Community-acquired bacterial meningitis.

Abstract:

PURPOSE OF REVIEW:Bacterial meningitis is a medical emergency and is associated with a high disease burden. We reviewed recent progress in the management of patients with community-acquired bacterial meningitis. RECENT FINDINGS:The worldwide burden of disease of bacterial meningitis remains high, despite the decreasing incidence following introduction of routine vaccination campaigns. Delay in diagnosis and treatment remain major concerns in the management of acute bacterial meningitis. European Society of Clinical Microbiology and Infectious Diseases guidelines strive for a door-to-antibiotic-time less than 1 h. Polymerase chain reaction (PCR) has emerged as an important diagnostic tool to identify the causative organism. Point-of-care tests using fast multiplex PCR have been developed, but additional value has not been proven. Although anecdotal observations advocate pressure-based management, a randomized controlled trial will need to be performed first to determine efficacy and safety of such an aggressive treatment approach. Adjunctive dexamethasone remains the only adjunctive therapy with proven efficacy. SUMMARY:The incidence of bacterial meningitis has been decreasing after the implementation of effective vaccines. Treatment should be administered as soon as possible and time to treatment should not exceed 1 h.

journal_name

Curr Opin Infect Dis

authors

Costerus JM,Brouwer MC,Bijlsma MW,van de Beek D

doi

10.1097/QCO.0000000000000335

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

135-141

issue

1

eissn

0951-7375

issn

1473-6527

journal_volume

30

pub_type

杂志文章,评审
  • Travel-associated zoonotic bacterial diseases.

    abstract:PURPOSE OF REVIEW:Bacterial zoonoses are increasingly described in association with travel. Some bacterial zoonoses constitute important causes of post-travel illness. We focus on leptospirosis and rickettsiosis - the most common travel-associated bacterial zoonoses. RECENT FINDINGS:Leptospirosis is regarded to be the...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32834a1bd2

    authors: Leshem E,Meltzer E,Schwartz E

    更新日期:2011-10-01 00:00:00

  • Antibiotic resistant infections due to Streptococcus pneumoniae: impact on therapeutic options and clinical outcome.

    abstract:PURPOSE OF REVIEW:Streptococcus pneumoniae is a major cause of morbidity and mortality in the pediatric population. The development of increasing resistance to multiple classes of antibiotics is making treatment of infections due to this organism much more difficult. The ultimate impact of high-level antibiotic resista...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200306000-00015

    authors: Tan TQ

    更新日期:2003-06-01 00:00:00

  • Prolonged infusion of beta-lactam antibiotics for Gram-negative infections: rationale and evidence base.

    abstract:PURPOSE OF REVIEW:The aim of this review is to discuss the rationale of and current evidence for prolonged beta-lactam infusion in the management of Gram-negative infections. RECENT FINDINGS:Pharmacokinetic/pharmacodynamic (PK/PD) data from various in-vitro and in-vivo experimental studies conclusively support prolong...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000681

    authors: Abdul-Aziz MH,Portunato F,Roberts JA

    更新日期:2020-12-01 00:00:00

  • Antifungal prophylaxis in neutropenia.

    abstract::Despite the widespread prophylactic use of antifungal agents in neutropenic patients, invasive fungal infections continue to emerge as major causes of morbidity and mortality. With the exception of fluconazole prophylaxis in allogeneic marrow transplant recipients, no firm conclusions can be drawn due to the lack of r...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199912000-00004

    authors: Maertens JA,Boogaerts MA

    更新日期:1999-12-01 00:00:00

  • Effects of HIV voluntary medical male circumcision programs on sexually transmitted infections.

    abstract:PURPOSE OF REVIEW:Evidence of the protective effect of voluntary medical male circumcision (VMMC) against HIV is well established. However, evidence of the protective effect of VMMC against other sexually transmitted infections (STIs) has been inconsistent or scarce across different populations and settings. This revie...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000696

    authors: Matoga M,Hosseinipour MC,Jewett S,Hoffman IF,Chasela C

    更新日期:2021-02-01 00:00:00

  • Two drugs regimens for HIV.

