Abstract:
PURPOSE OF REVIEW:The purpose of this review is to synopsize and highlight the recent subtle genetic changes in cholera causing toxigenic Vibrio cholerae with special reference to their virulence, integrating and conjugative elements and toxin-antitoxin systems. It is not intended to cover issues on the whole genome sequence and epidemiology of cholera. RECENT FINDINGS:Analyses have been made using major published works on genetic changes associated with potential virulence, integrating and conjugative elements and toxin-antitoxin systems of toxigenic V. cholerae. During the course of evolution, V. cholerae strains show evidence of genetic selection for the expression of additional virulence, better survival in the environment, colonization ability and antimicrobial resistance. Some of the critical modifications that occurred at the molecular level include CTXϕ genome, cholera toxin B-subunit, integrating and conjugative elements and toxin-antitoxin systems. Frequent changes in the genome of V. cholerae appear to be an ongoing dynamic process that is assisting the pathogen to subtly change during or after epidemics of cholera. SUMMARY:Cholera is a reemerging public health problem. Continued basic research is important to understand the changing dynamics of bacterial virulence, survival strategies and disease pathogenesis for efficient therapeutic intervention and to abort transmission of the disease.
journal_name
Curr Opin Infect Disjournal_title
Current opinion in infectious diseasesauthors
Das B,Pazhani GP,Sarkar A,Mukhopadhyay AK,Nair GB,Ramamurthy Tdoi
10.1097/QCO.0000000000000306subject
Has Abstractpub_date
2016-10-01 00:00:00pages
520-7issue
5eissn
0951-7375issn
1473-6527journal_volume
29pub_type
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/01.qco.0000136935.13662.af
更新日期:2004-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/01.qco.0000171921.52433.50
更新日期:2005-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0b013e32834a1bd2
更新日期:2011-10-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/QCO.0000000000000525
更新日期:2019-04-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
doi:10.1097/00001432-200106000-00002
更新日期:2001-06-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Current opinion in infectious diseases
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更新日期:2011-04-01 00:00:00
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journal_title:Current opinion in infectious diseases
pub_type: 杂志文章,评审
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journal_title:Current opinion in infectious diseases
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