarrhea within this patient population. RECENT FINDINGS:A wide ran...

journal_title：Current opinion in infectious diseases

authors： Santoiemma PP,Ison MG,Angarone MP

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Toxoplasmosis in haematopoietic cell transplant (HCT) recipients is associated with high morbidity and mortality rates. Prophylaxis following HCT is recommended for high-risk pre-HCT toxoplasma-seropositive (pre-HCTSP) recipients. However, there is no agreement or consistency among programmes on wheth...

journal_title：Current opinion in infectious diseases

authors： Gajurel K,Dhakal R,Montoya JG

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The success of male circumcision in reducing HIV acquisition among African heterosexuals has led to renewed interest in this biological intervention for HIV/sexually transmissible infection (STI) prevention in men who have sex with men (MSM). This review summarizes the available data on the associatio...

journal_title：Current opinion in infectious diseases

authors： Templeton DJ,Millett GA,Grulich AE

更新日期：2010-02-01 00:00:00

abstract：:Mycoplasma pneumoniae is a frequent cause of community-acquired respiratory infections in children and adults. Although the organism is felt to be the most frequent 'atypical' pathogen responsible for community-acquired pneumonia in adults, the prevalence of M. pneumoniae varies greatly from study to study, depending ...

journal_title：Current opinion in infectious diseases

authors： Hammerschlag MR

更新日期：2001-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Healthcare-associated infections (HAIs) challenge healthcare systems worldwide. As healthcare workers' hands are considered the main vector for transmission of pathogens, effective hand hygiene is the single most important action to prevent HAIs. We sought to highlight new developments and advances in...

journal_title：Current opinion in infectious diseases

authors： Stadler RN,Tschudin-Sutter S

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Burkholderia mallei is a facultative intracellular pathogen that causes the highly contagious and often the fatal disease, glanders. With its high rate of infectivity via aerosol and recalcitrance toward antibiotics, this pathogen is considered a potential biological threat agent. This review focuses ...

journal_title：Current opinion in infectious diseases

authors： Saikh KU,Mott TM

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Clostridium difficile infection and Clostridium difficile-associated diarrhea (CDAD) are growing worldwide health threats. Recent studies have identified new host risk factors, diagnostic approaches and therapies of CDAD. The present review focuses on scientific papers published in the past 18 months ...

journal_title：Current opinion in infectious diseases

authors： DuPont HL,Garey K,Caeiro JP,Jiang ZD

更新日期：2008-10-01 00:00:00

abstract：:Urinary tract infection is the second commonest infection encountered in both the community and the hospital setting. In order to avoid complications and to minimize the unnecessary use of antibiotics, it is essential to have a useful and rapid screening test to identify urinary tract infection. The presence of nitrit...

journal_title：Current opinion in infectious diseases

authors： Smyth EG,O'Connell N

更新日期：1998-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Necrotizing enterocolitis remains an enigmatic and potentially devastating condition with high morbidity and mortality. This review explores ways in which bacterial pathogens, together with gut microflora, influence the pathophysiology of necrotizing enterocolitis. Specifically, it examines the role o...

journal_title：Current opinion in infectious diseases

authors： Hammerman C,Kaplan M

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:A review of recent developments in the understanding of the natural history of anal squamous carcinoma arising from areas of high-grade anal intraepithelial neoplasia. RECENT FINDINGS:Anal intraepithelial neoplasia is a consequence of chronic human papillomavirus infection in the anal canal and appea...

journal_title：Current opinion in infectious diseases

authors： Fox PA

更新日期：2006-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Cestodes infections in humans are among the most prevalent parasitosis worldwide. Although tapeworm infection is often asymptomatic, they can be associated with a range of symptoms. The landscape of cestode infections is changing with rapid diagnosis techniques and advanced molecular diagnosis aiding ...

journal_title：Current opinion in infectious diseases

authors： Webb C,Cabada MM

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies suggest that contemporary antibiotic dosing is unlikely to achieve best outcomes for critically ill patients because of extensive pharmacokinetic variability and altered pharmacodynamics. Dose adaptation is considered quite challenging because of unpredictable dose-exposure relationship...

journal_title：Current opinion in infectious diseases

authors： Parker SL,Sime FB,Roberts JA

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The immune reconstitution inflammatory syndrome (IRIS) is an important clinical complication in HIV-infected patients initiating antiretroviral therapy. This review focuses on the latest literature pertaining to the pathogenesis of IRIS. RECENT FINDINGS:The clinical manifestations of IRIS are heterog...