    abstract:PURPOSE OF REVIEW:As the evidence for two-drug regimens (2DR) for HIV treatment accumulates and 2DR start to enter consensus guidelines, this review covers the history, rationale and current evidence for 2DR in first-line and switch settings. RECENT FINDINGS:Until recently, most evidence for 2DR was for boosted protea...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000615

    authors: Waters L,Church H

    更新日期:2020-02-01 00:00:00

  • Respiratory pathogen panels in the hospital: good or unnecessary?

    abstract:PURPOSE OF REVIEW:We aim to review the epidemiology of respiratory viral infections and the strengths and limitations of multiplex respiratory pathogen panels that are currently available along with their respective features and differences. RECENT FINDINGS:We give particular emphasis to the pathogens included on each...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000357

    authors: Cawcutt KA,Fey PD,Kalil AC

    更新日期:2017-04-01 00:00:00

  • Advances in antimicrobial therapy of community-acquired pneumonia.

    abstract::Community-acquired pneumonia has a significant impact upon healthcare in North America and worldwide. In the U.S. it is responsible for three to four million cases yearly and 78,000 deaths. It is not a homogeneous entity and it may be caused by a number of pathogens including Streptococcus pneumoniae, the atypicals (M...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199904000-00006

    authors: Mandell LA

    更新日期:1999-04-01 00:00:00

  • Mycoplasma pneumoniae infections.

    abstract::Mycoplasma pneumoniae is a frequent cause of community-acquired respiratory infections in children and adults. Although the organism is felt to be the most frequent 'atypical' pathogen responsible for community-acquired pneumonia in adults, the prevalence of M. pneumoniae varies greatly from study to study, depending ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200104000-00012

    authors: Hammerschlag MR

    更新日期:2001-04-01 00:00:00

  • Bronchiectasis and other chronic lung diseases in adolescents living with HIV.

    abstract:PURPOSE OF REVIEW:The incidence of pulmonary infections has declined dramatically with improved access to antiretroviral therapy (ART) and cotrimoxazole prophylaxis, but chronic lung disease (CLD) is an increasingly recognized but poorly understood complication in adolescents with perinatally acquired HIV. RECENT FIND...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000325

    authors: Attia EF,Miller RF,Ferrand RA

    更新日期:2017-02-01 00:00:00

  • 8-Aminoquinolines: future role as antiprotozoal drugs.

    abstract:PURPOSE OF REVIEW:This review focuses on recent developments on evaluation of 8-aminoquinoline analogs with broader efficacy and reduced toxicity, which would provide better drugs for treatment of protozoal infections. RECENT FINDINGS:The earlier efforts towards development of 8-aminoquinoline analogs have been direct...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e328010b848

    authors: Tekwani BL,Walker LA

    更新日期:2006-12-01 00:00:00

  • Cardiac diseases complicating community-acquired pneumonia.

    abstract:PURPOSE OF REVIEW:The aim is to evaluate basic mechanisms, prevalence, risk factors, outcomes, and potential treatments of cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). RECENT FINDINGS:In this review, we present a new model to evaluate the pathophysiology of cardiac disease in patie...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000055

    authors: Aliberti S,Ramirez JA

    更新日期:2014-06-01 00:00:00

  • Risk of invasive fungal infections during hospital construction: how to minimize its impact in immunocompromised patients.

    abstract:PURPOSE OF REVIEW:Fungal outbreaks have been reported in healthcare settings, showing that construction activities are a serious threat to immunocompromised hosts. Preventive measures to control fungal outbreaks (especially Aspergillus spp.) are considered essential during hospital construction. In this article, we upd...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/QCO.0000000000000566

    authors: Alvarez-Moreno CA,Combariza JF

    更新日期:2019-08-01 00:00:00

  • What is healthcare-associated pneumonia, and how should it be treated?

