Molecular diagnosis of Pneumocystis pneumonia in immunocompromised patients.

Abstract:

PURPOSE OF REVIEW:Pneumocystis pneumonia (PCP) is a frequent opportunistic infection associated with a high mortality rate. PCP is of increasing importance in non-HIV immunocompromised patients, who present with severe respiratory distress with low fungal loads. Molecular detection of Pneumocystis in broncho-alveolar lavage (BAL) has become an important diagnostic tool, but quantitative PCR (qPCR) needs standardization. RECENT FINDINGS:Despite a high negative predictive value, the positive predictive value of qPCR is moderate, as it also detects colonized patients. Attempts are made to set a cut-off value of qPCR to discriminate between PCP and colonization, or to use noninvasive samples or combined strategies to increase specificity. SUMMARY:It is easy to set a qPCR cut-off for HIV-infected patients. In non-HIV IC patients, a gain in specificity could be obtained by combining strategies, that is, qPCR on BAL and a noninvasive sample, or qPCR and serum beta-1,3-D-glucan dosage.

journal_name

Curr Opin Infect Dis

authors

Guegan H,Robert-Gangneux F

doi

10.1097/QCO.0000000000000559

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

314-321

issue

4

eissn

0951-7375

issn

1473-6527

journal_volume

32

pub_type

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