journal_title：Current opinion in infectious diseases

authors： Martin-Blondel G,Mars LT,Liblau RS

更新日期：2012-06-01 00:00:00

abstract：:The subject of bacterial skin infection in the tropics has shown some significant advances in the past few years, although it is still relatively understudied. Of special interest is the emerging concern about the public health aspects of pyoderma, either primary or secondary to scabies, in developing countries. In ad...

journal_title：Current opinion in infectious diseases

authors： Mahé A

更新日期：2001-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review available data on carbapenem use in ICU. Carbapenem is a broad spectrum well tolerated antibiotic family that keep an excellent activity to extended spectrum β-lactamases and AmpC hyperproducer and in susceptible Pseudomonas aeruginosa and Acinetobacter baumannii. It becomes a drug of choice...

journal_title：Current opinion in infectious diseases

authors： Patrier J,Timsit JF

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to summarize recent developments in our understanding of the modifiable behavioural and biological factors contributing to the transmission of genital herpes simplex infection, and the limited data on the use of antiviral agents for reducing transmission risk in serodiscordan...

journal_title：Current opinion in infectious diseases

authors： Patel R

更新日期：2004-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Bronchiectasis is an under-appreciated cause of chronic lung disease in the USA. We highlight developments in diagnosis and treatment of this debilitating disease. RECENT FINDINGS:A possible link between gastroesophageal reflux and development of nontuberculous mycobacterial lung disease was highligh...

journal_title：Current opinion in infectious diseases

authors： Ilowite J,Spiegler P,Chawla S

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Enteric fever continues to be an important infection among populations in endemic countries and among travelers to these areas. This review aims to describe recent epidemiological trends and developments in diagnosis, treatment and prevention. RECENT FINDINGS:Data indicate that the burden of enteric ...

journal_title：Current opinion in infectious diseases

authors： Meltzer E,Schwartz E

更新日期：2010-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to synopsize and highlight the recent subtle genetic changes in cholera causing toxigenic Vibrio cholerae with special reference to their virulence, integrating and conjugative elements and toxin-antitoxin systems. It is not intended to cover issues on the whole genome se...

journal_title：Current opinion in infectious diseases

authors： Das B,Pazhani GP,Sarkar A,Mukhopadhyay AK,Nair GB,Ramamurthy T

更新日期：2016-10-01 00:00:00

abstract：:Herpes simplex virus persists in a latent form for the life of its host, periodically reactivating and often resulting in significant psychosocial distress for the patient. Currently no cure is available. Antiviral therapy is the main treatment modality, used either orally, intravenously, or topically to prohibit furt...

journal_title：Current opinion in infectious diseases

authors： Yeung-Yue KA,Brentjens MH,Lee PC,Tyring SK

更新日期：2002-04-01 00:00:00

abstract：PURPOSE OF REVIEW:New respiratory viruses have been discovered in recent years and new molecular diagnostic assays have been developed that improve our understanding of respiratory virus infections. This article will review the changing epidemiology of these viruses after hematopoietic stem cell and solid organ transpl...

journal_title：Current opinion in infectious diseases

authors： Renaud C,Campbell AP

更新日期：2011-08-01 00:00:00

abstract：:The past few years have seen important developments in understanding the epidemiological and virological characteristics of rotaviruses, and rapid progress has been made in rotavirus vaccine development, but further challenges remain before a vaccine is introduced into widespread use. The licensure of the first rotavi...

journal_title：Current opinion in infectious diseases

authors： Lynch M,Bresee JS,Gentsch JR,Glass RI

更新日期：2000-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on some of the recent advances in the understanding of HIV immunopathogenesis and the diagnosis and treatment of several autoimmune conditions associated with HIV in the era of potent antiretroviral therapy. RECENT FINDINGS:Chronic immune activation with progressive immune exhaust...

journal_title：Current opinion in infectious diseases

authors： Stratton R,Slapak G,Mahungu T,Kinloch-de Loes S

更新日期：2009-02-01 00:00:00

abstract：:Bone marrow transplant recipients are at increased risk of a variety of infections from endogenous and exogenous sources. Various practices, including the use of prophylactic agents and a controlled environment are often employed in the name of infection control. Comparable data are lacking because of non-unified defi...

journal_title：Current opinion in infectious diseases

authors： Kusne S,Krystofiak S

更新日期：2001-08-01 00:00:00