    abstract:PURPOSE OF REVIEW:In contrast to patients at risk for hospital-acquired pneumonia or mechanically ventilated patients at risk for ventilator-associated pneumonia, healthcare-associated pneumonia is a relatively new clinical entity that includes a spectrum of adult patients who have close association with acute care hos...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000216626.05821.40

    authors: Craven DE

    更新日期:2006-04-01 00:00:00

  • New developments in the pathogenesis of acute exacerbations of chronic obstructive pulmonary disease.

    abstract:PURPOSE OF REVIEW:Acute exacerbations of chronic obstructive pulmonary disease were a poorly defined and understood entity. The application of better study designs and new research methodologies has shed considerable light on the pathogenesis of this common clinical syndrome. RECENT FINDINGS:Inflammation is an importa...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200404000-00008

    authors: Sethi S

    更新日期:2004-04-01 00:00:00

  • Toxoplasma prophylaxis in haematopoietic cell transplant recipients: a review of the literature and recommendations.

    abstract:PURPOSE OF REVIEW:Toxoplasmosis in haematopoietic cell transplant (HCT) recipients is associated with high morbidity and mortality rates. Prophylaxis following HCT is recommended for high-risk pre-HCT toxoplasma-seropositive (pre-HCTSP) recipients. However, there is no agreement or consistency among programmes on wheth...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000169

    authors: Gajurel K,Dhakal R,Montoya JG

    更新日期:2015-08-01 00:00:00

  • Hepatitis E indigenous to economically developed countries: to what extent a zoonosis?

    abstract:PURPOSE OF REVIEW:Hepatitis E, a disease transmitted by hepatitis E virus, is increasingly recognized as being indigenous to affluent, temperate-zone countries. Issues pertaining to disease acquisition and hepatitis E virus infection, particularly in Western countries, are reviewed and highlighted. RECENT FINDINGS:Cli...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.qco.0000244052.61629.49

    authors: Teo CG

    更新日期:2006-10-01 00:00:00

  • 18F-Fluorodeoxyglucose positron emission tomography and infectious diseases: current applications and future perspectives.

    abstract:PURPOSE OF REVIEW:18F-Fluorodeoxyglucose positron emission tomography/computed tomography is a well-established technique for diagnosis and management of a number of neoplastic conditions. However, in recent years the body of literature regarding its potential role in infectious diseases has progressively increased, wi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000354

    authors: Bassetti M,Carnelutti A,Muser D,Righi E,Petrosillo N,Di Gregorio F,Werner TJ,Alavi A

    更新日期:2017-04-01 00:00:00

  • Natural history and long-term consequences of Lyme disease in children.

    abstract::Lyme disease is the most common vector-borne infection affecting children living in temperate parts of the western hemisphere. The widespread anxiety about the long-term consequences of the illness, however, finds no support in the literature. Although the number of long-term follow-up studies is limited, the prognosi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-199906000-00018

    authors: Berglund J

    更新日期:1999-06-01 00:00:00

  • Strategies to reverse drug resistance in malaria.

    abstract:PURPOSE OF REVIEW:Despite the current success of artemisinin combination therapy, the threat of drug-resistant falciparum malaria remains severe. Reversal of resistance to old drugs remains one strategy to deal with this problem. This review highlights recent significant findings. RECENT FINDINGS:This review provides ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e3282f1673a

    authors: Egan TJ,Kaschula CH

    更新日期:2007-12-01 00:00:00

  • The changing spectrum of candidemia in oncology patients: therapeutic implications.

    abstract::Infections caused by Candida spp. are frequent and serious in oncology patients. Over the past decade, the introduction of azole antifungals as prophylactic agents, and other factors have caused a shift in the species of Candida that cause infection. During the period under review (June 1999 to June 2000), several stu...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-200012000-00006

    authors: Marr KA

    更新日期:2000-12-01 00:00:00

  • Molecular diagnosis of Pneumocystis pneumonia in immunocompromised patients.

    abstract:PURPOSE OF REVIEW:Pneumocystis pneumonia (PCP) is a frequent opportunistic infection associated with a high mortality rate. PCP is of increasing importance in non-HIV immunocompromised patients, who present with severe respiratory distress with low fungal loads. Molecular detection of Pneumocystis in broncho-alveolar l...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000559

    authors: Guegan H,Robert-Gangneux F

    更新日期:2019-08-01 00:00:00

  • The novel applications of the quantitative analysis of neutrophil cell surface FcgammaRI (CD64) to the diagnosis of infectious and inflammatory diseases.

    abstract:PURPOSE OF REVIEW:Several studies show that the number of FcgammaRI (CD64) on the surface of neutrophils increases in infections. However, in spite of increased research interest in recent years, there is no clear general view on the usability of neutrophil FcgammaRI in clinical infection diagnostics. This review tries...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32833939b0

    authors: Nuutila J

    更新日期:2010-06-01 00:00:00

  • Immune responses in hepatitis C: is virus or host the problem?

    abstract:PURPOSE OF REVIEW:Hepatitis C virus is an RNA virus that usually establishes persistent infection in its host. As an important cause of cirrhosis and hepatocellular carcinoma worldwide, hepatitis C is a growing public health concern. Despite recent advances in therapy, most people infected with the virus can expect lif...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200406000-00004

    authors: Darling JM,Wright TL

    更新日期:2004-06-01 00:00:00

  • Infection control issues after bone marrow transplantation.

    abstract::Bone marrow transplant recipients are at increased risk of a variety of infections from endogenous and exogenous sources. Various practices, including the use of prophylactic agents and a controlled environment are often employed in the name of infection control. Comparable data are lacking because of non-unified defi...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200108000-00005

    authors: Kusne S,Krystofiak S

    更新日期:2001-08-01 00:00:00

  • Head lice: is there a solution?

    abstract::Head lice is an old problem that won't go away. Infestation with the head louse Pediculus capitis is still common in school-aged children. The majority of information about this condition is based on anecdotal evidence. There is a definite need for the standardization of detection methods for diagnosis and epidemiolog...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章

    doi:10.1097/00001432-200004000-00007

    authors: Figueroa JI

    更新日期:2000-04-01 00:00:00

  • Recent developments in leishmaniasis.

    abstract:PURPOSE OF REVIEW:The leishmaniases, caused by protozoan parasites of the genus Leishmania, are a significant health problem in many regions of the world. This review highlights the recent advances in the study of leishmaniasis related to parasite biology, disease pathogenesis, clinical evaluation and treatment, and pr...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00001432-200210000-00005

    authors: Melby PC

    更新日期:2002-10-01 00:00:00

  • New antifungal antibiotics.

    abstract:PURPOSE OF REVIEW:The incidence of both invasive fungal infections and respiratory mould infections is increasing and they cause significant costs, morbidity and mortality. Non-Aspergillus moulds are increasing as cause of lung infections in specific populations and new problems of susceptibility and resistance are app...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0b013e32835ebcb7

    authors: Paiva JA,Pereira JM

    更新日期:2013-04-01 00:00:00

  • Skin and soft tissue infections after breast surgery.

    abstract:PURPOSE OF REVIEW:Breast surgery is considered a clean surgical procedure; nevertheless, infection rates are often higher than those reported after other similarly considered clean surgeries (e.g., thyroid, hernia). Acute bacterial skin and soft tissue infections, mostly surgical site infections and implant-associated ...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/QCO.0000000000000531

    authors: Corcione S,Lupia T,De Rosa FG

    更新日期:2019-04-01 00:00:00

  • Decision support systems for antibiotic prescribing.

    abstract:PURPOSE OF REVIEW:To explore recent developments in computerized evidence-based guidelines and decision support systems that have been designed to improve the effectiveness and efficiency of antibiotic prescribing. RECENT FINDINGS:The most frequently utilized decision support systems are electronic guidelines and prot...

    journal_title:Current opinion in infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1097/qco.0b013e3283118932

    authors: Sintchenko V,Coiera E,Gilbert GL

    更新日期:2008-12-01 00:00:00